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Entry version 191 (17 Jun 2020)
Sequence version 4 (17 Oct 2006)
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Protein

Sterol regulatory element-binding protein cleavage-activating protein

Gene

SCAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q12770

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q12770

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sterol regulatory element-binding protein cleavage-activating protein
Short name:
SCAP
Short name:
SREBP cleavage-activating protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCAPImported
Synonyms:KIAA01991 Publication
ORF Names:PSEC0227
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000114650.18

Human Gene Nomenclature Database

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HGNCi
HGNC:30634 SCAP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601510 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12770

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18CytoplasmicBy similarityAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 279LumenalBy similarityAdd BLAST240
Transmembranei280 – 300Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini301 – 312CytoplasmicBy similarityAdd BLAST12
Transmembranei313 – 333Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini334 – 344LumenalBy similarityAdd BLAST11
Transmembranei345 – 365Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini366 – 401CytoplasmicBy similarityAdd BLAST36
Transmembranei402 – 422Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini423LumenalBy similarity1
Transmembranei424 – 444Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini445 – 518CytoplasmicBy similarityAdd BLAST74
Transmembranei519 – 539Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini540 – 709LumenalBy similarityAdd BLAST170
Transmembranei710 – 730Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini731 – 1279CytoplasmicBy similarityAdd BLAST549

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22937

Open Targets

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OpenTargetsi
ENSG00000114650

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402461

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12770 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCAP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242783

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000512081 – 1279Sterol regulatory element-binding protein cleavage-activating proteinAdd BLAST1279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki466Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi641N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei822PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1
Modified residuei1051Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP:SREBPF2 complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2.By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q12770

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q12770

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q12770

MaxQB - The MaxQuant DataBase

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MaxQBi
Q12770

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q12770

PeptideAtlas

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PeptideAtlasi
Q12770

PRoteomics IDEntifications database

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PRIDEi
Q12770

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58915 [Q12770-1]
58916 [Q12770-2]
58917 [Q12770-3]
58918 [Q12770-4]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q12770-2 [Q12770-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q12770

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q12770

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By androgen-bound AR and glucocorticoid-bound NR3C1 in a prostate cancer cell line (LNCaP).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114650 Expressed in adrenal tissue and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q12770 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q12770 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000114650 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Membrane region forms a homotetramer.

Forms a stable complex with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain.

Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations.

Interacts with the SEC23/SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop. Binds cholesterol through its SSC domain (By similarity).

Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing.

Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116596, 76 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q12770

Protein interaction database and analysis system

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IntActi
Q12770, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265565

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12770 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini284 – 442SSDPROSITE-ProRule annotationAdd BLAST159
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati771 – 811WD 1Add BLAST41
Repeati952 – 1002WD 2Add BLAST51
Repeati1005 – 1042WD 3Add BLAST38
Repeati1077 – 1114WD 4Add BLAST38
Repeati1117 – 1155WD 5Add BLAST39
Repeati1158 – 1195WD 6Add BLAST38
Repeati1197 – 1235WD 7Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni447 – 452ER export signalBy similarity6
Regioni731 – 1279Interaction with SREBF2By similarityAdd BLAST549

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi722 – 729Poly-Leu8
Compositional biasi747 – 750Poly-Arg4
Compositional biasi861 – 864Poly-Pro4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat SCAP family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1933 Eukaryota
ENOG410XR54 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_006510_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q12770

Identification of Orthologs from Complete Genome Data

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OMAi
PIVADKC

Database of Orthologous Groups

More...
OrthoDBi
523786at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q12770

