ID   TMM94_HUMAN             Reviewed;        1356 AA.
AC   Q12767; O75536; Q86XF1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   15-FEB-2017, entry version 119.
DE   RecName: Full=Transmembrane protein 94 {ECO:0000312|HGNC:HGNC:28983};
GN   Name=TMEM94 {ECO:0000312|HGNC:HGNC:28983}; Synonyms=KIAA0195;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Bone marrow;
RX   PubMed=8724849; DOI=10.1093/dnares/3.1.17;
RA   Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. V.
RT   The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by
RT   analysis of cDNA clones from human cell line KG-1.";
RL   DNA Res. 3:17-24(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1155-1356 (ISOFORM 2).
RC   TISSUE=Brain;
RA   Andersson B., Wentland M.A., Ricafrente J.Y., Liu W., Gibbs R.A.;
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221 AND SER-225, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA   Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA   Greff Z., Keri G., Stemmann O., Mann M.;
RT   "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT   the kinome across the cell cycle.";
RL   Mol. Cell 31:438-448(2008).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA   Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA   Mann M., Daub H.;
RT   "Large-scale proteomics analysis of the human kinome.";
RL   Mol. Cell. Proteomics 8:1751-1764(2009).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445; SER-454 AND
RP   SER-798, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP   ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225; SER-444; SER-518
RP   AND SER-941, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP   ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q12767-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q12767-2; Sequence=VSP_011043;
CC         Note=No experimental confirmation available.;
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC       {ECO:0000269|PubMed:8724849}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA12108.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D83779; BAA12108.2; ALT_INIT; mRNA.
DR   EMBL; BC045540; AAH45540.1; -; mRNA.
DR   EMBL; AF070545; AAC28636.1; -; mRNA.
DR   CCDS; CCDS32732.1; -. [Q12767-1]
DR   RefSeq; NP_001308077.1; NM_001321148.1.
DR   RefSeq; NP_001308078.1; NM_001321149.1.
DR   RefSeq; NP_055553.3; NM_014738.5. [Q12767-1]
DR   UniGene; Hs.514474; -.
DR   ProteinModelPortal; Q12767; -.
DR   BioGrid; 115117; 7.
DR   IntAct; Q12767; 1.
DR   STRING; 9606.ENSP00000313885; -.
DR   iPTMnet; Q12767; -.
DR   PhosphoSitePlus; Q12767; -.
DR   BioMuta; KIAA0195; -.
DR   DMDM; 2495718; -.
DR   MaxQB; Q12767; -.
DR   PaxDb; Q12767; -.
DR   PeptideAtlas; Q12767; -.
DR   PRIDE; Q12767; -.
DR   Ensembl; ENST00000314256; ENSP00000313885; ENSG00000177728. [Q12767-1]
DR   GeneID; 9772; -.
DR   KEGG; hsa:9772; -.
DR   UCSC; uc002jnz.5; human. [Q12767-1]
DR   CTD; 9772; -.
DR   DisGeNET; 9772; -.
DR   GeneCards; MIR6785; -.
DR   GeneCards; TMEM94; -.
DR   HGNC; HGNC:28983; TMEM94.
DR   HPA; HPA050660; -.
DR   neXtProt; NX_Q12767; -.
DR   OpenTargets; ENSG00000177728; -.
DR   PharmGKB; PA142671623; -.
DR   eggNOG; KOG4383; Eukaryota.
DR   eggNOG; ENOG410XQVD; LUCA.
DR   GeneTree; ENSGT00390000016550; -.
DR   HOVERGEN; HBG052173; -.
DR   InParanoid; Q12767; -.
DR   PhylomeDB; Q12767; -.
DR   TreeFam; TF314852; -.
DR   ChiTaRS; KIAA0195; human.
DR   GenomeRNAi; 9772; -.
DR   PRO; PR:Q12767; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000177728; -.
DR   CleanEx; HS_KIAA0195; -.
DR   ExpressionAtlas; Q12767; baseline and differential.
DR   Genevisible; Q12767; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   Gene3D; 1.20.1110.10; -; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW   Phosphoprotein; Polymorphism; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1   1356       Transmembrane protein 94.
FT                                /FTId=PRO_0000050731.
FT   TRANSMEM     65     85       Helical. {ECO:0000255}.
FT   TRANSMEM     93    113       Helical. {ECO:0000255}.
FT   TRANSMEM    274    294       Helical. {ECO:0000255}.
FT   TRANSMEM    321    341       Helical. {ECO:0000255}.
FT   TRANSMEM   1093   1113       Helical. {ECO:0000255}.
FT   TRANSMEM   1121   1141       Helical. {ECO:0000255}.
FT   TRANSMEM   1168   1188       Helical. {ECO:0000255}.
FT   TRANSMEM   1229   1249       Helical. {ECO:0000255}.
FT   TRANSMEM   1262   1282       Helical. {ECO:0000255}.
FT   TRANSMEM   1307   1327       Helical. {ECO:0000255}.
FT   MOD_RES     221    221       Phosphoserine.
FT                                {ECO:0000244|PubMed:18691976}.
