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Entry version 127 (31 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Protein PNS1

Gene

PNS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in transport through the plasma membrane.By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-33678-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.92.1.8 the choline transporter-like (ctl) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PNS1
Alternative name(s):
pH nine-sensitive protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNS1
Ordered Locus Names:YOR161C
ORF Names:O3568
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YOR161C

Saccharomyces Genome Database

More...
SGDi
S000005687 PNS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 129ExtracellularSequence analysisAdd BLAST27
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 157CytoplasmicSequence analysis7
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 182ExtracellularSequence analysis4
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 226CytoplasmicSequence analysisAdd BLAST23
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 274ExtracellularSequence analysisAdd BLAST27
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 332CytoplasmicSequence analysisAdd BLAST37
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 371ExtracellularSequence analysisAdd BLAST18
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 436CytoplasmicSequence analysisAdd BLAST44
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 473ExtracellularSequence analysisAdd BLAST16
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 539CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917401 – 539Protein PNS1Add BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q12412

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12412

PRoteomics IDEntifications database

More...
PRIDEi
Q12412

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12412

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34557, 40 interactors

Database of interacting proteins

More...
DIPi
DIP-1858N

Protein interaction database and analysis system

More...
IntActi
Q12412, 3 interactors

Molecular INTeraction database

More...
MINTi
Q12412

STRING: functional protein association networks

More...
STRINGi
4932.YOR161C

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000198767

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12412

Identification of Orthologs from Complete Genome Data

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OMAi
VSKKYGH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007603 Choline_transptr-like

The PANTHER Classification System

More...
PANTHERi
PTHR12385 PTHR12385, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04515 Choline_transpo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLNEKYERP PQPPPAYDPN HRPPSSSENS AAANVNDGQT PYHFRQDQYY
60 70 80 90 100
NLNSKTSGAP IGSFDEAFPT ENDNKPRWND WPFTIFFLCT VGGFIAIAAI
110 120 130 140 150
TLRAWSQTYS STGSGIYDGV NTGTLNTNAA ILLVFVCIIA LVFSVLGLTL
160 170 180 190 200
CRIFPKQFIY CGMVINLVAS LGTAIMYMSL RYWSAGIVFL VFTFMTAWCY
210 220 230 240 250
WGMRSRIPLS VAVLKVVVDA MKKCPQIFFV SFVGALVASA FGFLFSAVIV
260 270 280 290 300
ATYIKYDPNS SNGGCDVSGG SCSHSKLIGV LVVVFFCGYY ISEVIRNVIH
310 320 330 340 350
CVISGVFGSW YYMSKSDQGM PRWPAFGALK RAMTYSFGSI CFGSLLVALI
360 370 380 390 400
DLLRQILQMI RHDVTSSGGG QIAIQILFMV FDWIIGFLKW LAEYFNHYAY
410 420 430 440 450
SFIALYGKPY LRAAKETWYM LREKGMDALI NDNLINIALG LFSMFASYMT
460 470 480 490 500
ALFTFLYLRF TSPQYNSNGA YNGALMAFSF VIALQICNIA TEAIRSGTAT
510 520 530
FFVALGNDPE VFHHSYPHRF DEIFRAYPDV LRKLSHQNV
Length:539
Mass (Da):60,251
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3560F6E665AF27BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti181R → K in AAT92656 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z75069 Genomic DNA Translation: CAA99367.1
U55021 Genomic DNA Translation: AAB47408.1
AY692637 Genomic DNA Translation: AAT92656.1
BK006948 Genomic DNA Translation: DAA10934.1

Protein sequence database of the Protein Information Resource

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PIRi
S67049

NCBI Reference Sequences

More...
RefSeqi
NP_014804.3, NM_001183580.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR161C_mRNA; YOR161C_mRNA; YOR161C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854332

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR161C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75069 Genomic DNA Translation: CAA99367.1
U55021 Genomic DNA Translation: AAB47408.1
AY692637 Genomic DNA Translation: AAT92656.1
BK006948 Genomic DNA Translation: DAA10934.1
PIRiS67049
RefSeqiNP_014804.3, NM_001183580.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi34557, 40 interactors
DIPiDIP-1858N
IntActiQ12412, 3 interactors
MINTiQ12412
STRINGi4932.YOR161C

Protein family/group databases

TCDBi2.A.92.1.8 the choline transporter-like (ctl) family

PTM databases

iPTMnetiQ12412

Proteomic databases

MaxQBiQ12412
PaxDbiQ12412
PRIDEiQ12412

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR161C_mRNA; YOR161C_mRNA; YOR161C
GeneIDi854332
KEGGisce:YOR161C

Organism-specific databases

EuPathDBiFungiDB:YOR161C
SGDiS000005687 PNS1

Phylogenomic databases

HOGENOMiHOG000198767
InParanoidiQ12412
OMAiVSKKYGH

Enzyme and pathway databases

BioCyciYEAST:G3O-33678-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12412

Family and domain databases

InterProiView protein in InterPro
IPR007603 Choline_transptr-like
PANTHERiPTHR12385 PTHR12385, 1 hit
PfamiView protein in Pfam
PF04515 Choline_transpo, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNS1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12412
Secondary accession number(s): D6W2L8, Q6B2U3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: July 31, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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