Mitochondrial aspartate-glutamate transporter AGC1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• antiporter activity Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.4

    "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae."
    Cavero S., Vozza A., del Arco A., Palmieri L., Villa A., Blanco E., Runswick M.J., Walker J.E., Cerdan S., Palmieri F., Satrustegui J.
    Mol. Microbiol. 50:1257-1269(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• L-aspartate transmembrane transporter activity Source: SGDInferred from direct assayⁱ
  • Ref.4

    "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae."
    Cavero S., Vozza A., del Arco A., Palmieri L., Villa A., Blanco E., Runswick M.J., Walker J.E., Cerdan S., Palmieri F., Satrustegui J.
    Mol. Microbiol. 50:1257-1269(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• L-glutamate transmembrane transporter activity Source: SGDInferred from direct assayⁱ
  • Ref.4

    "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae."
    Cavero S., Vozza A., del Arco A., Palmieri L., Villa A., Blanco E., Runswick M.J., Walker J.E., Cerdan S., Palmieri F., Satrustegui J.
    Mol. Microbiol. 50:1257-1269(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• uniporter activity Source: SGDInferred from direct assayⁱ
  • Ref.4

    "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae."
    Cavero S., Vozza A., del Arco A., Palmieri L., Villa A., Blanco E., Runswick M.J., Walker J.E., Cerdan S., Palmieri F., Satrustegui J.
    Mol. Microbiol. 50:1257-1269(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.

GO - Biological processⁱ

• aspartate transmembrane transport Source: SGDInferred from direct assayⁱ
  • Ref.4

    "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae."
    Cavero S., Vozza A., del Arco A., Palmieri L., Villa A., Blanco E., Runswick M.J., Walker J.E., Cerdan S., Palmieri F., Satrustegui J.
    Mol. Microbiol. 50:1257-1269(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• cellular nitrogen compound biosynthetic process Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.4

    "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae."
    Cavero S., Vozza A., del Arco A., Palmieri L., Villa A., Blanco E., Runswick M.J., Walker J.E., Cerdan S., Palmieri F., Satrustegui J.
    Mol. Microbiol. 50:1257-1269(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• L-glutamate transmembrane transport Source: SGDInferred from direct assayⁱ
  • Ref.4

    "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae."
    Cavero S., Vozza A., del Arco A., Palmieri L., Villa A., Blanco E., Runswick M.J., Walker J.E., Cerdan S., Palmieri F., Satrustegui J.
    Mol. Microbiol. 50:1257-1269(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• malate-aspartate shuttle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEQINSNSRK KKQQLEVFKY FASVLTKEDK PISISNGMLD MPTVNSSKLT 
        60         70         80         90        100
AGNGKPDTEK LTGELILTYD DFIELISSSK TIYSKFTDHS FNLNQIPKNV 
       110        120        130        140        150
FGCIFFAIDE QNKGYLTLND WFYFNNLLEY DNYHLIILYE FFRKFDVENL 
       160        170        180        190        200
KAKQKKELGS SSFNLKAADD RIKSINYGNR FLSFDDLLLN LNQFKDTIRL 
       210        220        230        240        250
LHESIDDNFV KDNKLLLDWN DFRFLKFYKC YHENEEYLSL NSLVTILQND 
       260        270        280        290        300
LKNEKIFIGF DRLAQMDSQG HRLALSKNQL TYLLRLFYSH RVSADIFSSL 
       310        320        330        340        350
NLSNTELLKA DNNSIPYNVF KDIFYLFQNF DLLNQIFHKY VTENNLNEQD 
       360        370        380        390        400
IREQIVTKND FMTVLNAQYN KVNNIIEFSP SQINLLFSIV ANSKENRRLR 
       410        420        430        440        450
KRNQDRDDEL LNDHHYDSDI DFFIHNEYLH GVSRSRKNLE SFNDYYHDLS 
       460        470        480        490        500
DGFDQDSGVK KASKASTGLF ESVFGGKKDK ATMRSDLTIE DFMKILNPNY 
       510        520        530        540        550
LNDLVHQMEL QKNQNESLYI NYYFYPIFDS LYNFSLGSIA GCIGATVVYP 
       560        570        580        590        600
IDFIKTRMQA QRSLAQYKNS IDCLLKIISR EGIKGLYSGL GPQLIGVAPE 
       610        620        630        640        650
KAIKLTVNDF MRNRLTDKNG KLSLFPEIIS GASAGACQVI FTNPLEIVKI 
       660        670        680        690        700
RLQVQSDYVG ENIQQANETA TQIVKKLGLR GLYNGVAACL MRDVPFSAIY 
       710        720        730        740        750
FPTYAHLKKD LFDFDPNDKT KRNRLKTWEL LTAGAIAGMP AAFLTTPFDV 
       760        770        780        790        800
IKTRLQIDPR KGETKYNGIF HAIRTILKEE SFRSFFKGGG ARVLRSSPQF 
       810        820        830        840        850
GFTLAAYELF KGFIPSPDNK LKSREGRKRF CIDDDAGNEE TVVHSNGELP 
       860        870        880        890        900
QQKFYSDDRK HANYYYKSCQ IAKTFIDLDN NFSRFDSSVY KNFQEHLRSI 

NG                                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome XVI
   Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
3. SIMILARITY comments
   Index of protein domains and families