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UniProtKB - Q12767 (TMM94_HUMAN)

Protein

Transmembrane protein 94

Gene

TMEM94

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 94Imported
Gene namesi
Name:TMEM94Imported
Synonyms:KIAA0195
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000177728.14
HGNCiHGNC:28983 TMEM94
neXtProtiNX_Q12767

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Transmembranei1121 – 1141HelicalSequence analysisAdd BLAST21
Transmembranei1168 – 1188HelicalSequence analysisAdd BLAST21
Transmembranei1229 – 1249HelicalSequence analysisAdd BLAST21
Transmembranei1262 – 1282HelicalSequence analysisAdd BLAST21
Transmembranei1307 – 1327HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9772
OpenTargetsiENSG00000177728
PharmGKBiPA142671623

Polymorphism and mutation databases

BioMutaiKIAA0195
DMDMi2495718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507311 – 1356Transmembrane protein 94Add BLAST1356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei513PhosphoserineCombined sources1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei518PhosphoserineCombined sources1
Modified residuei798PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Glycosylationi1202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1205N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ12767
MaxQBiQ12767
PaxDbiQ12767
PeptideAtlasiQ12767
PRIDEiQ12767
ProteomicsDBi58909
58910 [Q12767-2]

PTM databases

iPTMnetiQ12767
PhosphoSitePlusiQ12767

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

BgeeiENSG00000177728 Expressed in 208 organ(s), highest expression level in right adrenal gland
CleanExiHS_KIAA0195
ExpressionAtlasiQ12767 baseline and differential
GenevisibleiQ12767 HS

Organism-specific databases

HPAiHPA050660

Interactioni

Protein-protein interaction databases

BioGridi115117, 10 interactors
IntActiQ12767, 1 interactor
STRINGi9606.ENSP00000313885

Structurei

3D structure databases

ProteinModelPortaliQ12767
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4383 Eukaryota
ENOG410XQVD LUCA
GeneTreeiENSGT00390000016550
HOVERGENiHBG052173
InParanoidiQ12767
PhylomeDBiQ12767
TreeFamiTF314852

Family and domain databases

InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR023298 ATPase_P-typ_TM_dom_sf
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
SUPFAMiSSF81665 SSF81665, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12767-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLKEKHLGE PPSALGLSTR KALSVLKEQL EAVLEGHLRE RKKCLTWKEV 
        60         70         80         90        100
WRSSFLHHSN RCSCFHWPGA SLMLLAVLLL LGCCGGQPAG SRGVGLVNAS 
       110        120        130        140        150
ALFLLLLLNL VLIGRQDRLK RREVERRLRG IIDQIQDALR DGREIQWPSA 
       160        170        180        190        200
MYPDLHMPFA PSWSLHWAYR DGHLVNLPVS LLVEGDIIAL RPGQESFASL 
       210        220        230        240        250
RGIKDDEHIV LEPGDLFPPF SPPPSPRGEV ERGPQSPQQH RLFRVLETPV 
       260        270        280        290        300
IDNIRWCLDM ALSRPVTALD NERFTVQSVM LHYAVPVVLA GFLITNALRF 
       310        320        330        340        350
IFSAPGVTSW QYTLLQLQVN GVLPILPLLF PVLWVLATAC GEARVLAQMS 
       360        370        380        390        400
KASPSSLLAK FSEDTLSSYT EAVSSQEMLR CIWGHFLRVL GGTSPTLSHS 
       410        420        430        440        450
SSLLHSLGSV TVLCCVDKQG ILSWPNPSPE TVLFFSGKVE PPHSSHEDLT 
       460        470        480        490        500
DGLSTRSFCH PEPHERDALL AGSLNNTLHL SNEQERGDWP GEAPKPPEPY 
       510        520        530        540        550
SHHKAHGRSK HPSGSNVSFS RDTEGGEEEP SKTQPGMESD PYEAEDFVCD 
       560        570        580        590        600
YHLEMLSLSQ DQQNPSCIQF DDSNWQLHLT SLKPLGLNVL LNLCDASVTE 
       610        620        630        640        650
RLCRFSDHLC NIALQESHSA VLPVHVPWGL CELARLIGFT PGAKELFKQE 
       660        670        680        690        700
NHLALYRLPS AETMKETSLG RLSCVTKRRP PLSHMISLFI KDTTTSTEQM 
       710        720        730        740        750
LSHGTADVVL EACTDFWDGA DIYPLSGSDR KKVLDFYQRA CLSGYCSAFA 
       760        770        780        790        800
YKPMNCALSS QLNGKCIELV QVPGQSSIFT MCELPSTIPI KQNARRSSWS 
       810        820        830        840        850
SDEGIGEVLE KEDCMQALSG QIFMGMVSSQ YQARLDIVRL IDGLVNACIR 
       860        870        880        890        900
FVYFSLEDEL KSKVFAEKMG LETGWNCHIS LTPNGDMPGS EIPPSSPSHA 
       910        920        930        940        950
GSLHDDLNQV SRDDAEGLLL MEEEGHSDLI SFQPTDSDIP SFLEDSNRAK 
       960        970        980        990       1000
LPRGIHQVRP HLQNIDNVPL LVPLFTDCTP ETMCEMIKIM QEYGEVTCCL 
      1010       1020       1030       1040       1050
GSSANLRNSC LFLQSDISIA LDPLYPSRCS WETFGYATSI SMAQASDGLS 
      1060       1070       1080       1090       1100
PLQLSGQLNS LPCSLTFRQE ETISIIRLIE QARHATYGIR KCFLFLLQCQ 
      1110       1120       1130       1140       1150
LTLVVIQFLS CLVQLPPLLS TTDILWLSCF CYPLLSISLL GKPPHSSIMS 
      1160       1170       1180       1190       1200
MATGKNLQSI PKKTQHYFLL CFLLKFSLTI SSCLICFGFT LQSFCDSSRD 
      1210       1220       1230       1240       1250
RNLTNCSSVM LPSNDDRAPA WFEDFANGLL SAQKLTAALI VLHTVFISIT 
      1260       1270       1280       1290       1300
HVHRTKPLWR KSPLTNLWWA VTVPVVLLGQ VVQTAVDLQL WTHRDSHVHF 
      1310       1320       1330       1340       1350
GLEDVPLLTW LLGCLSLVLV VVTNEIVKLH EIRVRVRYQK RQKLQFETKL 

