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UniProtKB - Q12477 (PCL9_YEAST)
Protein
PHO85 cyclin-9
Gene
PCL9
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. May have a role in bud site selection in G1 phase.
2 PublicationsGO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
- protein kinase binding Source: InterPro
GO - Biological processi
- cell division Source: UniProtKB-KW
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- regulation of establishment or maintenance of cell polarity Source: SGD
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: ComplexPortal
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division |
Names & Taxonomyi
Protein namesi | Recommended name: PHO85 cyclin-9 |
Gene namesi | Name:PCL9 Ordered Locus Names:YDL179W ORF Names:D1408 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002338, PCL9 |
VEuPathDBi | FungiDB:YDL179W |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cellular bud neck Source: SGD
- cyclin-dependent protein kinase holoenzyme complex Source: SGD
- incipient cellular bud site Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271788 | 1 – 304 | PHO85 cyclin-9Add BLAST | 304 |
Proteomic databases
PaxDbi | Q12477 |
Expressioni
Inductioni
By transcription factor SWI5 in a cell cycle-regulated manner. Peaks in late M, early G1 phase (at protein level).2 Publications
Interactioni
Subunit structurei
Forms a cyclin-CDK complex with PHO85.
Binary interactionsi
Q12477
With | #Exp. | IntAct |
---|---|---|
PHO85 [P17157] | 4 | EBI-38090,EBI-13327 |
GO - Molecular functioni
- protein kinase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 31887, 65 interactors |
ComplexPortali | CPX-1697, PCL9-PHO85 kinase complex |
DIPi | DIP-1510N |
IntActi | Q12477, 15 interactors |
MINTi | Q12477 |
STRINGi | 4932.YDL179W |
Miscellaneous databases
RNActi | Q12477, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 146 | Cyclin N-terminalAdd BLAST | 128 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1674, Eukaryota |
GeneTreei | ENSGT00390000000862 |
HOGENOMi | CLU_018149_0_0_1 |
InParanoidi | Q12477 |
OMAi | INTTRHR |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N IPR013922, Cyclin_PHO80-like IPR012104, PHO85_cyclin_1/2/9 |
PANTHERi | PTHR15615, PTHR15615, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF016511, Cyclin_Pcl, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
i Sequence
Sequence statusi: Complete.
Q12477-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISDYDALLQ FNKKPVSQEM IQFLATSTAS IIKIRENNNP IQGCRPPDLS
60 70 80 90 100
IFIKNVVIQS NVQTPTLMAT SVYLNKLKSV IPKNVYGINT TRHRIFLGCL
110 120 130 140 150
ILAAKTLNDS SPWNKHWTTY TEGLLRIREV NTIERELLEY LNWDVRITTP
160 170 180 190 200
DLIDSLSYFL GPIKEQLFLQ RRQEMLLFNA PSPGQLKEYI NHRRPVSHSR
210 220 230 240 250
TSSAISVPSL TSMATVSTTD SRSSLLAKYQ PSLPLVESDN FNKKNHVPLR
260 270 280 290 300
NNNDICNNFR AEENIHSVNH IDVTMGSSPV MSHKPTIHQR LNFTRRGWSS
FFKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z67750 Genomic DNA Translation: CAA91566.1 Z74227 Genomic DNA Translation: CAA98753.1 AY557655 Genomic DNA Translation: AAS55981.1 BK006938 Genomic DNA Translation: DAA11683.1 |
PIRi | S61033 |
RefSeqi | NP_010102.1, NM_001180239.1 |
Genome annotation databases
EnsemblFungii | YDL179W_mRNA; YDL179W; YDL179W |
GeneIDi | 851375 |
KEGGi | sce:YDL179W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z67750 Genomic DNA Translation: CAA91566.1 Z74227 Genomic DNA Translation: CAA98753.1 AY557655 Genomic DNA Translation: AAS55981.1 BK006938 Genomic DNA Translation: DAA11683.1 |
PIRi | S61033 |
RefSeqi | NP_010102.1, NM_001180239.1 |
3D structure databases
SMRi | Q12477 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31887, 65 interactors |
ComplexPortali | CPX-1697, PCL9-PHO85 kinase complex |
DIPi | DIP-1510N |
IntActi | Q12477, 15 interactors |
MINTi | Q12477 |
STRINGi | 4932.YDL179W |
Proteomic databases
PaxDbi | Q12477 |
Genome annotation databases
EnsemblFungii | YDL179W_mRNA; YDL179W; YDL179W |
GeneIDi | 851375 |
KEGGi | sce:YDL179W |
Organism-specific databases
SGDi | S000002338, PCL9 |
VEuPathDBi | FungiDB:YDL179W |
Phylogenomic databases
eggNOGi | KOG1674, Eukaryota |
GeneTreei | ENSGT00390000000862 |
HOGENOMi | CLU_018149_0_0_1 |
InParanoidi | Q12477 |
OMAi | INTTRHR |
Miscellaneous databases
PROi | PR:Q12477 |
RNActi | Q12477, protein |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N IPR013922, Cyclin_PHO80-like IPR012104, PHO85_cyclin_1/2/9 |
PANTHERi | PTHR15615, PTHR15615, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF016511, Cyclin_Pcl, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PCL9_YEAST | |
Accessioni | Q12477Primary (citable) accession number: Q12477 Secondary accession number(s): D6VRH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - SIMILARITY comments
Index of protein domains and families