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UniProtKB - Q12482 (AGC1_YEAST)

Entry version 160 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Mitochondrial aspartate-glutamate transporter AGC1

Gene

AGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport
LigandCalcium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		YEAST:G3O-34181-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-428643, Organic anion transporters
R-SCE-70263, Gluconeogenesis
R-SCE-8963693, Aspartate and asparagine metabolism

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.29.14.4, the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial aspartate-glutamate transporter AGC1
Alternative name(s):
Aspartate-glutamate carrier 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGC1
Ordered Locus Names:YPR021C
ORF Names:YP9367.01C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:YPR021C

Saccharomyces Genome Database

More...SGDi		S000006225, AGC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei534 – 554Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei591 – 611Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei622 – 642Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei681 – 702Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei731 – 751Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei786 – 806Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002276011 – 902Mitochondrial aspartate-glutamate transporter AGC1Add BLAST902

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q12482

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12482

PRoteomics IDEntifications database

More...PRIDEi		Q12482

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12482

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		36198, 105 interactors

Database of interacting proteins

More...DIPi		DIP-8968N

STRING: functional protein association networks

More...STRINGi		4932.YPR021C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12482, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12482

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati528 – 614Solcar 1Add BLAST87
Repeati622 – 710Solcar 2Add BLAST89
Repeati725 – 813Solcar 3Add BLAST89

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0751, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014931_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12482

KEGG Orthology (KO)

More...KOi		K15105

Identification of Orthologs from Complete Genome Data

More...OMAi		YYYKSCQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00153, Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00926, MITOCARRIER

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103506, SSF103506, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50920, SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12482-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQINSNSRK KKQQLEVFKY FASVLTKEDK PISISNGMLD MPTVNSSKLT 
        60         70         80         90        100
AGNGKPDTEK LTGELILTYD DFIELISSSK TIYSKFTDHS FNLNQIPKNV 
       110        120        130        140        150
FGCIFFAIDE QNKGYLTLND WFYFNNLLEY DNYHLIILYE FFRKFDVENL 
       160        170        180        190        200
KAKQKKELGS SSFNLKAADD RIKSINYGNR FLSFDDLLLN LNQFKDTIRL 
       210        220        230        240        250
LHESIDDNFV KDNKLLLDWN DFRFLKFYKC YHENEEYLSL NSLVTILQND 
       260        270        280        290        300
LKNEKIFIGF DRLAQMDSQG HRLALSKNQL TYLLRLFYSH RVSADIFSSL 
       310        320        330        340        350
NLSNTELLKA DNNSIPYNVF KDIFYLFQNF DLLNQIFHKY VTENNLNEQD 
       360        370        380        390        400
IREQIVTKND FMTVLNAQYN KVNNIIEFSP SQINLLFSIV ANSKENRRLR 
       410        420        430        440        450
KRNQDRDDEL LNDHHYDSDI DFFIHNEYLH GVSRSRKNLE SFNDYYHDLS 
       460        470        480        490        500
DGFDQDSGVK KASKASTGLF ESVFGGKKDK ATMRSDLTIE DFMKILNPNY 
       510        520        530        540        550
LNDLVHQMEL QKNQNESLYI NYYFYPIFDS LYNFSLGSIA GCIGATVVYP 
       560        570        580        590        600
IDFIKTRMQA QRSLAQYKNS IDCLLKIISR EGIKGLYSGL GPQLIGVAPE 
       610        620        630        640        650
KAIKLTVNDF MRNRLTDKNG KLSLFPEIIS GASAGACQVI FTNPLEIVKI 
       660        670        680        690        700
RLQVQSDYVG ENIQQANETA TQIVKKLGLR GLYNGVAACL MRDVPFSAIY 
       710        720        730        740        750
FPTYAHLKKD LFDFDPNDKT KRNRLKTWEL LTAGAIAGMP AAFLTTPFDV 
       760        770        780        790        800
IKTRLQIDPR KGETKYNGIF HAIRTILKEE SFRSFFKGGG ARVLRSSPQF 
       810        820        830        840        850
GFTLAAYELF KGFIPSPDNK LKSREGRKRF CIDDDAGNEE TVVHSNGELP 
       860        870        880        890        900
QQKFYSDDRK HANYYYKSCQ IAKTFIDLDN NFSRFDSSVY KNFQEHLRSI 

NG
Length:902
Mass (Da):104,304
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07D6F831E2CD15CF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95017.1
Z49274 Genomic DNA Translation: CAA89275.1
BK006949 Genomic DNA Translation: DAA11447.1

Protein sequence database of the Protein Information Resource

More...PIRi		S54495

NCBI Reference Sequences

More...RefSeqi		NP_015346.1, NM_001184118.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YPR021C_mRNA; YPR021C; YPR021C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		856132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YPR021C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95017.1
Z49274 Genomic DNA Translation: CAA89275.1
BK006949 Genomic DNA Translation: DAA11447.1
PIRiS54495
RefSeqiNP_015346.1, NM_001184118.1

3D structure databases

SMRiQ12482
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36198, 105 interactors
DIPiDIP-8968N
STRINGi4932.YPR021C

Protein family/group databases

TCDBi2.A.29.14.4, the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ12482

Proteomic databases

MaxQBiQ12482
PaxDbiQ12482
PRIDEiQ12482

Genome annotation databases

EnsemblFungiiYPR021C_mRNA; YPR021C; YPR021C
GeneIDi856132
KEGGisce:YPR021C

Organism-specific databases

EuPathDBiFungiDB:YPR021C
SGDiS000006225, AGC1

Phylogenomic databases

eggNOGiKOG0751, Eukaryota
HOGENOMiCLU_014931_1_0_1
InParanoidiQ12482
KOiK15105
OMAiYYYKSCQ

Enzyme and pathway databases

BioCyciYEAST:G3O-34181-MONOMER
ReactomeiR-SCE-428643, Organic anion transporters
R-SCE-70263, Gluconeogenesis
R-SCE-8963693, Aspartate and asparagine metabolism

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q12482
RNActiQ12482, protein

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153, Mito_carr, 3 hits
PRINTSiPR00926, MITOCARRIER
SUPFAMiSSF103506, SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920, SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGC1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12482
Secondary accession number(s): D6W431
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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