UniProtKB - Q12743 (DFM1_YEAST)
Protein
DER1-like family member protein 1
Gene
DFM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins.1 Publication
GO - Molecular functioni
- misfolded protein binding Source: GO_Central
- protein-containing complex binding Source: SGD
- ubiquitin-specific protease binding Source: GO_Central
GO - Biological processi
- endoplasmic reticulum unfolded protein response Source: SGD
- regulation of retrograde protein transport, ER to cytosol Source: SGD
- ubiquitin-dependent ERAD pathway Source: SGD
Keywordsi
Biological process | Stress response |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29954-MONOMER |
Protein family/group databases
TCDBi | 3.A.16.1.2, the endoplasmic reticular retrotranslocon (er-rt) family |
Names & Taxonomyi
Protein namesi | Recommended name: DER1-like family member protein 1 |
Gene namesi | Name:DFM1 Ordered Locus Names:YDR411C ORF Names:D9461.2 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002819, DFM1 |
VEuPathDBi | FungiDB:YDR411C |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- Hrd1p ubiquitin ligase ERAD-L complex Source: GO_Central
- integral component of endoplasmic reticulum membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 122 | LumenalSequence analysisAdd BLAST | 60 | |
Transmembranei | 123 – 143 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 170 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 171 – 191 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 192 | LumenalSequence analysis | 1 | |
Transmembranei | 193 – 213 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 214 – 341 | CytoplasmicSequence analysisAdd BLAST | 128 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219054 | 1 – 341 | DER1-like family member protein 1Add BLAST | 341 |
Proteomic databases
PaxDbi | Q12743 |
PRIDEi | Q12743 |
PTM databases
iPTMneti | Q12743 |
Expressioni
Inductioni
By endoplasmic reticulum stress.1 Publication
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- misfolded protein binding Source: GO_Central
- ubiquitin-specific protease binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 32471, 81 interactors |
IntActi | Q12743, 15 interactors |
MINTi | Q12743 |
STRINGi | 4932.YDR411C |
Miscellaneous databases
RNActi | Q12743, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the derlin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0858, Eukaryota |
GeneTreei | ENSGT00530000063156 |
HOGENOMi | CLU_059047_0_0_1 |
InParanoidi | Q12743 |
OMAi | WRIFTSC |
Family and domain databases
InterProi | View protein in InterPro IPR007599, DER1 |
Pfami | View protein in Pfam PF04511, DER1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q12743-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGPRNVRTL HGNGGRNNDV MGPKEFWLNI PPITRTLFTL AIVMTIVGRL
60 70 80 90 100
NLINPWYFIY VWNLTFKKVQ IWRLLTSCVM LSSRAMPALM ELYSIYDRSS
110 120 130 140 150
QLERGHFGPG LSNRRGPMVT VDYAYYLCFC ILAITTATTI IYGSYYPVVL
160 170 180 190 200
TSGFISCITY TWSIDNANVQ IMFYGLIPVW GKYFPLIQLF ISFVFNEGDF
210 220 230 240 250
VISLIGFTTG YLYTCLDTHT LGPIWGMISR KADPTYGISP NGKFSTPWWF
260 270 280 290 300
TSLYARITGA HNETATFNNN FANVPSSQRE TRTFSGRGQR LGTAPATLSQ
310 320 330 340
TSGTDSGRAS GSQLRSGPSN LNQFQGRGQR VGQTNSPSDS Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33007 Genomic DNA Translation: AAB64889.1 L07952 Unassigned DNA Translation: AAA16518.1 BK006938 Genomic DNA Translation: DAA12253.1 |
PIRi | S69696 |
RefSeqi | NP_010699.1, NM_001180719.1 |
Genome annotation databases
EnsemblFungii | YDR411C_mRNA; YDR411C; YDR411C |
GeneIDi | 852020 |
KEGGi | sce:YDR411C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33007 Genomic DNA Translation: AAB64889.1 L07952 Unassigned DNA Translation: AAA16518.1 BK006938 Genomic DNA Translation: DAA12253.1 |
PIRi | S69696 |
RefSeqi | NP_010699.1, NM_001180719.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 32471, 81 interactors |
IntActi | Q12743, 15 interactors |
MINTi | Q12743 |
STRINGi | 4932.YDR411C |
Protein family/group databases
TCDBi | 3.A.16.1.2, the endoplasmic reticular retrotranslocon (er-rt) family |
PTM databases
iPTMneti | Q12743 |
Proteomic databases
PaxDbi | Q12743 |
PRIDEi | Q12743 |
Genome annotation databases
EnsemblFungii | YDR411C_mRNA; YDR411C; YDR411C |
GeneIDi | 852020 |
KEGGi | sce:YDR411C |
Organism-specific databases
SGDi | S000002819, DFM1 |
VEuPathDBi | FungiDB:YDR411C |
Phylogenomic databases
eggNOGi | KOG0858, Eukaryota |
GeneTreei | ENSGT00530000063156 |
HOGENOMi | CLU_059047_0_0_1 |
InParanoidi | Q12743 |
OMAi | WRIFTSC |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29954-MONOMER |
Miscellaneous databases
PROi | PR:Q12743 |
RNActi | Q12743, protein |
Family and domain databases
InterProi | View protein in InterPro IPR007599, DER1 |
Pfami | View protein in Pfam PF04511, DER1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DFM1_YEAST | |
Accessioni | Q12743Primary (citable) accession number: Q12743 Secondary accession number(s): D6VT43, Q7LIJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - SIMILARITY comments
Index of protein domains and families - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names