GMNSPF
Length:1,356
Mass (Da):151,151
Last modified:November 1, 1997 - v1
Checksum:i9DC0188CEE81F494
GO
Isoform 2 (identifier: Q12767-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1244-1244: T → TGERAPWEGVDDGGKGAPLWKSDPHIAPPSP

Note: No experimental confirmation available.
Show »
Length:1,386
Mass (Da):154,257
Checksum:i7958222BFF279C8D
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JL75C9JL75_HUMAN
Transmembrane protein 94
TMEM94
1,366Annotation score:
J3QQW3J3QQW3_HUMAN
Transmembrane protein 94
TMEM94
1,007Annotation score:
J3QRY7J3QRY7_HUMAN
Transmembrane protein 94
TMEM94
295Annotation score:
J3KTL5J3KTL5_HUMAN
Transmembrane protein 94
TMEM94
176Annotation score:
J3KRN3J3KRN3_HUMAN
Transmembrane protein 94
TMEM94
128Annotation score:
J3QLM7J3QLM7_HUMAN
Transmembrane protein 94
TMEM94
125Annotation score:
J3KS76J3KS76_HUMAN
Transmembrane protein 94
TMEM94
162Annotation score:
J3QS17J3QS17_HUMAN
Transmembrane protein 94
TMEM94
121Annotation score:
J3QSG7J3QSG7_HUMAN
Transmembrane protein 94
TMEM94
256Annotation score:
J3QRT7J3QRT7_HUMAN
Transmembrane protein 94
TMEM94
73Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAA12108 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203I → M in AAH45540 (PubMed:15489334).Curated1
Sequence conflicti991Q → L in AAH45540 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0195081040I → T. Corresponds to variant dbSNP:rs8073809Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0110431244T → TGERAPWEGVDDGGKGAPLW KSDPHIAPPSP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83779 mRNA Translation: BAA12108.2 Different initiation.
BC045540 mRNA Translation: AAH45540.1
AF070545 mRNA Translation: AAC28636.1
CCDSiCCDS32732.1 [Q12767-1]
RefSeqiNP_001308077.1, NM_001321148.1
NP_001308078.1, NM_001321149.1
NP_055553.3, NM_014738.5 [Q12767-1]
UniGeneiHs.514474

Genome annotation databases

EnsembliENST00000314256; ENSP00000313885; ENSG00000177728 [Q12767-1]
GeneIDi9772
KEGGihsa:9772
UCSCiuc002jnz.5 human [Q12767-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83779 mRNA Translation: BAA12108.2 Different initiation.
BC045540 mRNA Translation: AAH45540.1
AF070545 mRNA Translation: AAC28636.1
CCDSiCCDS32732.1 [Q12767-1]
RefSeqiNP_001308077.1, NM_001321148.1
NP_001308078.1, NM_001321149.1
NP_055553.3, NM_014738.5 [Q12767-1]
UniGeneiHs.514474

3D structure databases

ProteinModelPortaliQ12767
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115117, 10 interactors
IntActiQ12767, 1 interactor
STRINGi9606.ENSP00000313885

PTM databases

iPTMnetiQ12767
PhosphoSitePlusiQ12767

Polymorphism and mutation databases

BioMutaiKIAA0195
DMDMi2495718

Proteomic databases

EPDiQ12767
MaxQBiQ12767
PaxDbiQ12767
PeptideAtlasiQ12767
PRIDEiQ12767
ProteomicsDBi58909
58910 [Q12767-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314256; ENSP00000313885; ENSG00000177728 [Q12767-1]
GeneIDi9772
KEGGihsa:9772
UCSCiuc002jnz.5 human [Q12767-1]

Organism-specific databases

CTDi9772
DisGeNETi9772
EuPathDBiHostDB:ENSG00000177728.14
GeneCardsiTMEM94
HGNCiHGNC:28983 TMEM94
HPAiHPA050660
neXtProtiNX_Q12767
OpenTargetsiENSG00000177728
PharmGKBiPA142671623
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4383 Eukaryota
ENOG410XQVD LUCA
GeneTreeiENSGT00390000016550
HOVERGENiHBG052173
InParanoidiQ12767
PhylomeDBiQ12767
TreeFamiTF314852

Miscellaneous databases

ChiTaRSiTMEM94 human
GenomeRNAii9772
PROiPR:Q12767

Gene expression databases

BgeeiENSG00000177728 Expressed in 208 organ(s), highest expression level in right adrenal gland
CleanExiHS_KIAA0195
ExpressionAtlasiQ12767 baseline and differential
GenevisibleiQ12767 HS

Family and domain databases

InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR023298 ATPase_P-typ_TM_dom_sf
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
SUPFAMiSSF81665 SSF81665, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTMM94_HUMAN
AccessioniPrimary (citable) accession number: Q12767
Secondary accession number(s): O75536, Q86XF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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