TreeFam database of animal gene trees

More...
TreeFami
TF315236

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030225 SCAP
IPR000731 SSD
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46378 PTHR46378, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12349 Sterol-sensing, 1 hit
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12770-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLTERLREK ISRAFYNHGL LCASYPIPII LFTGFCILAC CYPLLKLPLP
60 70 80 90 100
GTGPVEFTTP VKDYSPPPVD SDRKQGEPTE QPEWYVGAPV AYVQQIFVKS
110 120 130 140 150
SVFPWHKNLL AVDVFRSPLS RAFQLVEEIR NHVLRDSSGI RSLEELCLQV
160 170 180 190 200
TDLLPGLRKL RNLLPEHGCL LLSPGNFWQN DWERFHADPD IIGTIHQHEP
210 220 230 240 250
KTLQTSATLK DLLFGVPGKY SGVSLYTRKR MVSYTITLVF QHYHAKFLGS
260 270 280 290 300
LRARLMLLHP SPNCSLRAES LVHVHFKEEI GVAELIPLVT TYIILFAYIY
310 320 330 340 350
FSTRKIDMVK SKWGLALAAV VTVLSSLLMS VGLCTLFGLT PTLNGGEIFP
360 370 380 390 400
YLVVVIGLEN VLVLTKSVVS TPVDLEVKLR IAQGLSSESW SIMKNMATEL
410 420 430 440 450
GIILIGYFTL VPAIQEFCLF AVVGLVSDFF LQMLFFTTVL SIDIRRMELA
460 470 480 490 500
DLNKRLPPEA CLPSAKPVGQ PTRYERQLAV RPSTPHTITL QPSSFRNLRL
510 520 530 540 550
PKRLRVVYFL ARTRLAQRLI MAGTVVWIGI LVYTDPAGLR NYLAAQVTEQ
560 570 580 590 600
SPLGEGALAP MPVPSGMLPP SHPDPAFSIF PPDAPKLPEN QTSPGESPER
610 620 630 640 650
GGPAEVVHDS PVPEVTWGPE DEELWRKLSF RHWPTLFSYY NITLAKRYIS
660 670 680 690 700
LLPVIPVTLR LNPREALEGR HPQDGRSAWP PPGPIPAGHW EAGPKGPGGV
710 720 730 740 750
QAHGDVTLYK VAALGLATGI VLVLLLLCLY RVLCPRNYGQ LGGGPGRRRR
760 770 780 790 800
GELPCDDYGY APPETEIVPL VLRGHLMDIE CLASDGMLLV SCCLAGHVCV
810 820 830 840 850
WDAQTGDCLT RIPRPGRQRR DSGVGSGLEA QESWERLSDG GKAGPEEPGD
860 870 880 890 900
SPPLRHRPRG PPPPSLFGDQ PDLTCLIDTN FSAQPRSSQP TQPEPRHRAV
910 920 930 940 950
CGRSRDSPGY DFSCLVQRVY QEEGLAAVCT PALRPPSPGP VLSQAPEDEG
960 970 980 990 1000
GSPEKGSPSL AWAPSAEGSI WSLELQGNLI VVGRSSGRLE VWDAIEGVLC
1010 1020 1030 1040 1050
CSSEEVSSGI TALVFLDKRI VAARLNGSLD FFSLETHTAL SPLQFRGTPG
1060 1070 1080 1090 1100
RGSSPASPVY SSSDTVACHL THTVPCAHQK PITALKAAAG RLVTGSQDHT
1110 1120 1130 1140 1150
LRVFRLEDSC CLFTLQGHSG AITTVYIDQT MVLASGGQDG AICLWDVLTG
1160 1170 1180 1190 1200
SRVSHVFAHR GDVTSLTCTT SCVISSGLDD LISIWDRSTG IKFYSIQQDL
1210 1220 1230 1240 1250
GCGASLGVIS DNLLVTGGQG CVSFWDLNYG DLLQTVYLGK NSEAQPARQI
1260 1270
LVLDNAAIVC NFGSELSLVY VPSVLEKLD
Length:1,279
Mass (Da):139,729
Last modified:October 17, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CD73543B7D2ACB4
GO
Isoform 2 (identifier: Q12770-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-401: Missing.
     817-817: Missing.

Show »
Length:905
Mass (Da):97,903
Checksum:i7998FC1DB49E4CDC
GO
Isoform 3 (identifier: Q12770-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     476-983: Missing.

Show »
Length:771
Mass (Da):84,773
Checksum:iDE4C276926DBA281
GO
Isoform 4 (identifier: Q12770-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.
     817-817: Missing.

Show »
Length:886
Mass (Da):95,616
Checksum:i5ED9E0586FA01C37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTG6A0A0A0MTG6_HUMAN
Sterol regulatory element-binding p...
SCAP
905Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W921F8W921_HUMAN
Sterol regulatory element-binding p...
SCAP
121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9W7F8W9W7_HUMAN
Sterol regulatory element-binding p...
SCAP
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDP3F8WDP3_HUMAN
Sterol regulatory element-binding p...
SCAP
85Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEH8F8WEH8_HUMAN
Sterol regulatory element-binding p...
SCAP
352Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ35C9JQ35_HUMAN
Sterol regulatory element-binding p...
SCAP
136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA39D6RA39_HUMAN
Sterol regulatory element-binding p...
SCAP
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFY0C9JFY0_HUMAN
Sterol regulatory element-binding p...
SCAP
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA12111 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11673 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350P → G in BAC11673 (PubMed:16303743).Curated1
Sequence conflicti427S → T in BAC11673 (PubMed:16303743).Curated1
Sequence conflicti617W → R in BAB55088 (PubMed:14702039).Curated1
Sequence conflicti753L → Q in BAB55088 (PubMed:14702039).Curated1
Sequence conflicti941V → A in BAB55088 (PubMed:14702039).Curated1
Sequence conflicti994A → S in BAC11673 (PubMed:16303743).Curated1
Sequence conflicti1019R → G in BAC11673 (PubMed:16303743).Curated1
Sequence conflicti1035E → G in BAB55088 (PubMed:14702039).Curated1
Sequence conflicti1080K → E in BAB55088 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012203798V → I1 PublicationCorresponds to variant dbSNP:rs12487736Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0211051 – 392Missing in isoform 4. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_00745129 – 401Missing in isoform 2. 1 PublicationAdd BLAST373
Alternative sequenceiVSP_007452476 – 983Missing in isoform 3. 1 PublicationAdd BLAST508
Alternative sequenceiVSP_021106817Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D83782 mRNA Translation: BAA12111.2 Different initiation.
AK027402 mRNA Translation: BAB55088.1
BC020987 mRNA Translation: AAH20987.1
AK075528 mRNA Translation: BAC11673.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2755.2 [Q12770-1]

