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Entry version 136 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

S-methylmethionine permease 1

Gene

MMP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32158-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.10.16 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S-methylmethionine permease 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MMP1
Ordered Locus Names:YLL061W
ORF Names:L0555
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YLL061W

Saccharomyces Genome Database

More...
SGDi
S000003984 MMP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei78 – 96HelicalSequence analysisAdd BLAST19
Topological domaini97 – 101ExtracellularSequence analysis5
Transmembranei102 – 123HelicalSequence analysisAdd BLAST22
Topological domaini124 – 143CytoplasmicSequence analysisAdd BLAST20
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 182ExtracellularSequence analysisAdd BLAST18
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 215CytoplasmicSequence analysisAdd BLAST12
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 254ExtracellularSequence analysisAdd BLAST18
Transmembranei255 – 274HelicalSequence analysisAdd BLAST20
Topological domaini275 – 298CytoplasmicSequence analysisAdd BLAST24
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 356ExtracellularSequence analysisAdd BLAST37
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 402CytoplasmicSequence analysisAdd BLAST25
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 428ExtracellularSequence analysis5
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 473CytoplasmicSequence analysisAdd BLAST24
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 505ExtracellularSequence analysisAdd BLAST11
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 583CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541571 – 583S-methylmethionine permease 1Add BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineBy similarity1
Modified residuei21PhosphothreonineCombined sources1
Modified residuei23PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12372

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12372

PRoteomics IDEntifications database

More...
PRIDEi
Q12372

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12372

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31255, 44 interactors

Database of interacting proteins

More...
DIPi
DIP-8952N

Protein interaction database and analysis system

More...
IntActi
Q12372, 2 interactors

Molecular INTeraction database

More...
MINTi
Q12372

STRING: functional protein association networks

More...
STRINGi
4932.YLL061W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261848

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12372

KEGG Orthology (KO)

More...
KOi
K16261

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHTATIL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00913 2A0310, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12372-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEFESTKLS KVQFSTSVLS TPSNEGNNLI HRFKNSFKRN DSPAIQEGLL
60 70 80 90 100
YSELSEEEKI QWDLANQPYK KVLDQRHLTM IAIGGTLGTG LFIGLGESLA
110 120 130 140 150
SGPASLLIGF LLVGASMLCV VQCGAELSCQ YPVSGSYALH ASRFIDPSVG
160 170 180 190 200
FSIGINYLLM WLISYPSELV GCSLTISYWA PSVNPAAWVA IAFVLSMLLN
210 220 230 240 250
LFGARGFAES EFYMSIFKIV ALFIFIIIGI VLIAGGGPDS TGYIGTKYWH
260 270 280 290 300
DPGSFAVPVF KNLCNTFVSA AYSFSGTEMV VLTSTEARSV SSVSRAAKGT
310 320 330 340 350
FWRIIIFYIV TVIIIGCLVP YNDPRLISGS SSEDITASPF VIALSNTGAM
360 370 380 390 400
GTRVSHFMNA VILIAVFSVC NSCVYASSRL IQGLATAGQL PKICAYMDRN
410 420 430 440 450
GRPLVGMAIC GAFGLLGFLV VSKNQGTVFT WLFALCSISF FTTWFCICFC
460 470 480 490 500
QVRFRMAMKA QGRSKDDIIY RSTLGIYGGI FGCILNVLLV IGEIYVSAAP
510 520 530 540 550
VGSPSSAANF FEYCMSIPIM IAVYIGHRIY RRDWRHWYIK RMDIDLDSGH
560 570 580
SLEDFEATKL ERDEDKKYVS SKPLYYRIYR FFC
Length:583
Mass (Da):64,218
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF88AB299957C5AA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z73166 Genomic DNA Translation: CAA97514.1
Z47973 Genomic DNA Translation: CAA87996.1
BK006945 Genomic DNA Translation: DAA09264.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50959

NCBI Reference Sequences

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RefSeqi
NP_013039.1, NM_001181881.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLL061W_mRNA; YLL061W; YLL061W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLL061W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73166 Genomic DNA Translation: CAA97514.1
Z47973 Genomic DNA Translation: CAA87996.1
BK006945 Genomic DNA Translation: DAA09264.1
PIRiS50959
RefSeqiNP_013039.1, NM_001181881.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi31255, 44 interactors
DIPiDIP-8952N
IntActiQ12372, 2 interactors
MINTiQ12372
STRINGi4932.YLL061W

Protein family/group databases

TCDBi2.A.3.10.16 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiQ12372

Proteomic databases

MaxQBiQ12372
PaxDbiQ12372
PRIDEiQ12372

Genome annotation databases

EnsemblFungiiYLL061W_mRNA; YLL061W; YLL061W
GeneIDi850665
KEGGisce:YLL061W

Organism-specific databases

EuPathDBiFungiDB:YLL061W
SGDiS000003984 MMP1

Phylogenomic databases

HOGENOMiHOG000261848
InParanoidiQ12372
KOiK16261
OMAiHHTATIL

Enzyme and pathway databases

BioCyciYEAST:G3O-32158-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12372

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMP1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12372
Secondary accession number(s): D6VXU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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