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Entry version 161 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Transcriptional activator HAA1

Gene

HAA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper.1 Publication

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi11ZincPROSITE-ProRule annotation1
Metal bindingi14ZincPROSITE-ProRule annotation1
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi25ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1 – 40Copper-fistPROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional activator HAA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAA1
Ordered Locus Names:YPR008W
ORF Names:LPZ8W, YP9531.01, YP9723.08
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YPR008W

Saccharomyces Genome Database

More...
SGDi
S000006212, HAA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949331 – 694Transcriptional activator HAA1Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei125PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12753

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12753

PRoteomics IDEntifications database

More...
PRIDEi
Q12753

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12753

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36186, 71 interactors

Database of interacting proteins

More...
DIPi
DIP-1462N

Protein interaction database and analysis system

More...
IntActi
Q12753, 8 interactors

Molecular INTeraction database

More...
MINTi
Q12753

STRING: functional protein association networks

More...
STRINGi
4932.YPR008W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12753, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12753

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S7CA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176728

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022338_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12753

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISKDYHH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.430.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001083, Cu_fist_DNA-bd_dom
IPR036395, Cu_fist_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00649, Copper-fist, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00617, COPPERFIST

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01090, Copper-fist, 1 hit
SM00412, Cu_FIST, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57879, SSF57879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01119, COPPER_FIST_1, 1 hit
PS50073, COPPER_FIST_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLINGIKYA CERCIRGHRV TTCNHTDQPL MMIKPKGRPS TTCDYCKQLR
60 70 80 90 100
KNKNANPEGV CTCGRLEKKK LAQKAKEEAR AKAKEKQRKQ CTCGTDEVCK
110 120 130 140 150
YHAQKRHLRK SPSSSQKKGR SISRSQPMFE RVLSSTSLDS NMLSGHGALS
160 170 180 190 200
DTSSILTSTF LDSEPGVGKI SKDYHHVPSL ASISSLQSSQ SLDQNFSIPQ
210 220 230 240 250
SPPLSSMSFN FLTGNINETN QNHSNHQHSK SGNNWQDSSV SLPAKADSRL
260 270 280 290 300
NMMDKNNSVG LDLLGHSKRI SPISNSRVGE VSVPLEEYIP SDIDGVGRVT
310 320 330 340 350
DKSSLVYDWP FDESIERNFS TTATAATGES KFDINDNCNR INSKSYSKTN
360 370 380 390 400
SMNGNGMNNS NNNNINSNGN DKNNNNSSRQ EHQGNGLFDM FTDSSSISTL
410 420 430 440 450
SRANLLLQEK IGSQENSVKQ ENYSKNPQLR HQLTSRSRSF IHHPANEYLK
460 470 480 490 500
NTFGNSHSND IGKGVEVLSL TPSFMDIPEK ERETERSPSS NYITDRPFTR
510 520 530 540 550
KPRSSSIDVN HRYPPMAPTT VATSPGALNN AVASNLDDQL SLTSLNSQPS
560 570 580 590 600
SIANMMMDPS NLAEQSSIHS VPQSINSPRM PKTGSRQDKN IHTKKEERNP
610 620 630 640 650
LNNIHDLSQL ENVPDEMNQM FSPPLKSMNR PDAIRENSSS SNFIIQGNSM
660 670 680 690
ISTPSGRNDL PDTSPMSSIQ TASPPSQLLT DQGFADLDNF MSSL
Length:694
Mass (Da):76,671
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A129F79B4E99CA8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U31900 Genomic DNA Translation: AAA97587.1
Z71255 Genomic DNA Translation: CAA95048.1
Z48951 Genomic DNA Translation: CAA88786.1
Z49919 Genomic DNA Translation: CAA90152.1
AY692804 Genomic DNA Translation: AAT92823.1
BK006949 Genomic DNA Translation: DAA11435.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59753

NCBI Reference Sequences

More...
RefSeqi
NP_015333.1, NM_001184105.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR008W_mRNA; YPR008W; YPR008W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856117

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR008W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31900 Genomic DNA Translation: AAA97587.1
Z71255 Genomic DNA Translation: CAA95048.1
Z48951 Genomic DNA Translation: CAA88786.1
Z49919 Genomic DNA Translation: CAA90152.1
AY692804 Genomic DNA Translation: AAT92823.1
BK006949 Genomic DNA Translation: DAA11435.1
PIRiS59753
RefSeqiNP_015333.1, NM_001184105.1

3D structure databases

SMRiQ12753
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36186, 71 interactors
DIPiDIP-1462N
IntActiQ12753, 8 interactors
MINTiQ12753
STRINGi4932.YPR008W

PTM databases

iPTMnetiQ12753

Proteomic databases

MaxQBiQ12753
PaxDbiQ12753
PRIDEiQ12753

Genome annotation databases

EnsemblFungiiYPR008W_mRNA; YPR008W; YPR008W
GeneIDi856117
KEGGisce:YPR008W

Organism-specific databases

EuPathDBiFungiDB:YPR008W
SGDiS000006212, HAA1

Phylogenomic databases

eggNOGiENOG502S7CA, Eukaryota
GeneTreeiENSGT00940000176728
HOGENOMiCLU_022338_0_0_1
InParanoidiQ12753
OMAiISKDYHH

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12753
RNActiQ12753, protein

Family and domain databases

Gene3Di3.90.430.10, 1 hit
InterProiView protein in InterPro
IPR001083, Cu_fist_DNA-bd_dom
IPR036395, Cu_fist_DNA-bd_dom_sf
PfamiView protein in Pfam
PF00649, Copper-fist, 1 hit
PRINTSiPR00617, COPPERFIST
SMARTiView protein in SMART
SM01090, Copper-fist, 1 hit
SM00412, Cu_FIST, 1 hit
SUPFAMiSSF57879, SSF57879, 1 hit
PROSITEiView protein in PROSITE
PS01119, COPPER_FIST_1, 1 hit
PS50073, COPPER_FIST_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAA1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12753
Secondary accession number(s): D6W419
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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