NCBI Reference Sequences

More...
RefSeqi
NP_036367.2, NM_012235.3 [Q12770-1]
XP_011531803.1, XM_011533501.1 [Q12770-1]
XP_016861407.1, XM_017005918.1 [Q12770-1]
XP_016861410.1, XM_017005921.1 [Q12770-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265565; ENSP00000265565; ENSG00000114650 [Q12770-1]
ENST00000648151; ENSP00000497087; ENSG00000114650 [Q12770-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22937

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22937

UCSC genome browser

More...
UCSCi
uc003crh.2 human [Q12770-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83782 mRNA Translation: BAA12111.2 Different initiation.
AK027402 mRNA Translation: BAB55088.1
BC020987 mRNA Translation: AAH20987.1
AK075528 mRNA Translation: BAC11673.1 Different initiation.
CCDSiCCDS2755.2 [Q12770-1]
RefSeqiNP_036367.2, NM_012235.3 [Q12770-1]
XP_011531803.1, XM_011533501.1 [Q12770-1]
XP_016861407.1, XM_017005918.1 [Q12770-1]
XP_016861410.1, XM_017005921.1 [Q12770-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116596, 76 interactors
CORUMiQ12770
IntActiQ12770, 9 interactors
STRINGi9606.ENSP00000265565

PTM databases

iPTMnetiQ12770
PhosphoSitePlusiQ12770

Polymorphism and mutation databases

BioMutaiSCAP
DMDMi116242783

Proteomic databases

EPDiQ12770
jPOSTiQ12770
MassIVEiQ12770
MaxQBiQ12770
PaxDbiQ12770
PeptideAtlasiQ12770
PRIDEiQ12770
ProteomicsDBi58915 [Q12770-1]
58916 [Q12770-2]
58917 [Q12770-3]
58918 [Q12770-4]
TopDownProteomicsiQ12770-2 [Q12770-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1330 219 antibodies

Genome annotation databases

EnsembliENST00000265565; ENSP00000265565; ENSG00000114650 [Q12770-1]
ENST00000648151; ENSP00000497087; ENSG00000114650 [Q12770-1]
GeneIDi22937
KEGGihsa:22937
UCSCiuc003crh.2 human [Q12770-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22937
DisGeNETi22937
EuPathDBiHostDB:ENSG00000114650.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SCAP
HGNCiHGNC:30634 SCAP
HPAiENSG00000114650 Low tissue specificity
MIMi601510 gene
neXtProtiNX_Q12770
OpenTargetsiENSG00000114650
PharmGKBiPA162402461

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1933 Eukaryota
ENOG410XR54 LUCA
GeneTreeiENSGT00940000158130
HOGENOMiCLU_006510_0_0_1
InParanoidiQ12770
OMAiPIVADKC
OrthoDBi523786at2759
PhylomeDBiQ12770
TreeFamiTF315236

Enzyme and pathway databases

ReactomeiR-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
SignaLinkiQ12770
SIGNORiQ12770

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22937 503 hits in 795 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SCAP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SREBP_cleavage_activating_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22937
PharosiQ12770 Tbio

Protein Ontology

More...
PROi
PR:Q12770
RNActiQ12770 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114650 Expressed in adrenal tissue and 225 other tissues
ExpressionAtlasiQ12770 baseline and differential
GenevisibleiQ12770 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR030225 SCAP
IPR000731 SSD
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR46378 PTHR46378, 1 hit
PfamiView protein in Pfam
PF12349 Sterol-sensing, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12770
Secondary accession number(s): Q8N2E0, Q8WUA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 17, 2006
Last modified: June 17, 2020
This is version 191 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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