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Protein

tRNA:m(4)X modification enzyme TRM13

Gene

TRM13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

tRNA methylase which 2'-O-methylates cytidine4 in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine4 in tRNA(His).1 Publication

Miscellaneous

Present with 1230 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + cytidine4 in tRNA(Pro) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Pro).1 Publication
S-adenosyl-L-methionine + cytidine4 in tRNA(Gly)(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Gly)(GCC).1 Publication
S-adenosyl-L-methionine + adenosine4 in tRNA(His) = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNA(His).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 99CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • tRNA methylation Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:G3O-33521-MONOMER
YEAST:G3O-33521-MONOMER
BRENDAi2.1.1.225 984

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA:m(4)X modification enzyme TRM13 (EC:2.1.1.225)
Alternative name(s):
tRNA methylase 13
Gene namesi
Name:TRM13
Ordered Locus Names:YOL125W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL125W
SGDiS000005485 TRM13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002359321 – 476tRNA:m(4)X modification enzyme TRM13Add BLAST476

Proteomic databases

MaxQBiQ12383
PaxDbiQ12383
PRIDEiQ12383

PTM databases

iPTMnetiQ12383

Interactioni

Protein-protein interaction databases

BioGridi34250, 28 interactors
IntActiQ12383, 5 interactors
MINTiQ12383
STRINGi4932.YOL125W

Structurei

3D structure databases

ProteinModelPortaliQ12383
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase TRM13 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 99CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000003182
HOGENOMiHOG000000772
InParanoidiQ12383
KOiK15446
OMAiLIALCCH
OrthoDBiEOG092C2SYB

Family and domain databases

InterProiView protein in InterPro
IPR007871 Methyltransferase_TRM13
IPR039044 Trm13
IPR022776 TRM13/UPF0224_CHHC_Znf_dom
IPR021721 Znf_CCCH-type_TRM13
PANTHERiPTHR12998 PTHR12998, 1 hit
PfamiView protein in Pfam
PF05206 TRM13, 1 hit
PF11722 zf-TRM13_CCCH, 1 hit
PF05253 zf-U11-48K, 1 hit
PROSITEiView protein in PROSITE
PS51800 ZF_CHHC_U11_48K, 1 hit

Sequencei

Sequence statusi: Complete.

Q12383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQDNNGPAV KRAKPSERLQ CEYFMEKKKR RCGMTRSSQN LYCSEHLNLM
60 70 80 90 100
KKAANSQVHN KNGSEAEKER ERVPCPLDPN HTVWADQLKK HLKKCNKTKL
110 120 130 140 150
SHLNDDKPYY EPGYNGENGL LSSSVKIDIT AEHLVQSIEL LYKVFEGESM
160 170 180 190 200
DELPLRQLNN KLMSLKRFPQ LPSNTKHAVQ QSSLIENLVD AGAFERPESL
210 220 230 240 250
NFIEFGCGRA EFSRYVSLYL LTQLTSLPAE HSGSNSNEFV LIDRATNRMK
260 270 280 290 300
FDKKIKDDFS EIKSNSPSKP ISCPSIKRIK IDIRDLKMDP ILKSTPGDDI
310 320 330 340 350
QYVCISKHLC GVATDLTLRC IGNSSILHGD DNNGCNPKLK AICIAMCCRH
360 370 380 390 400
VCDYGDYVNR SYVTSLVEKY RAHGSILTYE TFFRVLTKLC SWGTCGRKPG
410 420 430 440 450
TAITDIVNVV ESFEGAEPYT ITIKERENIG LMARRVIDEG RLVYVKEKFT
460 470
EFNAELIRYV ESDVSLENVA MLVYKK
Length:476
Mass (Da):54,095
Last modified:November 1, 1996 - v1
Checksum:i3280A732FFA374C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41293 Genomic DNA Translation: AAC49467.1
Z74867 Genomic DNA Translation: CAA99144.1
BK006948 Genomic DNA Translation: DAA10659.1
PIRiS63445
RefSeqiNP_014516.1, NM_001183379.2

Genome annotation databases

EnsemblFungiiYOL125W; YOL125W; YOL125W
GeneIDi853995
KEGGisce:YOL125W

Similar proteinsi

Entry informationi

Entry nameiTRM13_YEAST
AccessioniPrimary (citable) accession number: Q12383
Secondary accession number(s): D6W1U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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