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Protein

Protein SFI1

Gene

SFI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication.3 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: SGD
  • spindle assembly Source: SGD
  • spindle pole body duplication Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32108-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SFI1
Alternative name(s):
Suppressor of fermentation induced loss of stress resistance protein 1
Gene namesi
Name:SFI1
Ordered Locus Names:YLL003W
ORF Names:L1373
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL003W
SGDiS000003926 SFI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002696471 – 946Protein SFI1Add BLAST946

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ12369
PRIDEiQ12369

PTM databases

iPTMnetiQ12369

Interactioni

Subunit structurei

Forms a complex with CDC31 and interacts with SPC110. Associates with the spindle pole body half bridge.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC31P067042EBI-2213082,EBI-4259

Protein-protein interaction databases

BioGridi31248, 94 interactors
DIPiDIP-8950N
IntActiQ12369, 23 interactors
MINTiQ12369
STRINGi4932.YLL003W

Structurei

Secondary structure

1946
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi222 – 240Combined sources19
Helixi241 – 245Combined sources5
Helixi247 – 294Combined sources48
Helixi643 – 675Combined sources33
Helixi677 – 706Combined sources30
Turni707 – 709Combined sources3

3D structure databases

ProteinModelPortaliQ12369
SMRiQ12369
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12369

Family & Domainsi

Sequence similaritiesi

Belongs to the SFI1 family.Curated

Phylogenomic databases

InParanoidiQ12369
OMAiRSIFDLW
OrthoDBiEOG092C37T9

Family and domain databases

InterProiView protein in InterPro
IPR013665 Sfi1_dom
IPR018907 Spindle_body_associated_C_dom
PfamiView protein in Pfam
PF08457 Sfi1, 2 hits
PF10638 Sfi1_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q12369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKFGTTNKS TENLLRDKFV PETSPTNIPT DVLIKQGQIT DSTESLIHGG
60 70 80 90 100
AERYIVNALK PIELNKTEGF FEDPPFHLPS PPVDSTNLEY EDVTDLPKNG
110 120 130 140 150
LRYDLNDISV EVIEDLYRQI EAFLVHFKLS RSFLQIFKNY VNILIQEGIN
160 170 180 190 200
PLRDEYFTIL EDELKGFFTF NSVIEEILEI FLIHPRNKFI ALSLAEYTYA
210 220 230 240 250
KNKIRRHFNH WKTVCELNEE ANRFANQAKL RVQEAVFYIW SDKTLKYSQM
260 270 280 290 300
ANDEAESFRN TWLLFRSFQQ WITLTQTLKE QSRLADQAFL NKMFRKILKA
310 320 330 340 350
QEHWKHLETV NTDNIKKIFL RTTFHIWKLR HKEINYHGLE RRIFERIKQK
360 370 380 390 400
VINYEYNKSI AEKVRSFSLQ RKYLNKWEKK NIENEDKLGA LYELENKFIK
410 420 430 440 450
QKFFRKLNRS FQHSQQEAIA KSKLNQTLLR CVFEKMWLKR FEDHLHLYSI
460 470 480 490 500
VSLKEANLVK RIFHSWKKLL YIDLKASDYS RTNLLKSSLR SWKLEVKLKI
510 520 530 540 550
FEQKCKKSIQ ASAYRTWRKR IQYGKISSEH VKTAFCAKYL GVWKRRMLQM
560 570 580 590 600
NSMNDEASKF YEEGLVNECL AIWKERLIKT KELEDRYNFL CKTHAILTVK
610 620 630 640 650
RTLMHIDNVH LLYTKLAPSM DRVKLSKAFL KWRKATRFKV RHKLNDILHV
660 670 680 690 700
YEKSKERELQ SQLFNAWRNR FCFYTEECNI QAISKRNYQL EKMVLKKFRE
710 720 730 740 750
RLLEIVKSEE LADEVREEFV LVKTFYIWKT HLDEIFYMST LLEQSEANKQ
760 770 780 790 800
FIITSKFLKM WSLRFLKIKR NDETVEVFRH RWDRATVRGL LLLWKNRSDS
810 820 830 840 850
SPKRRKDFNL KHELKTPIRS DSQNASTIPG SERIKQHRME AMKSHYSRAR
860 870 880 890 900
RAIPSPVKSS SVLDSTAKKQ INLESTTGLN GSPTRGKPLR YSPRRTTRNM
910 920 930 940
PSKVDHIDFG RIPAVPFSLS ANSPKIDQDM DYIREHDKSP LSRKRQ
Length:946
Mass (Da):112,979
Last modified:November 1, 1996 - v1
Checksum:iB58B966607801618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91488 Genomic DNA Translation: CAA62767.1
X95569 Genomic DNA Translation: CAA64815.1
Z73108 Genomic DNA Translation: CAA97446.1
BK006945 Genomic DNA Translation: DAA09316.1
PIRiS64745
RefSeqiNP_013098.1, NM_001181823.1

Genome annotation databases

EnsemblFungiiYLL003W; YLL003W; YLL003W
GeneIDi850657
KEGGisce:YLL003W

Similar proteinsi

Entry informationi

Entry nameiSFI1_YEAST
AccessioniPrimary (citable) accession number: Q12369
Secondary accession number(s): D6VY00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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