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Entry version 149 (11 Dec 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Inositol hexakisphosphate kinase 1

Gene

KCS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance.7 Publications

Miscellaneous

Present with 1940 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.3 µM for InsP61 Publication
  2. KM=1.2 µM for InsP51 Publication
  1. Vmax=2 µmol/min/mg enzyme1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29635-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-1855167 Synthesis of pyrophosphates in the cytosol
R-SCE-1855191 Synthesis of IPs in the nucleus

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q12494

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
InsP6 kinase KCS1
PKC1 suppressor protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCS1
Ordered Locus Names:YDR017C
ORF Names:PZF1050
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YDR017C

Saccharomyces Genome Database

More...
SGDi
S000002424 KCS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002559551 – 1050Inositol hexakisphosphate kinase 1Add BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei150PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12494

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12494

PRoteomics IDEntifications database

More...
PRIDEi
Q12494

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12494

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32067, 282 interactors

Database of interacting proteins

More...
DIPi
DIP-1402N

Protein interaction database and analysis system

More...
IntActi
Q12494, 6 interactors

Molecular INTeraction database

More...
MINTi
Q12494

STRING: functional protein association networks

More...
STRINGi
4932.YDR017C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12494 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12494

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni772 – 780Substrate bindingBy similarity9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001029

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12494

KEGG Orthology (KO)

More...
KOi
K07756

Identification of Orthologs from Complete Genome Data

More...
OMAi
QIERYIV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.510.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12400 PTHR12400, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03770 IPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12494-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSHEIHDK IPDTLREQQQ HLRQKESEGC ITTLKDLNVP ETKKLSSVLH
60 70 80 90 100
GRKASTYLRI FRDDECLADN NNGVDSNNGG SVTCADKITR SEATPKSVPE
110 120 130 140 150
GLQVSEKKNN PDTLSSSLSS FILSNHEEPA IKPNKHVAHR NNITETGQGS
160 170 180 190 200
GEDIAKQQSH QPQVLHHQTS LKPIQNVDEG CISPKSTYQE SLHGISEDLT
210 220 230 240 250
LKPVSSATYY PHKSKADSGY EEKDKMENDI DTIQPATINC ASGIATLPSS
260 270 280 290 300
YNRHTFKVKT YSTLSQSLRQ ENVNNRSNEK KPQQFVPHSE SIKEKPNTFE
310 320 330 340 350
QDKEGEQADE EEDEGDNEHR EYPLAVELKP FTNRVGGHTA IFRFSKRAVC
360 370 380 390 400
KALVNRENRW YENIELCHKE LLQFMPRYIG VLNVRQHFQS KDDFLSDLDQ
410 420 430 440 450
ENNGKNDTSN ENKDIEVNHN NNDDIALNTE PTGTPLTHIH SFPLEHSSRQ
460 470 480 490 500
VLEKEHPEIE SVHPHVKRSL SSSNQPSLLP EVVLNDNRHI IPESLWYKYS
510 520 530 540 550
DSPNSAPNDS YFSSSSSHNS CSFGERGNTN KLKRRDSGST MINTELKNLV
560 570 580 590 600
IREVFAPKCF RRKRNSNTTT MGNHNARLGS SPSFLTQKSR ASSHDASNTS
610 620 630 640 650
MKTLGDSSSQ ASLQMDDSKV NPNLQDPFLK KSLHEKISNA LDGSHSVMDL
660 670 680 690 700
KQFHKNEQIK HKNSFCNSLS PILTATNSRD DGEFATSPNY ISNAQDGVFD
710 720 730 740 750
MDEDTGNETI NMDNHGCHLD SGKNMIIKSL AYNVSNDYSH HDIESITFEE
760 770 780 790 800
TSHTIVSKFI LLEDLTRNMN KPCALDLKMG TRQYGVDAKR AKQLSQRAKC
810 820 830 840 850
LKTTSRRLGV RICGLKVWNK DYYITRDKYF GRRVKVGWQF ARVLARFLYD
860 870 880 890 900
GKTIESLIRQ IPRLIKQLDT LYSEIFNLKG YRLYGASLLL MYDGDANKSN
910 920 930 940 950
SKRKKAANVK VNLIDFARCV TKEDAMECMD KFRIPPKSPN IEDKGFLRGV
960 970 980 990 1000
KSLRFYLLLI WNYLTSDMPL IFDEVEMNDM ISEEADSNSF TSATGSKINF
1010 1020 1030 1040 1050
NSKWDWLDEF DKEDEEMYND PNSKLRQKWR KYELIFDAEP RYNDDAQVSD
Length:1,050
Mass (Da):119,550
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C7507CA5F4B0FC7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S81651 Genomic DNA Translation: AAB36234.1
X95966 Genomic DNA Translation: CAA65208.1
Z49770 Genomic DNA Translation: CAA89842.1
Z74313 Genomic DNA Translation: CAA98837.1
Z74314 Genomic DNA Translation: CAA98839.1
BK006938 Genomic DNA Translation: DAA11863.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54640

NCBI Reference Sequences

More...
RefSeqi
NP_010300.3, NM_001180325.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR017C_mRNA; YDR017C; YDR017C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR017C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81651 Genomic DNA Translation: AAB36234.1
X95966 Genomic DNA Translation: CAA65208.1
Z49770 Genomic DNA Translation: CAA89842.1
Z74313 Genomic DNA Translation: CAA98837.1
Z74314 Genomic DNA Translation: CAA98839.1
BK006938 Genomic DNA Translation: DAA11863.1
PIRiS54640
RefSeqiNP_010300.3, NM_001180325.3

3D structure databases

SMRiQ12494
ModBaseiSearch...

Protein-protein interaction databases

BioGridi32067, 282 interactors
DIPiDIP-1402N
IntActiQ12494, 6 interactors
MINTiQ12494
STRINGi4932.YDR017C

PTM databases

iPTMnetiQ12494

Proteomic databases

MaxQBiQ12494
PaxDbiQ12494
PRIDEiQ12494

Genome annotation databases

EnsemblFungiiYDR017C_mRNA; YDR017C; YDR017C
GeneIDi851580
KEGGisce:YDR017C

Organism-specific databases

EuPathDBiFungiDB:YDR017C
SGDiS000002424 KCS1

Phylogenomic databases

HOGENOMiHOG000001029
InParanoidiQ12494
KOiK07756
OMAiQIERYIV

Enzyme and pathway databases

BioCyciYEAST:G3O-29635-MONOMER
ReactomeiR-SCE-1855167 Synthesis of pyrophosphates in the cytosol
R-SCE-1855191 Synthesis of IPs in the nucleus
SABIO-RKiQ12494

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12494
RNActiQ12494 protein

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCS1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12494
Secondary accession number(s): D6VS03, P89899, Q7LGR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: December 11, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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