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UniProtKB - Q12397 (STCA_EMENI)
Protein
Putative sterigmatocystin biosynthesis polyketide synthase
Gene
stcA
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Involved in the synthesis of the polyketide nucleus of sterigmatocystin from hexanoyl-CoA and seven malonates.
Cofactori
pantetheine 4'-phosphateCuratedNote: Binds 2 phosphopantetheines covalently.Curated
: sterigmatocystin biosynthesis Pathwayi
This protein is involved in the pathway sterigmatocystin biosynthesis, which is part of Mycotoxin biosynthesis.View all proteins of this organism that are known to be involved in the pathway sterigmatocystin biosynthesis and in Mycotoxin biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 552 | For beta-ketoacyl synthase activityBy similarity | 1 | |
Active sitei | 1004 | For acyl/malonyl transferase activityBy similarity | 1 | |
Active sitei | 2039 | For thioesterase activityBy similarity | 1 |
GO - Molecular functioni
- fatty acid synthase activity Source: GO_Central
- phosphopantetheine binding Source: InterPro
GO - Biological processi
- emericellamide biosynthetic process Source: AspGD
- fatty acid biosynthetic process Source: GO_Central
- monodictyphenone biosynthetic process Source: AspGD
- o-orsellinic acid biosynthetic process Source: AspGD
- secondary metabolic process Source: AspGD
- secondary metabolite biosynthetic process Source: GO_Central
- sterigmatocystin biosynthetic process Source: AspGD
Keywordsi
Molecular function | Acyltransferase, Multifunctional enzyme, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00377 |
Protein family/group databases
ESTHERi | emeni-stca, Thioesterase |
Names & Taxonomyi
Protein namesi | Recommended name: Putative sterigmatocystin biosynthesis polyketide synthaseShort name: PKS |
Gene namesi | Name:stcA Synonyms:pksST ORF Names:AN7825 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:AN7825 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180304 | 1 – 2211 | Putative sterigmatocystin biosynthesis polyketide synthaseAdd BLAST | 2211 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1749 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 1873 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1712 – 1791 | Carrier 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 1839 – 1915 | Carrier 2PROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | ? – 2192 | Thioesterase | ||
Regioni | 358 – 378 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 383 – 814 | Beta-ketoacyl synthaseAdd BLAST | 432 | |
Regioni | 910 – 1235 | Acyl/malonyl transferasesAdd BLAST | 326 | |
Regioni | 1289 – 1316 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1655 – 1706 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1912 – 1947 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1655 – 1699 | Polar residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 1912 – 1943 | Polar residuesSequence analysisAdd BLAST | 32 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_6_0_1 |
InParanoidi | Q12397 |
OMAi | AKWGCER |
OrthoDBi | 68112at2759 |
Family and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.10.129.110, 1 hit 3.40.366.10, 2 hits 3.40.47.10, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR030918, PT_fungal_PKS IPR032088, SAT IPR001031, Thioesterase IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF00550, PP-binding, 2 hits PF14765, PS-DH, 1 hit PF16073, SAT, 1 hit PF00975, Thioesterase, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00825, PKS_KS, 1 hit SM00823, PKS_PP, 2 hits |
SUPFAMi | SSF47336, SSF47336, 2 hits SSF52151, SSF52151, 1 hit SSF53474, SSF53474, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
TIGRFAMsi | TIGR04532, PT_fungal_PKS, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 2 hits |
i Sequence
Sequence statusi: Complete.
