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Protein

Sodium transport ATPase 5

Gene

ENA5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance.By similarity

Miscellaneous

Present with 606 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + H2O + Na+(In) = ADP + phosphate + Na+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3694-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Sodium transport, Transport
LigandATP-binding, Magnesium, Nucleotide-binding, Sodium

Enzyme and pathway databases

BioCyciYEAST:G3O-29652-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium transport ATPase 5 (EC:3.6.3.7)
Gene namesi
Name:ENA5
Ordered Locus Names:YDR038C
ORF Names:YD9673.10c
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR038C
SGDiS000002445 ENA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 90ExtracellularSequence analysis6
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 282CytoplasmicSequence analysisAdd BLAST171
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 312ExtracellularSequence analysis9
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 815CytoplasmicSequence analysisAdd BLAST482
Transmembranei816 – 836HelicalSequence analysisAdd BLAST21
Topological domaini837 – 848ExtracellularSequence analysisAdd BLAST12
Transmembranei849 – 869HelicalSequence analysisAdd BLAST21
Topological domaini870 – 885CytoplasmicSequence analysisAdd BLAST16
Transmembranei886 – 906HelicalSequence analysisAdd BLAST21
Topological domaini907 – 943ExtracellularSequence analysisAdd BLAST37
Transmembranei944 – 964HelicalSequence analysisAdd BLAST21
Topological domaini965 – 991CytoplasmicSequence analysisAdd BLAST27
Transmembranei992 – 1012HelicalSequence analysisAdd BLAST21
Topological domaini1013 – 1021ExtracellularSequence analysis9
Transmembranei1022 – 1042HelicalSequence analysisAdd BLAST21
Topological domaini1043 – 1091CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462441 – 1091Sodium transport ATPase 5Add BLAST1091

Proteomic databases

MaxQBiQ12691
PaxDbiQ12691
PRIDEiQ12691

PTM databases

iPTMnetiQ12691

Interactioni

Protein-protein interaction databases

BioGridi32093, 32 interactors
DIPiDIP-5253N
IntActiQ12691, 3 interactors
MINTiQ12691
STRINGi4932.YDR038C

Structurei

3D structure databases

ProteinModelPortaliQ12691
SMRiQ12691
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000144699
HOGENOMiHOG000265621
InParanoidiQ12691
KOiK01536
OMAiKAWIPSK
OrthoDBiEOG092C0DMA

