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Protein

Mitochondrial ornithine transporter 1

Gene

ORT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for arginine biosynthesis. Transports ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol, where it is converted to arginine.1 Publication

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • L-ornithine transmembrane transporter activity Source: SGD

GO - Biological processi

  • arginine biosynthetic process Source: SGD
  • mitochondrial L-ornithine transmembrane transport Source: SGD
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processAmino-acid biosynthesis, Arginine biosynthesis, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33654-MONOMER
ReactomeiR-SCE-70635 Urea cycle

Protein family/group databases

TCDBi2.A.29.9.2 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ornithine transporter 1
Gene namesi
Name:ORT1
Synonyms:ARG11
Ordered Locus Names:YOR130C
ORF Names:O3299, YOR3299C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR130C
SGDiS000005656 ORT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei171 – 187Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906841 – 292Mitochondrial ornithine transporter 1Add BLAST292

Proteomic databases

MaxQBiQ12375
PaxDbiQ12375
PRIDEiQ12375

Interactioni

Protein-protein interaction databases

BioGridi34525, 27 interactors
DIPiDIP-8953N
STRINGi4932.YOR130C

Structurei

3D structure databases

ProteinModelPortaliQ12375
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 97Solcar 1Add BLAST87
Repeati105 – 196Solcar 2Add BLAST92
Repeati211 – 292Solcar 3Add BLAST82

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000110966
HOGENOMiHOG000168307
InParanoidiQ12375
KOiK15114
OMAiYNFLFFP
OrthoDBiEOG092C3A14

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q12375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSKKKGLI EGAILDIING SIAGACGKVI EFPFDTVKVR LQTQASNVFP
60 70 80 90 100
TTWSCIKFTY QNEGIARGFF QGIASPLVGA CLENATLFVS YNQCSKFLEK
110 120 130 140 150
HTNVSPLGQI LISGGVAGSC ASLVLTPVEL VKCKLQVANL QVASAKTKHT
160 170 180 190 200
KVLPTIKAII TERGLAGLWQ GQSGTFIRES FGGVAWFATY EIVKKSLKDR
210 220 230 240 250
HSLDDPKRDE SKIWELLISG GSAGLAFNAS IFPADTVKSV MQTEHISLTN
260 270 280 290
AVKKIFGKFG LKGFYRGLGI TLFRAVPANA AVFYIFETLS AL
Length:292
Mass (Da):31,520
Last modified:September 21, 2011 - v2
Checksum:i3B80DDCC5875FD66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105S → F in CAA62118 (PubMed:8904341).Curated1
Sequence conflicti105S → F in CAA64049 (PubMed:9200815).Curated1
Sequence conflicti105S → F in CAA99329 (PubMed:9169874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87414 Genomic DNA Translation: CAA60862.1
X90518 Genomic DNA Translation: CAA62118.1
X94335 Genomic DNA Translation: CAA64049.1
Z75038 Genomic DNA Translation: CAA99329.1
BK006948 Genomic DNA Translation: DAA10904.2
PIRiS60997
RefSeqiNP_014773.4, NM_001183549.4

Genome annotation databases

EnsemblFungiiYOR130C; YOR130C; YOR130C
GeneIDi854297
KEGGisce:YOR130C

Similar proteinsi

Entry informationi

Entry nameiORT1_YEAST
AccessioniPrimary (citable) accession number: Q12375
Secondary accession number(s): D6W2I8, Q92273
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 21, 2011
Last modified: April 25, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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