Q12397-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASHAEPTRL FLFGDQTYDF VADLRDLLNI RNNPILVAFL EQSHHVIRAQ
60 70 80 90 100
MIRELPPKEH KQARTASLAE LLQKYVDRKL PSAFQTALSC VTQIGLFMRQ
110 120 130 140 150
FDDPRVLYPH ANDSYVLGVC TGSLAAAAIS CSTSLSELLP IAVQTVLVAF
160 170 180 190 200
RLGLWAEKVR DNLEISETNQ TQPWSAVCHV PPEEVAIAID RFSHKKVRSP
210 220 230 240 250
VYRAQRPWIT ATSAKTTTVS ASPDILSQLA SQAPFTNSKL WREIPIYVPA
260 270 280 290 300
HNNHLFSSRD VDDILATTNE NPWSTFGAQI PFLSSVTGKL AWVRNYRDLL
310 320 330 340 350
HLALSQCLIE PIRWDVVEAE VPRLLKDRDG LDTLTIVAFT TVLSKSLSNA
360 370 380 390 400
LVTEGIKPAE PPTSINKTPE RYSHRPGSDR GKLAIVSMSG RFPEAPSTDS
410 420 430 440 450
FWDLLYKGLD VCKEVPLRRW DVKTHVDPSG KARNKGATRW GCWLDFAGEF
460 470 480 490 500
DPRFFSISPK EAPQMDPAQR MALMSTYEAM ERGGIVPDTT PSTQRNRIGV
510 520 530 540 550
FHGVTSNDWM ETNTAQNIDT YFITGGNRGF IPGRINFCFE FSGPSYSNDT
560 570 580 590 600
ACSSSLAAIH LACNSLWRGD CDTAVAGGTN MIFTPDGHTG LDKGFFLSRT
610 620 630 640 650
GNCKAFDDAA DGYCRAEGVG TVFIKRLEDA LAENDPILAT ILDIKTNHSA
660 670 680 690 700
MSDSMTRPFK PAQIDNMSAL LSTAGISPLD LSYIEMHGTG TQVGDAVEME
710 720 730 740 750
SVLSLFAPDE TFRPRDKPLY VGSAKANIGH GEGVSGVTSL IKVLLMMKND
760 770 780 790 800
TIPPHCGIKP GSRINRNYPD LPARNVHIAF EPKPWPRTDT PRRVLINNFS
810 820 830 840 850
AAGGNTAVLV EDAPVRDPVT ASDPRTSHIV TVSGHVGKSL KLNLEKLRDH
860 870 880 890 900
LVKRPEINPS ELSYTTTARR WHHPHRVSIT GANTMEILRN VESAIARGHG
910 920 930 940 950
VNRPATKPKI VIACSGQGSQ YTGMGWQLYN SYPTFRSDLE RFDQLARSYG
960 970 980 990 1000
FPSFLEVYTS KPVGDSMEDL LPVIVQLALV SLEMALGNLL GSFGLKPSAV
1010 1020 1030 1040 1050
IGHSLGEYAA LYISGVLSAA DTLYLVGMRA KLLQERCQRG THAMLAVRAS
1060 1070 1080 1090 1100
PVTLCEVLAE SNCEVACHNG PNDTVLSGPL KEVMNLQNSL SATGIKGTLL
1110 1120 1130 1140 1150
KLPFAFHSAQ VQPILEEFKN VARGVTFHKP QIPVLSPLLV KVIDEKGTVD
1160 1170 1180 1190 1200
PVYLARHCRE PVKMVSVLEH ARDQHIITDR TIVIDVGPKA LMAGMIKTTL
1210 1220 1230 1240 1250
DKDTSSALPT LGPSLDVWKS LTNILGTLYS RGLDINWVAY HEPFGSAKKV
1260 1270 1280 1290 1300
IELPSYGWDL KDYFIPYKGE WCLHRHEIRC SCATPGKETA TSDYQLPSDE
1310 1320 1330 1340 1350
QVAAKRPSKQ DESKEAYPEI VATTTVHRVV EEKTEPLGAT LVVETDISRP
1360 1370 1380 1390 1400
DVNQIAQGHL VDGIPLCTPS VYADIALHVG RYSMNRLRAS HPGAMDGVVD
1410 1420 1430 1440 1450
VADMVIDKAL IPHGKSPQLL RTTLTMTWPP KAAATTRSAK IKFATYFADG
1460 1470 1480 1490 1500
KLDTEHATCT VRFTSEAQLK SLQKKVPEYQ ERIKKLGEGL RQGQFIRYTT
1510 1520 1530 1540 1550
KSGYKLMSSM ASFHRDYKLL NHLILNEADN EAVSTMDFSA AKSEGTFAAH
1560 1570 1580 1590 1600
PAYVDAITQV GGFAMNANDN TDIQQEVFVN HGWDSFQVYQ PLVKGKTYEV
1610 1620 1630 1640 1650
YVRMTEDEKG DLVHGDTIVL YGDAVVAFFK GLSLRRVPRR GLRMVLQQAS
1660 1670 1680 1690 1700
DKAARLHGNQ QAVKTQAPQR AALKQKPQSS PTQPHASKVA YSRSATSPTA
1710 1720 1730 1740 1750
GKPVVAARDL SREGDDKFKA VLSVISEESG VALGELTADT NFADIGIDSL
1760 1770 1780 1790 1800
SSMVIGSRLR EDLGLELGAE FSLFIDCPTV RSLKTLLSGS AVSVNNDKDE
1810 1820 1830 1840 1850
LEPGQEAETA APEQLDLRIG DAAPSKVRDA NIEPLDLGDE LFRNVLRIVS
1860 1870 1880 1890 1900
EESGVALDEL SAETVFADIG IDSLSSMVIT SRFREDLGMS LDSSFNLFEE
1910 1920 1930 1940 1950
VPTVARLQEF FGTTSGSTTG SSGSGSSEDE TDSIPSTPEE YTTADTRVPE
1960 1970 1980 1990 2000
CRPTTSVVLQ GLPQMAKQIL FMLPDGGGSA SSYLTIPRLH ADVAIVGLNC
2010 2020 2030 2040 2050
PYARDPENMN CTHQSMIQSF CNEIKRRQPE GPYHLGGWSS GGAFAYVTAE
2060 2070 2080 2090 2100
ALINAGNEVH SLIIIDAPVP QVMEKLPTSF YEYCNNLGLF SNQPGGTTDG
2110 2120 2130 2140 2150
TAQPPPYLIP HFQATVDVML DYRVAPLKTN RMPKVGIIWA SETVMDEDNA
