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UniProtKB - Q12375 (ORT1_YEAST)
Protein
Mitochondrial ornithine transporter 1
Gene
ORT1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for arginine biosynthesis. Transports ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol, where it is converted to arginine.
1 PublicationMiscellaneous
Present with 432 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- L-ornithine transmembrane transporter activity Source: SGD
GO - Biological processi
- arginine biosynthetic process Source: SGD
- mitochondrial L-ornithine transmembrane transport Source: SGD
Keywordsi
Biological process | Amino-acid biosynthesis, Arginine biosynthesis, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-70635, Urea cycle |
Protein family/group databases
TCDBi | 2.A.29.9.2, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial ornithine transporter 1 |
Gene namesi | Name:ORT1 Synonyms:ARG11 Ordered Locus Names:YOR130C ORF Names:O3299, YOR3299C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005656, ORT1 |
VEuPathDBi | FungiDB:YOR130C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Mitochondrion
- mitochondrial envelope Source: SGD
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 89 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 171 – 187 | Helical; Name=4Sequence analysisAdd BLAST | 17 | |
Transmembranei | 213 – 233 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 267 – 287 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090684 | 1 – 292 | Mitochondrial ornithine transporter 1Add BLAST | 292 |
Proteomic databases
MaxQBi | Q12375 |
PaxDbi | Q12375 |
PRIDEi | Q12375 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34525, 30 interactors |
DIPi | DIP-8953N |
STRINGi | 4932.YOR130C |
Miscellaneous databases
RNActi | Q12375, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 11 – 97 | Solcar 1Add BLAST | 87 | |
Repeati | 105 – 196 | Solcar 2Add BLAST | 92 | |
Repeati | 211 – 292 | Solcar 3Add BLAST | 82 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0758, Eukaryota |
GeneTreei | ENSGT00940000168956 |
HOGENOMi | CLU_015166_16_3_1 |
InParanoidi | Q12375 |
OMAi | PIDCFRQ |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q12375-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDSKKKGLI EGAILDIING SIAGACGKVI EFPFDTVKVR LQTQASNVFP
60 70 80 90 100
TTWSCIKFTY QNEGIARGFF QGIASPLVGA CLENATLFVS YNQCSKFLEK
110 120 130 140 150
HTNVSPLGQI LISGGVAGSC ASLVLTPVEL VKCKLQVANL QVASAKTKHT
160 170 180 190 200
KVLPTIKAII TERGLAGLWQ GQSGTFIRES FGGVAWFATY EIVKKSLKDR
210 220 230 240 250
HSLDDPKRDE SKIWELLISG GSAGLAFNAS IFPADTVKSV MQTEHISLTN
260 270 280 290
AVKKIFGKFG LKGFYRGLGI TLFRAVPANA AVFYIFETLS AL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 105 | S → F in CAA62118 (PubMed:8904341).Curated | 1 | |
Sequence conflicti | 105 | S → F in CAA64049 (PubMed:9200815).Curated | 1 | |
Sequence conflicti | 105 | S → F in CAA99329 (PubMed:9169874).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87414 Genomic DNA Translation: CAA60862.1 X90518 Genomic DNA Translation: CAA62118.1 X94335 Genomic DNA Translation: CAA64049.1 Z75038 Genomic DNA Translation: CAA99329.1 BK006948 Genomic DNA Translation: DAA10904.2 |
PIRi | S60997 |
RefSeqi | NP_014773.4, NM_001183549.4 |
Genome annotation databases
EnsemblFungii | YOR130C_mRNA; YOR130C; YOR130C |
GeneIDi | 854297 |
KEGGi | sce:YOR130C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87414 Genomic DNA Translation: CAA60862.1 X90518 Genomic DNA Translation: CAA62118.1 X94335 Genomic DNA Translation: CAA64049.1 Z75038 Genomic DNA Translation: CAA99329.1 BK006948 Genomic DNA Translation: DAA10904.2 |
PIRi | S60997 |
RefSeqi | NP_014773.4, NM_001183549.4 |
3D structure databases
AlphaFoldDBi | Q12375 |
SMRi | Q12375 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34525, 30 interactors |
DIPi | DIP-8953N |
STRINGi | 4932.YOR130C |
Protein family/group databases
TCDBi | 2.A.29.9.2, the mitochondrial carrier (mc) family |
Proteomic databases
MaxQBi | Q12375 |
PaxDbi | Q12375 |
PRIDEi | Q12375 |
Genome annotation databases
EnsemblFungii | YOR130C_mRNA; YOR130C; YOR130C |
GeneIDi | 854297 |
KEGGi | sce:YOR130C |
Organism-specific databases
SGDi | S000005656, ORT1 |
VEuPathDBi | FungiDB:YOR130C |
Phylogenomic databases
eggNOGi | KOG0758, Eukaryota |
GeneTreei | ENSGT00940000168956 |
HOGENOMi | CLU_015166_16_3_1 |
InParanoidi | Q12375 |
OMAi | PIDCFRQ |
Enzyme and pathway databases
Reactomei | R-SCE-70635, Urea cycle |
Miscellaneous databases
PROi | PR:Q12375 |
RNActi | Q12375, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ORT1_YEAST | |
Accessioni | Q12375Primary (citable) accession number: Q12375 Secondary accession number(s): D6W2I8, Q92273 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | September 21, 2011 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - SIMILARITY comments
Index of protein domains and families