Family and domain databases

CDDicd02086 P-type_ATPase_Na_ENA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006414 P-type_ATPase_IID
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01523 ATPase-IID_K-Na, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q12691-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEGTVKENN NEEFNAYHTL TTEEAAEFIG TSLTEGLTQD ESLRRLKAVG
60 70 80 90 100
ENTLGDDTKI DYKAMVLHQV CNAMIMVLVI SMAISFAVRD WITGGVISFV
110 120 130 140 150
IAVNVLIGLV QEYKATKTMN SLKNLSSPNA HVIRNGKSET INSKDVVPGD
160 170 180 190 200
ICLVKVGDTI PADLRLIETK NFDTDESLLT GESLPVSKDA NLVFGKEEET
210 220 230 240 250
SVGDRLNLAF SSSAVVKGRA KGIVIKTALN SEIGKIAKSL QGDSGLISRD
260 270 280 290 300
PSKSWLQNTW ISTKKVTGAF LGTNVGTPLH RKLSKLAVLL FWIAVLFAII
310 320 330 340 350
VMASQKFDVD KRVAIYAICV ALSMIPSSLV VVLTITMSVG AAVMVSRNVI
360 370 380 390 400
VRKLDSLEAL GAVNDICSDK TGTLTQGKML ARQIWIPRFG TITISNSDDP
410 420 430 440 450
FNPNEGNVSL IPRFSPYEYS HNEDGDVGIL QNFKDRLYEK DLPEDIDMDL
460 470 480 490 500
FQKWLETATL ANIATVFKDD ATDCWKAHGD PTEIAIQVFA TKMDLPHNAL
510 520 530 540 550
TGEKSTNQSN ENDQSSLSQH NEKPGSAQFE HIAEFPFDST VKRMSSVYYN
560 570 580 590 600
NHNETYNIYG KGAFESIISC CSSWYGKDGV KITPLTDCDV ETIRKNVYSL
610 620 630 640 650
SNEGLRVLGF ASKSFTKDQV NDDQLKNITS NRATAESDLV FLGLIGIYDP
660 670 680 690 700
PRNETAGAVK KFHQAGINVH MLTGDFVGTA KAIAQEVGIL PTNLYHYSQE
710 720 730 740 750
IVDSMVMTGS QFDGLSEEEV DDLPVLPLVI ARCSPQTKVR MIEALHRRKK
760 770 780 790 800
FCAMTGDGVN DSPSLKMANV GIAMGINGSD VSKEASDIVL SDDNFASILN
810 820 830 840 850
AVEEGRRMTD NIQKFVLQLL AENVAQALYL IIGLVFRDEN GKSVFPLSPV
860 870 880 890 900
EVLWIIVVTS CFPAMGLGLE KAAPDLMDRP PNDSEVGIFT WEVIIDTFAY
910 920 930 940 950
GIIMTGSCMA SFTGSLYGIN SGRLGHDCDG TYNSSCRDVY RSRSAAFATM
960 970 980 990 1000
TWCALILAWE VVDMRRSFFR MHPDTDSPVK EFFRSIWGNQ FLFWSIIFGF
1010 1020 1030 1040 1050
VSAFPVVYIP VINDKVFLHK PIGAEWGLAI AFTIAFWIGA ELYKCGKRRY
1060 1070 1080 1090
FKTQRAHNSE NDLERSSKHD PFEAYSTSTT LQSEINISVK H
Length:1,091
Mass (Da):120,296
Last modified:November 1, 1996 - v1
Checksum:i66CEF9D7FE2549F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68196 Genomic DNA Translation: CAA92377.1
Z74334 Genomic DNA Translation: CAA98864.1
Z74335 Genomic DNA Translation: CAA98865.1
BK006938 Genomic DNA Translation: DAA11886.1
PIRiS67852
RefSeqiNP_010323.3, NM_001180346.3

Genome annotation databases

EnsemblFungiiYDR038C; YDR038C; YDR038C
GeneIDi851608
KEGGisce:YDR038C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68196 Genomic DNA Translation: CAA92377.1
Z74334 Genomic DNA Translation: CAA98864.1
Z74335 Genomic DNA Translation: CAA98865.1
BK006938 Genomic DNA Translation: DAA11886.1
PIRiS67852
RefSeqiNP_010323.3, NM_001180346.3

3D structure databases

ProteinModelPortaliQ12691
SMRiQ12691
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32093, 32 interactors
DIPiDIP-5253N
IntActiQ12691, 3 interactors
MINTiQ12691
STRINGi4932.YDR038C

PTM databases

iPTMnetiQ12691

Proteomic databases

MaxQBiQ12691
PaxDbiQ12691
PRIDEiQ12691

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR038C; YDR038C; YDR038C
GeneIDi851608
KEGGisce:YDR038C

Organism-specific databases

EuPathDBiFungiDB:YDR038C
SGDiS000002445 ENA5

Phylogenomic databases

GeneTreeiENSGT00910000144699
HOGENOMiHOG000265621
InParanoidiQ12691
KOiK01536
OMAiKAWIPSK
OrthoDBiEOG092C0DMA

Enzyme and pathway databases

BioCyciYEAST:G3O-29652-MONOMER

Miscellaneous databases

PROiPR:Q12691

Family and domain databases

CDDicd02086 P-type_ATPase_Na_ENA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006414 P-type_ATPase_IID
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01523 ATPase-IID_K-Na, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATN5_YEAST
AccessioniPrimary (citable) accession number: Q12691
Secondary accession number(s): D6VS26, E9PAF4, P89901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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