2160 2170 2180 2190 2200
PKMKGMHFMV QKRKDFGPDG WDVVCPGAVF DIVRAEGANH FTLMTKEHVY
2210
LVRELIDRVM G
Sequence cautioni
The sequence AAA81586 differs from that shown. Reason: Frameshift.Curated
The sequence AAA81586 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC49191 differs from that shown. Reason: Frameshift.Curated
The sequence AAC49191 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA61613 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1584 | D → T in AAA81586 (PubMed:7642507).Curated | 1 | |
Sequence conflicti | 1584 | D → T in AAC49191 (PubMed:8643646).Curated | 1 | |
Sequence conflicti | 1940 | E → A in AAA81586 (PubMed:7642507).Curated | 1 | |
Sequence conflicti | 1940 | E → A in AAC49191 (PubMed:8643646).Curated | 1 | |
Sequence conflicti | 2164 | K → W in AAA81586 (PubMed:7642507).Curated | 1 | |
Sequence conflicti | 2164 | K → W in AAC49191 (PubMed:8643646).Curated | 1 | |
Sequence conflicti | 2183 | V → L in AAA81586 (PubMed:7642507).Curated | 1 | |
Sequence conflicti | 2183 | V → L in AAC49191 (PubMed:8643646).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39121 Genomic DNA Translation: AAA81586.1 Sequence problems. U34740 Genomic DNA Translation: AAC49191.1 Sequence problems. AACD01000132 Genomic DNA Translation: EAA61613.1 Sequence problems. BN001304 Genomic DNA Translation: CBF80184.1 |
RefSeqi | XP_681094.1, XM_676002.1 |
Genome annotation databases
EnsemblFungii | CBF80184; CBF80184; ANIA_07825 EAA61613; EAA61613; AN7825.2 |
GeneIDi | 2869640 |
KEGGi | ani:AN7825.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L39121 Genomic DNA Translation: AAA81586.1 Sequence problems. U34740 Genomic DNA Translation: AAC49191.1 Sequence problems. AACD01000132 Genomic DNA Translation: EAA61613.1 Sequence problems. BN001304 Genomic DNA Translation: CBF80184.1 |
RefSeqi | XP_681094.1, XM_676002.1 |
3D structure databases
SMRi | Q12397 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 227321.Q12397 |
Protein family/group databases
ESTHERi | emeni-stca, Thioesterase |
Genome annotation databases
EnsemblFungii | CBF80184; CBF80184; ANIA_07825 EAA61613; EAA61613; AN7825.2 |
GeneIDi | 2869640 |
KEGGi | ani:AN7825.2 |
Organism-specific databases
VEuPathDBi | FungiDB:AN7825 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_6_0_1 |
InParanoidi | Q12397 |
OMAi | AKWGCER |
OrthoDBi | 68112at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00377 |
Family and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.10.129.110, 1 hit 3.40.366.10, 2 hits 3.40.47.10, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR030918, PT_fungal_PKS IPR032088, SAT IPR001031, Thioesterase IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF00550, PP-binding, 2 hits PF14765, PS-DH, 1 hit PF16073, SAT, 1 hit PF00975, Thioesterase, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00825, PKS_KS, 1 hit SM00823, PKS_PP, 2 hits |
SUPFAMi | SSF47336, SSF47336, 2 hits SSF52151, SSF52151, 1 hit SSF53474, SSF53474, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
TIGRFAMsi | TIGR04532, PT_fungal_PKS, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | STCA_EMENI | |
Accessioni | Q12397Primary (citable) accession number: Q12397 Secondary accession number(s): C8VDU9, Q5AV55 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 26, 2009 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways