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Protein

Alpha-ketoglutarate-dependent sulfonate dioxygenase

Gene

JLP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate.1 Publication

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Pathwayi: alkanesulfonate degradation

This protein is involved in the pathway alkanesulfonate degradation, which is part of Organosulfur degradation.
View all proteins of this organism that are known to be involved in the pathway alkanesulfonate degradation and in Organosulfur degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi218Iron; catalyticBy similarity1
Metal bindingi220Iron; catalyticBy similarity1
Binding sitei2452-oxoglutarateBy similarity1
Binding sitei3522-oxoglutarateBy similarity1
Metal bindingi367Iron; catalyticBy similarity1
Binding sitei3792-oxoglutarateBy similarity1
Binding sitei3832-oxoglutarateBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sulfonate dioxygenase activity Source: SGD
  • taurine dioxygenase activity Source: GO_Central

GO - Biological processi

  • alkanesulfonate catabolic process Source: UniProtKB-UniPathway
  • sulfur compound catabolic process Source: SGD

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32156-MONOMER
UniPathwayiUPA00338

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-ketoglutarate-dependent sulfonate dioxygenase (EC:1.14.11.-)
Gene namesi
Name:JLP1
Ordered Locus Names:YLL057C
ORF Names:L0572
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL057C
SGDiS000003980 JLP1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940221 – 412Alpha-ketoglutarate-dependent sulfonate dioxygenaseAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ12358
PRIDEiQ12358

PTM databases

iPTMnetiQ12358

Interactioni

Protein-protein interaction databases

BioGridi31258, 49 interactors
DIPiDIP-1933N
IntActiQ12358, 7 interactors
MINTiQ12358
STRINGi4932.YLL057C

Structurei

3D structure databases

ProteinModelPortaliQ12358
SMRiQ12358
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TfdA dioxygenase family.Curated

Phylogenomic databases

HOGENOMiHOG000165073
InParanoidiQ12358
KOiK19245
OMAiQYLYRQA
OrthoDBiEOG092C2QNA

Family and domain databases

InterProiView protein in InterPro
IPR003819 TauD/TfdA-like
PfamiView protein in Pfam
PF02668 TauD, 1 hit

Sequencei

Sequence statusi: Complete.

Q12358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAAAQTAI PLPSTDLPVK IITNGLKNLN YTSKQGYGNF DTHFYDGQDE
60 70 80 90 100
VSPSGLLKIR KSYREKSKYP DYLPTWDPTE KYGPLEFHEY HDPALRADGN
110 120 130 140 150
FSNLFAKENV GQLKVKKITP KLGLEINGIQ LTDLSDAAKD ELALLVAQKG
160 170 180 190 200
VVVFRNQNFA DEGPDYVTEY GRHFGKLHIH QTSGHPQNNP ELHITFRRPD
210 220 230 240 250
AEEFARVFDD STSSGGWHTD VSYELQPPSY TFFSVVEGPD GGGDTLFADT
260 270 280 290 300
IEAFDRLSKP LQDFLSTLHV IHSSKEQAEN SQRQGGIKRR APVTHIHPLV
310 320 330 340 350
RVHPVLKKKC LYVNRAFSRK IVELKRQESE SLLNFLYNLV ESSHDLQLRA
360 370 380 390 400
KWEPHSVVIW DNRRVQHSAV IDWEEPIHRH AFRITPQAER PVEDLKFLND
410
ENYYPSSLTL DI
Length:412
Mass (Da):46,983
Last modified:November 1, 1996 - v1
Checksum:iF1BB8588B56CEEBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47973 Genomic DNA Translation: CAA88000.1
Z73162 Genomic DNA Translation: CAA97510.1
AY692737 Genomic DNA Translation: AAT92756.1
BK006945 Genomic DNA Translation: DAA09267.1
PIRiS50963
RefSeqiNP_013043.1, NM_001181877.1

Genome annotation databases

EnsemblFungiiYLL057C; YLL057C; YLL057C
GeneIDi850669
KEGGisce:YLL057C

Similar proteinsi

Entry informationi

Entry nameiJLP1_YEAST
AccessioniPrimary (citable) accession number: Q12358
Secondary accession number(s): D6VXV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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