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Protein

ATP synthase subunit H, mitochondrial

Gene

ATP14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

Miscellaneous

Present with 6140 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • ATP hydrolysis coupled cation transmembrane transport Source: GOC
  • ATP synthesis coupled proton transport Source: SGD
  • cristae formation Source: SGD
  • mitochondrial proton-transporting ATP synthase complex assembly Source: SGD

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32389-MONOMER

Protein family/group databases

MoonDBiQ12349 Predicted
TCDBi3.A.2.1.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit H, mitochondrial
Gene namesi
Name:ATP14
Ordered Locus Names:YLR295C
ORF Names:L8003.20
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

SGDiS000004286 ATP14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionAdd BLAST32
ChainiPRO_000000252533 – 124ATP synthase subunit H, mitochondrialAdd BLAST92

Proteomic databases

MaxQBiQ12349
PaxDbiQ12349
PRIDEiQ12349

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.

Protein-protein interaction databases

BioGridi31560, 146 interactors
ComplexPortaliCPX-3281 Mitochondrial proton-transporting ATP synthase complex
DIPiDIP-3030N
IntActiQ12349, 1 interactor
MINTiQ12349
STRINGi4932.YLR295C

Structurei

3D structure databases

ProteinModelPortaliQ12349
SMRiQ12349
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase h subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000197149
InParanoidiQ12349
KOiK02141
OMAiDYEASEV
OrthoDBiEOG092C5QZ2

Family and domain databases

InterProiView protein in InterPro
IPR019711 ATP_synth_F0_suH
PANTHERiPTHR28207 PTHR28207, 1 hit
PfamiView protein in Pfam
PF10775 ATP_sub_h, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12349-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPIASRRIL LNASVLPLRL CNRNFTTTRI SYNVIQDLYL RELKDTKLAP
60 70 80 90 100
STLQDAEGNV KPWNPPQKPN LPELELQGPE ALKAYTEQNV ETAHVAKESE
110 120
EGESEPIEED WLVLDDAEET KESH
Length:124
Mass (Da):14,128
Last modified:November 1, 1996 - v1
Checksum:i7AE196CFB250ACBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51673 Genomic DNA Translation: AAC49436.1
U17243 Genomic DNA Translation: AAB67340.1
AY558215 Genomic DNA Translation: AAS56541.1
BK006945 Genomic DNA Translation: DAA09606.1
PIRiS50379
RefSeqiNP_013398.1, NM_001182183.1

Genome annotation databases

EnsemblFungiiYLR295C; YLR295C; YLR295C
GeneIDi851002
KEGGisce:YLR295C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51673 Genomic DNA Translation: AAC49436.1
U17243 Genomic DNA Translation: AAB67340.1
AY558215 Genomic DNA Translation: AAS56541.1
BK006945 Genomic DNA Translation: DAA09606.1
PIRiS50379
RefSeqiNP_013398.1, NM_001182183.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CP3electron microscopy3.80633-124[»]
6CP6electron microscopy3.60633-124[»]
ProteinModelPortaliQ12349
SMRiQ12349
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31560, 146 interactors
ComplexPortaliCPX-3281 Mitochondrial proton-transporting ATP synthase complex
DIPiDIP-3030N
IntActiQ12349, 1 interactor
MINTiQ12349
STRINGi4932.YLR295C

Protein family/group databases

MoonDBiQ12349 Predicted
TCDBi3.A.2.1.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Proteomic databases

MaxQBiQ12349
PaxDbiQ12349
PRIDEiQ12349

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR295C; YLR295C; YLR295C
GeneIDi851002
KEGGisce:YLR295C

Organism-specific databases

SGDiS000004286 ATP14

Phylogenomic databases

HOGENOMiHOG000197149
InParanoidiQ12349
KOiK02141
OMAiDYEASEV
OrthoDBiEOG092C5QZ2

Enzyme and pathway databases

BioCyciYEAST:G3O-32389-MONOMER

Miscellaneous databases

PROiPR:Q12349

Family and domain databases

InterProiView protein in InterPro
IPR019711 ATP_synth_F0_suH
PANTHERiPTHR28207 PTHR28207, 1 hit
PfamiView protein in Pfam
PF10775 ATP_sub_h, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATP14_YEAST
AccessioniPrimary (citable) accession number: Q12349
Secondary accession number(s): D6VYU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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