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Protein

Nucleolar protein 58

Gene

NOP58

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for pre-18S rRNA processing. May bind microtubules.2 Publications

Miscellaneous

Present with 34700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • snoRNA binding Source: GO_Central
  • snRNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33793-MONOMER
ReactomeiR-SCE-4570464 SUMOylation of RNA binding proteins
R-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 58
Alternative name(s):
Nucleolar protein 5
Gene namesi
Name:NOP58
Synonyms:NOP5
Ordered Locus Names:YOR310C
ORF Names:O6108
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR310C
SGDiS000005837 NOP58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190291 – 511Nucleolar protein 58Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ12499
PaxDbiQ12499
PRIDEiQ12499

PTM databases

iPTMnetiQ12499

Interactioni

Subunit structurei

Interacts with SIK1/NOP56 and NOP1. Interacts with the trimethylguanosine synthase TGS1. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34698, 290 interactors
ComplexPortaliCPX-1604 Small ribosomal subunit processome, variant 1
CPX-1607 Small ribosomal subunit processome, variant 2
CPX-1608 Small ribosomal subunit processome, variant 3
CPX-729 Box C/D snoRNP complex
DIPiDIP-5843N
IntActiQ12499, 86 interactors
MINTiQ12499
STRINGi4932.YOR310C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WLCelectron microscopy3.80SB133-511[»]
5WYJelectron microscopy8.703E1-511[»]
5WYKelectron microscopy4.503E1-511[»]
ProteinModelPortaliQ12499
SMRiQ12499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 403NopPROSITE-ProRule annotationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili435 – 511Sequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi441 – 511Asp/Glu/Lys-richAdd BLAST71

Sequence similaritiesi

Belongs to the NOP5/NOP56 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00550000074998
HOGENOMiHOG000196310
InParanoidiQ12499
KOiK14565
OMAiTEKYEHK
OrthoDBiEOG092C3GG0

Family and domain databases

Gene3Di1.10.287.660, 2 hits
InterProiView protein in InterPro
IPR029012 Helix_hairpin_bin_sf
IPR012974 NOP5_N
IPR002687 Nop_dom
IPR036070 Nop_dom_sf
IPR012976 NOSIC
PfamiView protein in Pfam
PF01798 Nop, 1 hit
PF08156 NOP5NT, 1 hit
SMARTiView protein in SMART
SM00931 NOSIC, 1 hit
SUPFAMiSSF89124 SSF89124, 1 hit
PROSITEiView protein in PROSITE
PS51358 NOP, 1 hit

Sequencei

Sequence statusi: Complete.

Q12499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVLTETSA GYALLKASDK KIYKSSSLIQ DLDSSDKVLK EFKIAAFSKF
60 70 80 90 100
NSAANALEEA NSIIEGKVSS QLEKLLEEIK KDKKSTLIVS ETKLANAINK
110 120 130 140 150
LGLNFNVVSD AVTLDIYRAI KEYLPELLPG MSDNDLSKMS LGLAHSIGRH
160 170 180 190 200
KLKFSADKVD VMIIQAIALL DDLDKELNTY AMRCKEWYGW HFPELAKIVT
210 220 230 240 250
DSVAYARIIL TMGIRSKASE TDLSEILPEE IEERVKTAAE VSMGTEITQT
260 270 280 290 300
DLDNINALAE QIVEFAAYRE QLSNYLSARM KAIAPNLTQL VGELVGARLI
310 320 330 340 350
AHSGSLISLA KSPASTIQIL GAEKALFRAL KTKHDTPKYG LLYHASLVGQ
360 370 380 390 400
ATGKNKGKIA RVLAAKAAVS LRYDALAEDR DDSGDIGLES RAKVENRLSQ
410 420 430 440 450
LEGRDLRTTP KVVREAKKVE MTEARAYNAD ADTAKAASDS ESDSDDEEEE
460 470 480 490 500
KKEKKEKKRK RDDDEDSKDS KKAKKEKKDK KEKKEKKEKK EKKEKKEKKE
510
KKSKKEKKEK K
Length:511
Mass (Da):56,956
Last modified:November 1, 1996 - v1
Checksum:i8A2889448B2A19E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056070 Genomic DNA Translation: AAC39484.1
X90565 Genomic DNA Translation: CAA62165.1
Z75217 Genomic DNA Translation: CAA99630.1
BK006948 Genomic DNA Translation: DAA11075.1
PIRiS58322
RefSeqiNP_014955.1, NM_001183730.1

Genome annotation databases

EnsemblFungiiYOR310C; YOR310C; YOR310C
GeneIDi854487
KEGGisce:YOR310C

Similar proteinsi

Entry informationi

Entry nameiNOP58_YEAST
AccessioniPrimary (citable) accession number: Q12499
Secondary accession number(s): D6W309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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