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Protein

Protein AHC1

Gene

AHC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the transcription regulatory histone acetylation (HAT) complex ADA. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. AHC1 is required for the overall structural integrity of the ADA complex.3 Publications

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • histone acetylation Source: SGD
  • replication-born double-strand break repair via sister chromatid exchange Source: SGD

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33571-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AHC1
Alternative name(s):
ADA HAT complex component 1
Gene namesi
Name:AHC1
Ordered Locus Names:YOR023C
ORF Names:OR26.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

SGDiS000005549 AHC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002278041 – 566Protein AHC1Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineCombined sources1
Modified residuei505PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12433
PaxDbiQ12433
PRIDEiQ12433

PTM databases

iPTMnetiQ12433

Interactioni

Subunit structurei

Component of the 0.8 MDa ADA complex, which at least consists of ADA2, ADA3, AHC1 and GCN5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AHC2P256495EBI-33947,EBI-21993

Protein-protein interaction databases

BioGridi34427, 224 interactors
ComplexPortaliCPX-608 Ada2/Gcn5/Ada3 transcription activator complex
DIPiDIP-896N
IntActiQ12433, 8 interactors
MINTiQ12433
STRINGi4932.YOR023C

Structurei

3D structure databases

ProteinModelPortaliQ12433
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000033862
InParanoidiQ12433
KOiK11370
OMAiHHRRNYS
OrthoDBiEOG092C3MZO

Family and domain databases

InterProiView protein in InterPro
IPR037807 AHC1
PANTHERiPTHR13585:SF19 PTHR13585:SF19, 2 hits

Sequencei

Sequence statusi: Complete.

Q12433-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSPAQDKLQ HQHHNPNSSS SSSSKMTNVY QVTTPKSPQD LENNMDEPFK
60 70 80 90 100
MDTATSNPDK DSENTQRLKY ECAKGEIQNV LNLHIMLNHK HVRHLRRNVQ
110 120 130 140 150
KVNAKLALLE TLHKDTGLLN KIERTYQLKI KQHQQHSVLG GHFHDSTATE
160 170 180 190 200
NTNASNYNLS YPVLSDYNIN CQPLSSSSNR NLSTTRIPHH HYHTRSKSNG
210 220 230 240 250
LLLEPSALRP ANSNIIDYRL TGSKSLSEAI TKPTPVSLPH SNSDGISSPR
260 270 280 290 300
SSSISPLDEQ PGFQILPFKP SQMHLNHRRN YSSTCLTSNS GIIGKTENNE
310 320 330 340 350
PIFRRYDGIL VIITCSKCDR SGFTSAQGIV NHTRLKHSKL YSSQPLAVLN
360 370 380 390 400
NQKLLPNDKQ DPEILSKFKK LNLDPNKDYL PSDIAIPKPQ SPINHSENHT
410 420 430 440 450
RAPKTVKNTP HLEKLYQNKE DFKKLIDMVN ETPDDLNEYL KQREIQLRYQ
460 470 480 490 500
KEQEEESSKS DDEASYVPSP SLSATATTTT TTDPPSPPVL SSSLQRKLLR
510 520 530 540 550
KRKLSLNSST PMEDLPLRER LRANPTDKKP RKAALLTNEL EGPDPAAKSS
560
SYYNLRSKSR LRGSHT
Length:566
Mass (Da):63,869
Last modified:November 1, 1996 - v1
Checksum:iC18AFA10E4334764
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74931 Genomic DNA Translation: CAA99213.1
X87331 Genomic DNA Translation: CAA60772.1
BK006948 Genomic DNA Translation: DAA10806.1
PIRiS54629
RefSeqiNP_014666.1, NM_001183442.1

Genome annotation databases

EnsemblFungiiYOR023C; YOR023C; YOR023C
GeneIDi854188
KEGGisce:YOR023C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74931 Genomic DNA Translation: CAA99213.1
X87331 Genomic DNA Translation: CAA60772.1
BK006948 Genomic DNA Translation: DAA10806.1
PIRiS54629
RefSeqiNP_014666.1, NM_001183442.1

3D structure databases

ProteinModelPortaliQ12433
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34427, 224 interactors
ComplexPortaliCPX-608 Ada2/Gcn5/Ada3 transcription activator complex
DIPiDIP-896N
IntActiQ12433, 8 interactors
MINTiQ12433
STRINGi4932.YOR023C

PTM databases

iPTMnetiQ12433

Proteomic databases

MaxQBiQ12433
PaxDbiQ12433
PRIDEiQ12433

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR023C; YOR023C; YOR023C
GeneIDi854188
KEGGisce:YOR023C

Organism-specific databases

SGDiS000005549 AHC1

Phylogenomic databases

HOGENOMiHOG000033862
InParanoidiQ12433
KOiK11370
OMAiHHRRNYS
OrthoDBiEOG092C3MZO

Enzyme and pathway databases

BioCyciYEAST:G3O-33571-MONOMER

Miscellaneous databases

PROiPR:Q12433

Family and domain databases

InterProiView protein in InterPro
IPR037807 AHC1
PANTHERiPTHR13585:SF19 PTHR13585:SF19, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAHC1_YEAST
AccessioniPrimary (citable) accession number: Q12433
Secondary accession number(s): D6W290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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