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UniProtKB - Q12500 (AVL9_YEAST)

Entry version 134 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Late secretory pathway protein AVL9

Gene

AVL9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in the late secretory pathway. Required for the generation of secretory vesicles as well as for actin polarization and polarized growth.1 Publication

Miscellaneous

Present with 7500 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • post-Golgi vesicle-mediated transport Source: SGD
Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Late secretory pathway protein AVL9
Alternative name(s):
APL2 VPS1 synthetic lethal protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AVL9
Ordered Locus Names:YLR114C
ORF Names:L2941
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000004104, AVL9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YLR114C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002474241 – 764Late secretory pathway protein AVL9Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei519PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q12500

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12500

PRoteomics IDEntifications database

More...PRIDEi		Q12500

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q12500

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12500

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		31386, 257 interactors

Database of interacting proteins

More...DIPi		DIP-4819N

Protein interaction database and analysis system

More...IntActi		Q12500, 1 interactor

STRING: functional protein association networks

More...STRINGi		4932.YLR114C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12500, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 173uDENNPROSITE-ProRule annotationAdd BLAST164
Domaini195 – 360cDENNPROSITE-ProRule annotationAdd BLAST166
Domaini362 – 464dDENNPROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi603 – 682Asp-richAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AVL9 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3823, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010255

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009066_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12500

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018307, ABL9/DENND6_dom
IPR037516, Tripartite_DENN

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09794, Avl9, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50211, DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12500-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEHEEAVIF GICLVDFHHK RGPEIEYWYG LPEGTQSAEL WPNLPFQALP 
        60         70         80         90        100
DGSHSFEETF TYFTLLYDER RQRSPPNGAT DLSDDSINDN TTLFAISCSR 
       110        120        130        140        150
QIKSDELVTK DKDVTRSTVQ KAIVVISRQP IFGQIKDKLS IVTNAFFLQH 
       160        170        180        190        200
DFGDRKIIQS LYENLKSIYT PASLVRNAEN RLYIGLCLRK ILHDFKRNAL 
       210        220        230        240        250
VLLKAIMLEK KIIVYGNDVE ALCNLQFGLI SLIPDLMSNL QDSGSPQLFQ 
       260        270        280        290        300
DISKLNVVDS FKSSNRESVL RFLGFPLPIF EKGGLFSPYT PLQQMNDIRS 
       310        320        330        340        350
ERTLFFMIGS SNTLLAEQKE ELCHIFVNTD NSTVDILDKT LNPVLQLSSH 
       360        370        380        390        400
DKKWIESISG IVSDTWNEND DETPKNSQFE GSEDFIRWQF EDYLTGLLSS 
       410        420        430        440        450
VKLSDYLDLH KENDQALKTI PEDMLNSNPV HLFNLNWVQS WKETQNFLIF 
       460        470        480        490        500
NSRTDDRLFD LFPPKHIYNG ADTLSLLQQR FLATFHNLKR SSSNSSSNKN 
       510        520        530        540        550
GHQSEEDIKD QESIESKKSV SQISVNPGKN TDKPAANLWN SWKEYFNKPK 
       560        570        580        590        600
NTANEDVTES TEDLKNRSKT SNAIQKAMMG LGLHYKPDAE TDQQSEEVGN 
       610        620        630        640        650
SEDNEDDDTD EDSEDDDDDG GDDDDSEDDD DDDDGEGDEN GDDGEGDENG 
       660        670        680        690        700
DDGEGDENGD KEDSQDFSNG FTDVTNINTD HDKENEQNFE GNAENFNEDE 
       710        720        730        740        750
TVADKDIEGG PESNKNSDSK TDIYENDRNV EDSSKTRNTV KKSNEEGGAN 
       760 
DAAIGNCVQD EEKL
Length:764
Mass (Da):86,426
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i159A00CF933A5C4A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X89514 Genomic DNA Translation: CAA61692.1
U53878 Genomic DNA Translation: AAB67559.1
Z73286 Genomic DNA Translation: CAA97681.1
BK006945 Genomic DNA Translation: DAA09428.1

Protein sequence database of the Protein Information Resource

More...PIRi		S64951

NCBI Reference Sequences

More...RefSeqi		NP_013215.1, NM_001182001.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YLR114C_mRNA; YLR114C; YLR114C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		850805

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YLR114C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89514 Genomic DNA Translation: CAA61692.1
U53878 Genomic DNA Translation: AAB67559.1
Z73286 Genomic DNA Translation: CAA97681.1
BK006945 Genomic DNA Translation: DAA09428.1
PIRiS64951
RefSeqiNP_013215.1, NM_001182001.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31386, 257 interactors
DIPiDIP-4819N
IntActiQ12500, 1 interactor
STRINGi4932.YLR114C

PTM databases

CarbonylDBiQ12500
iPTMnetiQ12500

Proteomic databases

MaxQBiQ12500
PaxDbiQ12500
PRIDEiQ12500

Genome annotation databases

EnsemblFungiiYLR114C_mRNA; YLR114C; YLR114C
GeneIDi850805
KEGGisce:YLR114C

Organism-specific databases

SGDiS000004104, AVL9
VEuPathDBiFungiDB:YLR114C

Phylogenomic databases

eggNOGiKOG3823, Eukaryota
GeneTreeiENSGT00390000010255
HOGENOMiCLU_009066_3_0_1
InParanoidiQ12500

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q12500
RNActiQ12500, protein

Family and domain databases

InterProiView protein in InterPro
IPR018307, ABL9/DENND6_dom
IPR037516, Tripartite_DENN
PfamiView protein in Pfam
PF09794, Avl9, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAVL9_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12500
Secondary accession number(s): D6VYB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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