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Protein

DNA polymerase gamma

Gene

mip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the replication of mitochondrial DNA.

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mitochondrial DNA replication Source: PomBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication
LigandMagnesium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase gamma (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mip1
ORF Names:SPCC24B10.22, SPCPB16A4.01
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPCC24B10.22

Schizosaccharomyces pombe database

More...
PomBasei
SPCC24B10.22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001012771 – 1018DNA polymerase gammaAdd BLAST1018

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12704

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12704

PRoteomics IDEntifications database

More...
PRIDEi
Q12704

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12704

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
275671, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPCC24B10.22.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q12704

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000176668

KEGG Orthology (KO)

More...
KOi
K02332

Identification of Orthologs from Complete Genome Data

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OMAi
PKWYKDL

Database of Orthologous Groups

More...
OrthoDBi
EOG092C03LT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12704

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002297 DNA-dir_DNA_pol_A_mt
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR012337 RNaseH-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10267 PTHR10267, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00476 DNA_pol_A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00867 DNAPOLG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00482 POLAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12704-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFYKACPSTL TCSKWIHSII KTKKFLYCRH YSSKSFIDNA PLRINPVGVQ
60 70 80 90 100
YLSPALQNQV FPQQNTQISQ LHLDLAKFHL AKHQLLNKET IKLPSFNFRL
110 120 130 140 150
PPLQGKTISE HFYNIGLEFA EPHLSKAIKF SKIDTPVQPK TWKRQPGWTK
160 170 180 190 200
YAKDGSISCV PYPDSDCMVF DVEVLYKVSP FAVVATAVSE DAWYCWLSPW
210 220 230 240 250
LLGKSENDRQ LIPSNPKGAL FVGHNVSFDR QRIREEYNIK SSRNVFLDTM
260 270 280 290 300
SLHVATHGMC SRQKPTWFKA RKAYIRSQST ETSEDDDSSS FDDDYQNYLK
310 320 330 340 350
QEPWLAHSSV NSLKDVAKFH CNITLDKSKR DDFASLEKEP ILQKLNELIT
360 370 380 390 400
YCAHDTYSTH QVFKKVFPQF LEVCPHPATF SAMLSLGSVF LPVNHSWTRY
410 420 430 440 450
INGVEEQYQQ MIQLVDQKLS QYAEKAKDLI NTKDTVLKDP WLRQLDWTPC
460 470 480 490 500
NLYRKLKKAT QEVPVVPKWY KKAYCKTEKR AVITAKSRLA PILLRLKWKK
510 520 530 540 550
HPLAWSDTYG WVFSVERTSK DEIEMLLDQG LVPCSREEDT KLDYNNYIFF
560 570 580 590 600
KVPHKDGPEA RCGSPLSKSY QRYFEEGILQ SDYEVAKKAL EMSASCSYWS
610 620 630 640 650
SARDRIRSQM VVWDKDAELG VPSSVDGFGI ILPCIIPMGT VTRRAVENTW
660 670 680 690 700
LTASNSKKNR LGSELKAMIR APDGYTFVGA DVDSEELWIV ALMGDSQFRL
710 720 730 740 750
HGATALGMMT LEGKKSEGTD LHSKTAAILG VSRDSAKVFN YGRLYGAGLK
760 770 780 790 800
HTTLLLMQMN PTLKTAEAKE LAKKLYASTK GVKSKMSKRL QEMGLPKLTF
810 820 830 840 850
WSQGTESFVF NKLEAMAQLP SPRTPVLDAG ITQALSSKNL SKNSFMTSRV
860 870 880 890 900
NWAIQSSAVD YLHLLLVSMN HLIKKYYLEA RLSLTVHDEV RYLSSDKDKY
910 920 930 940 950
RVAFALQVAN LWTRAFFCQR LGINELPQSV AFFSSVDIDH VLRKDVKMDC
960 970 980 990 1000
VTPSNKVPIP PGEELTIESV LEKLEQSGQS LEPLEQIQCF VDVKATTSAE
1010
ITEEDKKNIA YLKAQAFY
Length:1,018
Mass (Da):116,045
Last modified:March 5, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B114BC6FBEE63CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti563G → C in CAA88012 (PubMed:7489897).Curated1
Sequence conflicti571 – 572QR → HA in CAA88012 (PubMed:7489897).Curated2
Sequence conflicti832T → Q in CAA88012 (PubMed:7489897).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z47976 Genomic DNA Translation: CAA88012.1
CU329672 Genomic DNA Translation: CAB76231.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4375
T50429

NCBI Reference Sequences

More...
RefSeqi
NP_588025.2, NM_001023016.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC24B10.22.1; SPCC24B10.22.1:pep; SPCC24B10.22

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539099

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC24B10.22

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47976 Genomic DNA Translation: CAA88012.1
CU329672 Genomic DNA Translation: CAB76231.1
PIRiJC4375
T50429
RefSeqiNP_588025.2, NM_001023016.2

3D structure databases

ProteinModelPortaliQ12704
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275671, 1 interactor
STRINGi4896.SPCC24B10.22.1

PTM databases

iPTMnetiQ12704

Proteomic databases

MaxQBiQ12704
PaxDbiQ12704
PRIDEiQ12704

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC24B10.22.1; SPCC24B10.22.1:pep; SPCC24B10.22
GeneIDi2539099
KEGGispo:SPCC24B10.22

Organism-specific databases

EuPathDBiFungiDB:SPCC24B10.22
PomBaseiSPCC24B10.22

Phylogenomic databases

HOGENOMiHOG000176668
KOiK02332
OMAiPKWYKDL
OrthoDBiEOG092C03LT
PhylomeDBiQ12704

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12704

Family and domain databases

InterProiView protein in InterPro
IPR002297 DNA-dir_DNA_pol_A_mt
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR012337 RNaseH-like_sf
PANTHERiPTHR10267 PTHR10267, 1 hit
PfamiView protein in Pfam
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00867 DNAPOLG
SMARTiView protein in SMART
SM00482 POLAc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOG_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12704
Secondary accession number(s): Q96WV3, Q9P7I4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 5, 2002
Last modified: December 5, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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