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Entry version 137 (16 Oct 2019)
Sequence version 2 (13 Nov 2007)
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Protein

HMG domain-containing protein 3

Gene

HMGXB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi288 – 356HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HMG domain-containing protein 3
Alternative name(s):
HMG box-containing protein 3
Protein SMF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMGXB3
Synonyms:KIAA0194, SMF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28982 HMGXB3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12766

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22993

Open Targets

More...
OpenTargetsi
ENSG00000113716

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720627

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12766

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HMGXB3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160112910

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000488061 – 1538HMG domain-containing protein 3Add BLAST1538

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12766

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12766

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12766

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12766

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12766

PeptideAtlas

More...
PeptideAtlasi
Q12766

PRoteomics IDEntifications database

More...
PRIDEi
Q12766

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
34082
58908 [Q12766-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12766

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12766

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113716 Expressed in 228 organ(s), highest expression level in olfactory bulb

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12766 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12766 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005967

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116640, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q12766, 8 interactors

Molecular INTeraction database

More...
MINTi
Q12766

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000421917

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi62 – 239Arg-richAdd BLAST178
Compositional biasi276 – 282Poly-Lys7
Compositional biasi518 – 524Poly-Ser7
Compositional biasi1523 – 1532Poly-Glu10

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF99 Eukaryota
ENOG410XVX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006983

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112914

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12766

Identification of Orthologs from Complete Genome Data

More...
OMAi
MESEAIE

Database of Orthologous Groups

More...
OrthoDBi
188302at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12766

TreeFam database of animal gene trees

More...
TreeFami
TF330893

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR039598 HMGXB3
IPR040648 HMGXB3_CxC4

The PANTHER Classification System

More...
PANTHERi
PTHR17609 PTHR17609, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18717 CxC4, 1 hit
PF09011 HMG_box_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRTQPRPCY LNAPQQCPGA ERPGRPTAGS HSFLLRPGPL AGSSPFALLD
60 70 80 90 100
PLQAFEQFVW VRSQARAGLL RLRQGSHAVT RCRPLPVRRE GRRDGSPWRS
110 120 130 140 150
VVCRYCRCSR QTGASVTTVS LPSSSSSPGL DPRGPRQASV RSLRSEPVLL
160 170 180 190 200
FLPFRTPYRD SEEGKREGLS RLRAVCRRAG PRGRGSFSPR DARASPRLHF
210 220 230 240 250
LVAAVTTGAA SRRQRGARVR QPSPSSSRRA KRLRECERRS LHAPPAMDAS
260 270 280 290 300
YDGTEVTVVM EEIEEAYCYT SPGPPKKKKK YKIHGEKTKK PRSAYLLYYY
310 320 330 340 350
DIYLKVQQEL PHLPQSEINK KISESWRLLS VAERSYYLEK AKLEKEGLDP
360 370 380 390 400
NSKLSALTAV VPDIPGFRKI LPRSDYIIIP KSSLQEDRSC PQLELCVAQN
410 420 430 440 450
QMSPKGPPLV SNTAPETVPS HAGMAEQCLA VEALAEEVGA LTQSGAVQEI
460 470 480 490 500
ATSEILSQDV LLEDASLEVG ESHQPYQTSL VIEETLVNGS PDLPTGSLAV
510 520 530 540 550
PHPQVGESVS VVTVMRDSSE SSSSAPATQF IMLPLPAYSV VENPTSIKLT
560 570 580 590 600
TTYTRRGHGT CTSPGCSFTY VTRHKPPKCP TCGNFLGGKW IPKEKPAKVK
610 620 630 640 650
VELASGVSSK GSVVKRNQQP VTTEQNSSKE NASKLTLENS EAVSQLLNVA
660 670 680 690 700
PPREVGEESE WEEVIISDAH VLVKEAPGNC GTAVTKTPVV KSGVQPEVTL
710 720 730 740 750
GTTDNDSPGA DVPTPSEGTS TSSPLPAPKK PTGADLLTPG SRAPELKGRA
760 770 780 790 800
RGKPSLLAAA RPMRAILPAP VNVGRGSSMG LPRARQAFSL SDKTPSVRTC
810 820 830 840 850
GLKPSTLKQL GQPIQQPSGP GEVKLPSGPS NRTSQVKVVE VKPDMFPPYK
860 870 880 890 900
YSCTVTLDLG LATSRGRGKC KNPSCSYVYT NRHKPRICPS CGVNLAKDRT
910 920 930 940 950
EKTTKAIEVS SPLPDVLNAT EPLSTAQREI QRQSTLQLLR KVLQIPENES
960 970 980 990 1000
ELAEVFALIH ELNSSRLILS NVSEETVTIE QTSWSNYYES PSTQCLLCSS
1010 1020 1030 1040 1050
PLFKGGQNSL AGPQECWLLT ASRLQTVTAQ VKMCLNPHCL ALHSFIDIYT
1060 1070 1080 1090 1100
GLFNVGNKLL VSLDLLFAIR NQIKLGEDPR VSINVVLKSV QEQTEKTLTS
1110 1120 1130 1140 1150
EELSQLQELL CNGYWAFECL TVRDYNDMIC GICGVAPKVE MAQRSEENVL
1160 1170 1180 1190 1200
ALKSVEFTWP EFLGSNEVNV EDFWATMETE VIEQVAFPAS IPITKFDASV
1210 1220 1230 1240 1250
IAPFFPPLMR GAVVVNTEKD KNLDVQPVPG SGSALVRLLQ EGTCKLDEIG
1260 1270 1280 1290 1300
SYSEEKLQHL LRQCGIPFGA EDSKDQLCFS LLALYESVQN GARAIRPPRH
1310 1320 1330 1340 1350
FTGGKIYKVC PHQVVCGSKY LVRGESARDH VDLLASSRHW PPVYVVDMAT
1360 1370 1380 1390 1400
SVALCADLCY PELTNQMWGR NQGCFSSPTE PPVSVSCPEL LDQHYTVDMT
1410 1420 1430 1440 1450
ETEHSIQHPV TKTATRRIVH AGLQPNPGDP SAGHHSLALC PELAPYATIL
1460 1470 1480 1490 1500
ASIVDSKPNG VRQRPIAFDN ATHYYLYNRL MDFLTSREIV NRQIHDIVQS
1510 1520 1530
CQPGEVVIRD TLYRLGVAQI KTETEEEGEE EEVAAVAE
Length:1,538
Mass (Da):168,334
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i966C2EBE269BA118
GO
Isoform 2 (identifier: Q12766-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.

