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Protein

Secernin-1

Gene

SCRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).By similarity

Miscellaneous

'Secern' is an archaic English term meaning 'secrete'.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis

Protein family/group databases

MEROPSiC69.003

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-1
Gene namesi
Name:SCRN1
Synonyms:KIAA0193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136193.16
HGNCiHGNC:22192 SCRN1
MIMi614965 gene
neXtProtiNX_Q12765

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9805
OpenTargetsiENSG00000136193
PharmGKBiPA134874373

Polymorphism and mutation databases

BioMutaiSCRN1
DMDMi30923294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002214362 – 414Secernin-1Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ12765
MaxQBiQ12765
PaxDbiQ12765
PeptideAtlasiQ12765
PRIDEiQ12765
ProteomicsDBi58907

2D gel databases

OGPiQ12765

PTM databases

iPTMnetiQ12765
PhosphoSitePlusiQ12765

Expressioni

Gene expression databases

BgeeiENSG00000136193 Expressed in 232 organ(s), highest expression level in cerebellum
CleanExiHS_SCRN1
ExpressionAtlasiQ12765 baseline and differential
GenevisibleiQ12765 HS

Organism-specific databases

HPAiHPA024517

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GORASP1Q9BQQ33EBI-2690712,EBI-2561458

Protein-protein interaction databases

BioGridi115145, 26 interactors
IntActiQ12765, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ12765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGQK Eukaryota
COG4690 LUCA
GeneTreeiENSGT00390000013474
HOGENOMiHOG000223307
HOVERGENiHBG056050
InParanoidiQ12765
KOiK14358
OMAiSLPCIHY
OrthoDBiEOG091G06OR
PhylomeDBiQ12765
TreeFamiTF323890

Family and domain databases

InterProiView protein in InterPro
IPR005322 Peptidase_C69
PANTHERiPTHR12994 PTHR12994, 1 hit
PfamiView protein in Pfam
PF03577 Peptidase_C69, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12765-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPPSYCF VAFPPRAKDG LVVFGKNSAR PRDEVQEVVY FSAADHEPES
60 70 80 90 100
KVECTYISID QVPRTYAIMI SRPAWLWGAE MGANEHGVCI ANEAINTREP
110 120 130 140 150
AAEIEALLGM DLVRLGLERG ETAKEALDVI VSLLEEHGQG GNYFEDANSC
160 170 180 190 200
HSFQSAYLIV DRDEAWVLET IGKYWAAEKV TEGVRCICSQ LSLTTKMDAE
210 220 230 240 250
HPELRSYAQS QGWWTGEGEF NFSEVFSPVE DHLDCGAGKD SLEKQEESIT
260 270 280 290 300
VQTMMNTLRD KASGVCIDSE FFLTTASGVS VLPQNRSSPC IHYFTGTPDP
310 320 330 340 350
SRSIFKPFIF VDDVKLVPKT QSPCFGDDDP AKKEPRFQEK PDRRHELYKA
360 370 380 390 400
HEWARAIIES DQEQGRKLRS TMLELEKQGL EAMEEILTSS EPLDPAEVGD
410
LFYDCVDTEI KFFK
Length:414
Mass (Da):46,382
Last modified:May 16, 2003 - v2
Checksum:i1B14D1007AE6BEBE
GO
Isoform 2 (identifier: Q12765-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVQDGTFKTRDSTWTCESTRM

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):48,714
Checksum:i4B4A4778214208C1
GO
Isoform 3 (identifier: Q12765-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,864
Checksum:iA45FC07486234093
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7U9C9J7U9_HUMAN
Secernin-1
SCRN1
141Annotation score:
C9K052C9K052_HUMAN
Secernin-1
SCRN1
245Annotation score:
B8ZZP4B8ZZP4_HUMAN
Secernin-1
SCRN1
140Annotation score:

Sequence cautioni

The sequence BAA12106 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120G → W in BAG58182 (PubMed:14702039).Curated1
Sequence conflicti298P → H in AAH40492 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057709189S → N. Corresponds to variant dbSNP:rs35960711Ensembl.1
Natural variantiVAR_029512338Q → R. Corresponds to variant dbSNP:rs17324153Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0444531 – 68Missing in isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_0444541M → MVQDGTFKTRDSTWTCESTR M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071705 mRNA Translation: BAE91926.1
D83777 mRNA Translation: BAA12106.2 Different initiation.
AK289514 mRNA Translation: BAF82203.1
AK295172 mRNA Translation: BAG58182.1
AK295713 mRNA Translation: BAG58557.1
AC004912 Genomic DNA Translation: AAQ96874.1
AC007285 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93926.1
CH471073 Genomic DNA Translation: EAW93928.1
BC040492 mRNA Translation: AAH40492.1
CCDSiCCDS47567.1 [Q12765-2]
CCDS47568.1 [Q12765-3]
CCDS5422.1 [Q12765-1]
RefSeqiNP_001138985.1, NM_001145513.1 [Q12765-1]
NP_001138986.1, NM_001145514.1 [Q12765-2]
NP_001138987.1, NM_001145515.1 [Q12765-3]
NP_055581.3, NM_014766.4 [Q12765-1]
UniGeneiHs.520740

