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UniProtKB - Q12458 (YPR1_YEAST)
Protein
Putative reductase 1
Gene
YPR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 14100 molecules/cell in log phase SD medium.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 56 | Proton donorBy similarity | 1 | |
Sitei | 81 | Lowers pKa of active site TyrBy similarity | 1 | |
Binding sitei | 112 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 220 – 274 | NADPBy similarityAdd BLAST | 55 |
GO - Molecular functioni
- alditol:NADP+ 1-oxidoreductase activity Source: SGD
- carbonyl reductase (NADPH) activity Source: SGD
GO - Biological processi
- arabinose catabolic process Source: SGD
- cellular response to oxidative stress Source: SGD
- D-xylose catabolic process Source: SGD
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:YPR1 Ordered Locus Names:YDR368W ORF Names:D9481.8 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002776, YPR1 |
VEuPathDBi | FungiDB:YDR368W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124612 | 1 – 312 | Putative reductase 1Add BLAST | 312 |
Proteomic databases
MaxQBi | Q12458 |
PaxDbi | Q12458 |
PRIDEi | Q12458 |
PTM databases
iPTMneti | Q12458 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 32427, 50 interactors |
DIPi | DIP-4334N |
IntActi | Q12458, 1 interactor |
MINTi | Q12458 |
STRINGi | 4932.YDR368W |
Miscellaneous databases
RNActi | Q12458, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldo/keto reductase family.Curated
Phylogenomic databases
eggNOGi | KOG1577, Eukaryota |
GeneTreei | ENSGT00940000176580 |
HOGENOMi | CLU_023205_0_0_1 |
InParanoidi | Q12458 |
OMAi | WRSENND |
Family and domain databases
CDDi | cd19117, AKR_AKR3A1-2, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR020471, AKR IPR044489, AKR3A IPR018170, Aldo/ket_reductase_CS IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PIRSFi | PIRSF000097, AKR, 1 hit |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00798, ALDOKETO_REDUCTASE_1, 1 hit PS00062, ALDOKETO_REDUCTASE_2, 1 hit PS00063, ALDOKETO_REDUCTASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q12458-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPATLKNSSA TLKLNTGASI PVLGFGTWRS VDNNGYHSVI AALKAGYRHI
60 70 80 90 100
DAAAIYLNEE EVGRAIKDSG VPREEIFITT KLWGTEQRDP EAALNKSLKR
110 120 130 140 150
LGLDYVDLYL MHWPVPLKTD RVTDGNVLCI PTLEDGTVDI DTKEWNFIKT
160 170 180 190 200
WELMQELPKT GKTKAVGVSN FSINNIKELL ESPNNKVVPA TNQIEIHPLL
210 220 230 240 250
PQDELIAFCK EKGIVVEAYS PFGSANAPLL KEQAIIDMAK KHGVEPAQLI
260 270 280 290 300
ISWSIQRGYV VLAKSVNPER IVSNFKIFTL PEDDFKTISN LSKVHGTKRV
310
VDMKWGSFPI FQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80642 Genomic DNA Translation: CAA56686.1 U28373 Genomic DNA Translation: AAB64804.1 BK006938 Genomic DNA Translation: DAA12209.1 |
PIRi | S61163 |
RefSeqi | NP_010656.1, NM_001180676.1 |
Genome annotation databases
EnsemblFungii | YDR368W_mRNA; YDR368W; YDR368W |
GeneIDi | 851974 |
KEGGi | sce:YDR368W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80642 Genomic DNA Translation: CAA56686.1 U28373 Genomic DNA Translation: AAB64804.1 BK006938 Genomic DNA Translation: DAA12209.1 |
PIRi | S61163 |
RefSeqi | NP_010656.1, NM_001180676.1 |
3D structure databases
AlphaFoldDBi | Q12458 |
SMRi | Q12458 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32427, 50 interactors |
DIPi | DIP-4334N |
IntActi | Q12458, 1 interactor |
MINTi | Q12458 |
STRINGi | 4932.YDR368W |
PTM databases
iPTMneti | Q12458 |
Proteomic databases
MaxQBi | Q12458 |
PaxDbi | Q12458 |
PRIDEi | Q12458 |
Genome annotation databases
EnsemblFungii | YDR368W_mRNA; YDR368W; YDR368W |
GeneIDi | 851974 |
KEGGi | sce:YDR368W |
Organism-specific databases
SGDi | S000002776, YPR1 |
VEuPathDBi | FungiDB:YDR368W |
Phylogenomic databases
eggNOGi | KOG1577, Eukaryota |
GeneTreei | ENSGT00940000176580 |
HOGENOMi | CLU_023205_0_0_1 |
InParanoidi | Q12458 |
OMAi | WRSENND |
Miscellaneous databases
PROi | PR:Q12458 |
RNActi | Q12458, protein |
Family and domain databases
CDDi | cd19117, AKR_AKR3A1-2, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR020471, AKR IPR044489, AKR3A IPR018170, Aldo/ket_reductase_CS IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PIRSFi | PIRSF000097, AKR, 1 hit |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00798, ALDOKETO_REDUCTASE_1, 1 hit PS00062, ALDOKETO_REDUCTASE_2, 1 hit PS00063, ALDOKETO_REDUCTASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YPR1_YEAST | |
Accessioni | Q12458Primary (citable) accession number: Q12458 Secondary accession number(s): D6VSZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - SIMILARITY comments
Index of protein domains and families