We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q12482 (AGC1_YEAST)
Protein
Mitochondrial aspartate-glutamate transporter AGC1
Gene
AGC1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.
2 PublicationsGO - Molecular functioni
- antiporter activity Source: SGD
- L-aspartate transmembrane transporter activity Source: SGD
- L-glutamate transmembrane transporter activity Source: SGD
- transmembrane transporter activity Source: GO_Central
- uniporter activity Source: SGD
GO - Biological processi
- aspartate transmembrane transport Source: SGD
- cellular nitrogen compound biosynthetic process Source: SGD
- L-glutamate transmembrane transport Source: SGD
- malate-aspartate shuttle Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-SCE-70263, Gluconeogenesis R-SCE-8963693, Aspartate and asparagine metabolism |
Protein family/group databases
TCDBi | 2.A.29.14.4, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial aspartate-glutamate transporter AGC1Alternative name(s): Aspartate-glutamate carrier 1 |
Gene namesi | Name:AGC1 Ordered Locus Names:YPR021C ORF Names:YP9367.01C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006225, AGC1 |
VEuPathDBi | FungiDB:YPR021C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Multi-pass membrane protein 2 Publications
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- vacuole-mitochondrion membrane contact site Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 534 – 554 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 591 – 611 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 622 – 642 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 681 – 702 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Transmembranei | 731 – 751 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 786 – 806 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227601 | 1 – 902 | Mitochondrial aspartate-glutamate transporter AGC1Add BLAST | 902 |
Proteomic databases
MaxQBi | Q12482 |
PaxDbi | Q12482 |
PRIDEi | Q12482 |
PTM databases
iPTMneti | Q12482 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36198, 109 interactors |
DIPi | DIP-8968N |
STRINGi | 4932.YPR021C |
Miscellaneous databases
RNActi | Q12482, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 528 – 614 | Solcar 1Add BLAST | 87 | |
Repeati | 622 – 710 | Solcar 2Add BLAST | 89 | |
Repeati | 725 – 813 | Solcar 3Add BLAST | 89 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0751, Eukaryota |
HOGENOMi | CLU_014931_1_0_1 |
InParanoidi | Q12482 |
OMAi | YYYKSCQ |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q12482-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQINSNSRK KKQQLEVFKY FASVLTKEDK PISISNGMLD MPTVNSSKLT
60 70 80 90 100
AGNGKPDTEK LTGELILTYD DFIELISSSK TIYSKFTDHS FNLNQIPKNV
110 120 130 140 150
FGCIFFAIDE QNKGYLTLND WFYFNNLLEY DNYHLIILYE FFRKFDVENL
160 170 180 190 200
KAKQKKELGS SSFNLKAADD RIKSINYGNR FLSFDDLLLN LNQFKDTIRL
210 220 230 240 250
LHESIDDNFV KDNKLLLDWN DFRFLKFYKC YHENEEYLSL NSLVTILQND
260 270 280 290 300
LKNEKIFIGF DRLAQMDSQG HRLALSKNQL TYLLRLFYSH RVSADIFSSL
310 320 330 340 350
NLSNTELLKA DNNSIPYNVF KDIFYLFQNF DLLNQIFHKY VTENNLNEQD
360 370 380 390 400
IREQIVTKND FMTVLNAQYN KVNNIIEFSP SQINLLFSIV ANSKENRRLR
410 420 430 440 450
KRNQDRDDEL LNDHHYDSDI DFFIHNEYLH GVSRSRKNLE SFNDYYHDLS
460 470 480 490 500
DGFDQDSGVK KASKASTGLF ESVFGGKKDK ATMRSDLTIE DFMKILNPNY
510 520 530 540 550
LNDLVHQMEL QKNQNESLYI NYYFYPIFDS LYNFSLGSIA GCIGATVVYP
560 570 580 590 600
IDFIKTRMQA QRSLAQYKNS IDCLLKIISR EGIKGLYSGL GPQLIGVAPE
610 620 630 640 650
KAIKLTVNDF MRNRLTDKNG KLSLFPEIIS GASAGACQVI FTNPLEIVKI
660 670 680 690 700
RLQVQSDYVG ENIQQANETA TQIVKKLGLR GLYNGVAACL MRDVPFSAIY
710 720 730 740 750
FPTYAHLKKD LFDFDPNDKT KRNRLKTWEL LTAGAIAGMP AAFLTTPFDV
760 770 780 790 800
IKTRLQIDPR KGETKYNGIF HAIRTILKEE SFRSFFKGGG ARVLRSSPQF
810 820 830 840 850
GFTLAAYELF KGFIPSPDNK LKSREGRKRF CIDDDAGNEE TVVHSNGELP
860 870 880 890 900
QQKFYSDDRK HANYYYKSCQ IAKTFIDLDN NFSRFDSSVY KNFQEHLRSI
NG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71255 Genomic DNA Translation: CAA95017.1 Z49274 Genomic DNA Translation: CAA89275.1 BK006949 Genomic DNA Translation: DAA11447.1 |
PIRi | S54495 |
RefSeqi | NP_015346.1, NM_001184118.1 |
Genome annotation databases
EnsemblFungii | YPR021C_mRNA; YPR021C; YPR021C |
GeneIDi | 856132 |
KEGGi | sce:YPR021C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71255 Genomic DNA Translation: CAA95017.1 Z49274 Genomic DNA Translation: CAA89275.1 BK006949 Genomic DNA Translation: DAA11447.1 |
PIRi | S54495 |
RefSeqi | NP_015346.1, NM_001184118.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36198, 109 interactors |
DIPi | DIP-8968N |
STRINGi | 4932.YPR021C |
Protein family/group databases
TCDBi | 2.A.29.14.4, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q12482 |
Proteomic databases
MaxQBi | Q12482 |
PaxDbi | Q12482 |
PRIDEi | Q12482 |
Genome annotation databases
EnsemblFungii | YPR021C_mRNA; YPR021C; YPR021C |
GeneIDi | 856132 |
KEGGi | sce:YPR021C |
Organism-specific databases
SGDi | S000006225, AGC1 |
VEuPathDBi | FungiDB:YPR021C |
Phylogenomic databases
eggNOGi | KOG0751, Eukaryota |
HOGENOMi | CLU_014931_1_0_1 |
InParanoidi | Q12482 |
OMAi | YYYKSCQ |
Enzyme and pathway databases
Reactomei | R-SCE-70263, Gluconeogenesis R-SCE-8963693, Aspartate and asparagine metabolism |
Miscellaneous databases
PROi | PR:Q12482 |
RNActi | Q12482, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | AGC1_YEAST | |
Accessioni | Q12482Primary (citable) accession number: Q12482 Secondary accession number(s): D6W431 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families