Genome annotation databases

EnsembliENST00000242059; ENSP00000242059; ENSG00000136193 [Q12765-1]
ENST00000409497; ENSP00000386872; ENSG00000136193 [Q12765-1]
ENST00000425819; ENSP00000414245; ENSG00000136193 [Q12765-3]
ENST00000426154; ENSP00000409068; ENSG00000136193 [Q12765-1]
ENST00000434476; ENSP00000388942; ENSG00000136193 [Q12765-2]
GeneIDi9805
KEGGihsa:9805
UCSCiuc003tak.4 human [Q12765-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071705 mRNA Translation: BAE91926.1
D83777 mRNA Translation: BAA12106.2 Different initiation.
AK289514 mRNA Translation: BAF82203.1
AK295172 mRNA Translation: BAG58182.1
AK295713 mRNA Translation: BAG58557.1
AC004912 Genomic DNA Translation: AAQ96874.1
AC007285 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93926.1
CH471073 Genomic DNA Translation: EAW93928.1
BC040492 mRNA Translation: AAH40492.1
CCDSiCCDS47567.1 [Q12765-2]
CCDS47568.1 [Q12765-3]
CCDS5422.1 [Q12765-1]
RefSeqiNP_001138985.1, NM_001145513.1 [Q12765-1]
NP_001138986.1, NM_001145514.1 [Q12765-2]
NP_001138987.1, NM_001145515.1 [Q12765-3]
NP_055581.3, NM_014766.4 [Q12765-1]
UniGeneiHs.520740

3D structure databases

ProteinModelPortaliQ12765
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115145, 26 interactors
IntActiQ12765, 4 interactors

Protein family/group databases

MEROPSiC69.003

PTM databases

iPTMnetiQ12765
PhosphoSitePlusiQ12765

Polymorphism and mutation databases

BioMutaiSCRN1
DMDMi30923294

2D gel databases

OGPiQ12765

Proteomic databases

EPDiQ12765
MaxQBiQ12765
PaxDbiQ12765
PeptideAtlasiQ12765
PRIDEiQ12765
ProteomicsDBi58907

Protocols and materials databases

DNASUi9805
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242059; ENSP00000242059; ENSG00000136193 [Q12765-1]
ENST00000409497; ENSP00000386872; ENSG00000136193 [Q12765-1]
ENST00000425819; ENSP00000414245; ENSG00000136193 [Q12765-3]
ENST00000426154; ENSP00000409068; ENSG00000136193 [Q12765-1]
ENST00000434476; ENSP00000388942; ENSG00000136193 [Q12765-2]
GeneIDi9805
KEGGihsa:9805
UCSCiuc003tak.4 human [Q12765-1]

Organism-specific databases

CTDi9805
DisGeNETi9805
EuPathDBiHostDB:ENSG00000136193.16
GeneCardsiSCRN1
HGNCiHGNC:22192 SCRN1
HPAiHPA024517
MIMi614965 gene
neXtProtiNX_Q12765
OpenTargetsiENSG00000136193
PharmGKBiPA134874373
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQK Eukaryota
COG4690 LUCA
GeneTreeiENSGT00390000013474
HOGENOMiHOG000223307
HOVERGENiHBG056050
InParanoidiQ12765
KOiK14358
OMAiSLPCIHY
OrthoDBiEOG091G06OR
PhylomeDBiQ12765
TreeFamiTF323890

Miscellaneous databases

ChiTaRSiSCRN1 human
GeneWikiiSCRN1
GenomeRNAii9805
PROiPR:Q12765
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136193 Expressed in 232 organ(s), highest expression level in cerebellum
CleanExiHS_SCRN1
ExpressionAtlasiQ12765 baseline and differential
GenevisibleiQ12765 HS

Family and domain databases

InterProiView protein in InterPro
IPR005322 Peptidase_C69
PANTHERiPTHR12994 PTHR12994, 1 hit
PfamiView protein in Pfam
PF03577 Peptidase_C69, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCRN1_HUMAN
AccessioniPrimary (citable) accession number: Q12765
Secondary accession number(s): A8K0E9
, B4DHM0, B4DIP5, C9JPG0, Q25QX7, Q8IWD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2003
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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