Note: No experimental confirmation available.
Show »
Length:1,292
Mass (Da):141,106
Checksum:i2C390765939C81E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PEK0E9PEK0_HUMAN
HMG domain-containing protein 3
HMGXB3
1,260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAC2H0YAC2_HUMAN
HMG domain-containing protein 3
HMGXB3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti734A → V in AAH51025 (Ref. 2) Curated1
Sequence conflicti734A → V in BAA12107 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473371 – 246Missing in isoform 2. CuratedAdd BLAST246

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011406 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61752.1
BC051025 mRNA Translation: AAH51025.1
D83778 mRNA Translation: BAA12107.1
U63963 Genomic DNA Translation: AAB51697.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54935.1 [Q12766-2]

NCBI Reference Sequences

More...
RefSeqi
NP_055798.2, NM_014983.2 [Q12766-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000502717; ENSP00000421917; ENSG00000113716 [Q12766-2]
ENST00000613459; ENSP00000479027; ENSG00000113716 [Q12766-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22993

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22993

UCSC genome browser

More...
UCSCi
uc003lrk.5 human [Q12766-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011406 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61752.1
BC051025 mRNA Translation: AAH51025.1
D83778 mRNA Translation: BAA12107.1
U63963 Genomic DNA Translation: AAB51697.1
CCDSiCCDS54935.1 [Q12766-2]
RefSeqiNP_055798.2, NM_014983.2 [Q12766-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116640, 6 interactors
IntActiQ12766, 8 interactors
MINTiQ12766
STRINGi9606.ENSP00000421917

PTM databases

iPTMnetiQ12766
PhosphoSitePlusiQ12766

Polymorphism and mutation databases

BioMutaiHMGXB3
DMDMi160112910

Proteomic databases

EPDiQ12766
jPOSTiQ12766
MassIVEiQ12766
MaxQBiQ12766
PaxDbiQ12766
PeptideAtlasiQ12766
PRIDEiQ12766
ProteomicsDBi34082
58908 [Q12766-1]

Genome annotation databases

EnsembliENST00000502717; ENSP00000421917; ENSG00000113716 [Q12766-2]
ENST00000613459; ENSP00000479027; ENSG00000113716 [Q12766-1]
GeneIDi22993
KEGGihsa:22993
UCSCiuc003lrk.5 human [Q12766-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22993
DisGeNETi22993

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HMGXB3
HGNCiHGNC:28982 HMGXB3
HPAiHPA005967
neXtProtiNX_Q12766
OpenTargetsiENSG00000113716
PharmGKBiPA164720627

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF99 Eukaryota
ENOG410XVX8 LUCA
GeneTreeiENSGT00390000006983
HOGENOMiHOG000112914
InParanoidiQ12766
OMAiMESEAIE
OrthoDBi188302at2759
PhylomeDBiQ12766
TreeFamiTF330893

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HMGXB3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22993
PharosiQ12766

Protein Ontology

More...
PROi
PR:Q12766

Gene expression databases

BgeeiENSG00000113716 Expressed in 228 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiQ12766 baseline and differential
GenevisibleiQ12766 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR039598 HMGXB3
IPR040648 HMGXB3_CxC4
PANTHERiPTHR17609 PTHR17609, 1 hit
PfamiView protein in Pfam
PF18717 CxC4, 1 hit
PF09011 HMG_box_2, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMGX3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12766
Secondary accession number(s): G5E9Y4, Q86UG3, Q9UMF4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 13, 2007
Last modified: October 16, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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