FT   MOD_RES     225    225       Phosphoserine.
FT                                {ECO:0000244|PubMed:18691976,
FT                                ECO:0000244|PubMed:19369195,
FT                                ECO:0000244|PubMed:24275569}.
FT   MOD_RES     444    444       Phosphoserine.
FT                                {ECO:0000244|PubMed:24275569}.
FT   MOD_RES     445    445       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
FT   MOD_RES     454    454       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
FT   MOD_RES     513    513       Phosphoserine.
FT                                {ECO:0000244|PubMed:21406692}.
FT   MOD_RES     518    518       Phosphoserine.
FT                                {ECO:0000244|PubMed:24275569}.
FT   MOD_RES     798    798       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
FT   MOD_RES     941    941       Phosphoserine.
FT                                {ECO:0000244|PubMed:24275569}.
FT   CARBOHYD    475    475       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    516    516       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1202   1202       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD   1205   1205       N-linked (GlcNAc...). {ECO:0000255}.
FT   VAR_SEQ    1244   1244       T -> TGERAPWEGVDDGGKGAPLWKSDPHIAPPSP (in
FT                                isoform 2). {ECO:0000303|Ref.3}.
FT                                /FTId=VSP_011043.
FT   VARIANT    1040   1040       I -> T (in dbSNP:rs8073809).
FT                                /FTId=VAR_019508.
FT   CONFLICT    203    203       I -> M (in Ref. 2; AAH45540).
FT                                {ECO:0000305}.
FT   CONFLICT    991    991       Q -> L (in Ref. 2; AAH45540).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1356 AA;  151151 MW;  9DC0188CEE81F494 CRC64;
     MDLKEKHLGE PPSALGLSTR KALSVLKEQL EAVLEGHLRE RKKCLTWKEV WRSSFLHHSN
     RCSCFHWPGA SLMLLAVLLL LGCCGGQPAG SRGVGLVNAS ALFLLLLLNL VLIGRQDRLK
     RREVERRLRG IIDQIQDALR DGREIQWPSA MYPDLHMPFA PSWSLHWAYR DGHLVNLPVS
     LLVEGDIIAL RPGQESFASL RGIKDDEHIV LEPGDLFPPF SPPPSPRGEV ERGPQSPQQH
     RLFRVLETPV IDNIRWCLDM ALSRPVTALD NERFTVQSVM LHYAVPVVLA GFLITNALRF
     IFSAPGVTSW QYTLLQLQVN GVLPILPLLF PVLWVLATAC GEARVLAQMS KASPSSLLAK
     FSEDTLSSYT EAVSSQEMLR CIWGHFLRVL GGTSPTLSHS SSLLHSLGSV TVLCCVDKQG
     ILSWPNPSPE TVLFFSGKVE PPHSSHEDLT DGLSTRSFCH PEPHERDALL AGSLNNTLHL
     SNEQERGDWP GEAPKPPEPY SHHKAHGRSK HPSGSNVSFS RDTEGGEEEP SKTQPGMESD
     PYEAEDFVCD YHLEMLSLSQ DQQNPSCIQF DDSNWQLHLT SLKPLGLNVL LNLCDASVTE
     RLCRFSDHLC NIALQESHSA VLPVHVPWGL CELARLIGFT PGAKELFKQE NHLALYRLPS
     AETMKETSLG RLSCVTKRRP PLSHMISLFI KDTTTSTEQM LSHGTADVVL EACTDFWDGA
     DIYPLSGSDR KKVLDFYQRA CLSGYCSAFA YKPMNCALSS QLNGKCIELV QVPGQSSIFT
     MCELPSTIPI KQNARRSSWS SDEGIGEVLE KEDCMQALSG QIFMGMVSSQ YQARLDIVRL
     IDGLVNACIR FVYFSLEDEL KSKVFAEKMG LETGWNCHIS LTPNGDMPGS EIPPSSPSHA
     GSLHDDLNQV SRDDAEGLLL MEEEGHSDLI SFQPTDSDIP SFLEDSNRAK LPRGIHQVRP
     HLQNIDNVPL LVPLFTDCTP ETMCEMIKIM QEYGEVTCCL GSSANLRNSC LFLQSDISIA
     LDPLYPSRCS WETFGYATSI SMAQASDGLS PLQLSGQLNS LPCSLTFRQE ETISIIRLIE
     QARHATYGIR KCFLFLLQCQ LTLVVIQFLS CLVQLPPLLS TTDILWLSCF CYPLLSISLL
     GKPPHSSIMS MATGKNLQSI PKKTQHYFLL CFLLKFSLTI SSCLICFGFT LQSFCDSSRD
     RNLTNCSSVM LPSNDDRAPA WFEDFANGLL SAQKLTAALI VLHTVFISIT HVHRTKPLWR
     KSPLTNLWWA VTVPVVLLGQ VVQTAVDLQL WTHRDSHVHF GLEDVPLLTW LLGCLSLVLV
     VVTNEIVKLH EIRVRVRYQK RQKLQFETKL GMNSPF
//