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Entry version 166 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Sulfate permease 2

Gene

SUL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity uptake of sulfate into the cell.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.1.13, the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfate permease 2
Alternative name(s):
High-affinity sulfate transporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUL2
Synonyms:SEL2
Ordered Locus Names:YLR092W
ORF Names:L9449.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004082, SUL2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YLR092W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 131CytoplasmicSequence analysisAdd BLAST131
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 163ExtracellularSequence analysisAdd BLAST11
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 188CytoplasmicSequence analysis4
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 221ExtracellularSequence analysisAdd BLAST12
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 244CytoplasmicSequence analysis2
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 305ExtracellularSequence analysisAdd BLAST40
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 350CytoplasmicSequence analysisAdd BLAST24
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 399ExtracellularSequence analysisAdd BLAST28
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 443CytoplasmicSequence analysisAdd BLAST23
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 483ExtracellularSequence analysisAdd BLAST19
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 532CytoplasmicSequence analysisAdd BLAST28
Transmembranei533 – 551HelicalSequence analysisAdd BLAST19
Topological domaini552 – 559ExtracellularSequence analysis8
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 893CytoplasmicSequence analysisAdd BLAST313

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000801851 – 893Sulfate permease 2Add BLAST893

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12325

PRoteomics IDEntifications database

More...
PRIDEi
Q12325

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q12325

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31365, 81 interactors

Database of interacting proteins

More...
DIPi
DIP-5082N

Protein interaction database and analysis system

More...
IntActi
Q12325, 4 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YLR092W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12325, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini676 – 854STASPROSITE-ProRule annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234512

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003182_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12325

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTPFFHF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018045, S04_transporter_CS
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814, PTHR11814, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00916, Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52091, SSF52091, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00815, sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01130, SLC26A, 1 hit
PS50801, STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSREGYPNFE EVEIPDFQET NNTVPDLDDL ELEYDQYKNN ENNDTFNDKD
60 70 80 90 100
LESNSVAKHN AVNSSKGVKG SKIDYFNPSD VSLYDNSVSQ FEETTVSLKE
110 120 130 140 150
YYDHSIRSHL TVKGACSYLK SVFPIINWLP HYNFSWFTAD LIAGITIGCV
160 170 180 190 200
LVPQSMSYAQ VATLPAQYGL YSSFIGAYSY SFFATSKDVC IGPVAVMSLQ
210 220 230 240 250
TAKVIADVTA KYPDGDSAIT GPVIATTLAL LCGIISAAVG FLRLGFLVEL
260 270 280 290 300
ISLNAVAGFM TGSAFNILWG QVPALMGYNS LVNTRAATYK VVIETLKHLP
310 320 330 340 350
DTKLDAVFGL IPLFLLYVWK WWCGTYGPRL NDRYNSKNPR LHKIIKWTYF
360 370 380 390 400
YAQASRNGII IIVFTCIGWA ITRGKSKSER PISILGSVPS GLKEVGVFHV
410 420 430 440 450
PPGLMSKLGP NLPASIIVLL LEHIAISKSF GRINDYKVVP DQELIAIGVS
460 470 480 490 500
NLLGTFFNAY PATGSFSRSA LKAKCNVRTP LSGLFSGSCV LLALYCLTGA
510 520 530 540 550
FFYIPKATLS AVIIHAVSDL LASYQTTWNF WKMNPLDFIC FIVTVLITVF
560 570 580 590 600
ASIEDGIYFA MCWSCAMLIL KVAFPAGKFL GRVEVAEVTD AYVRPDSDVV
610 620 630 640 650
SYVSENNNGI STLEDGGEDD KESSTKYVTN SSKKIETNVQ TKGFDSPSSS
660 670 680 690 700
ISQPRIKYHT KWIPFDHKYT RELNPDVQIL PPPDGVLVYR LSESYTYLNC
710 720 730 740 750
SRHYNIITEE VKKVTRRGQL IRHRKKSDRP WNDPGPWEAP AFLKNLKFWK
760 770 780 790 800
KRENDPESME NAPSTSVDVE RDDRPLLKIL CLDFSQVAQT DATALQSLVD
810 820 830 840 850
LRKAINQYAD RQVEFHFVGI ISPWVKRGLI SRGFGTLNEE YSDESIVAGH
860 870 880 890
TSYHVARVPQ GEENPEKYSV YTASGTNLPF FHIDIPDFAK WDI
Length:893
Mass (Da):99,651
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67826955AC7C0BF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U53880 Genomic DNA Translation: AAB67596.1
Z73264 Genomic DNA Translation: CAA97653.1
Z73265 Genomic DNA Translation: CAA97655.1
U53876 Genomic DNA Translation: AAB67550.1
BK006945 Genomic DNA Translation: DAA09408.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64926

NCBI Reference Sequences

More...
RefSeqi
NP_013193.1, NM_001181979.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR092W_mRNA; YLR092W; YLR092W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR092W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53880 Genomic DNA Translation: AAB67596.1
Z73264 Genomic DNA Translation: CAA97653.1
Z73265 Genomic DNA Translation: CAA97655.1
U53876 Genomic DNA Translation: AAB67550.1
BK006945 Genomic DNA Translation: DAA09408.1
PIRiS64926
RefSeqiNP_013193.1, NM_001181979.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31365, 81 interactors
DIPiDIP-5082N
IntActiQ12325, 4 interactors
STRINGi4932.YLR092W

Protein family/group databases

TCDBi2.A.53.1.13, the sulfate permease (sulp) family

Proteomic databases

PaxDbiQ12325
PRIDEiQ12325
TopDownProteomicsiQ12325

Genome annotation databases

EnsemblFungiiYLR092W_mRNA; YLR092W; YLR092W
GeneIDi850781
KEGGisce:YLR092W

Organism-specific databases

SGDiS000004082, SUL2
VEuPathDBiFungiDB:YLR092W

Phylogenomic databases

eggNOGiKOG0236, Eukaryota
GeneTreeiENSGT01030000234512
HOGENOMiCLU_003182_8_1_1
InParanoidiQ12325
OMAiDTPFFHF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12325
RNActiQ12325, protein

Family and domain databases

InterProiView protein in InterPro
IPR018045, S04_transporter_CS
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf
PANTHERiPTHR11814, PTHR11814, 1 hit
PfamiView protein in Pfam
PF00916, Sulfate_transp, 1 hit
SUPFAMiSSF52091, SSF52091, 1 hit
TIGRFAMsiTIGR00815, sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130, SLC26A, 1 hit
PS50801, STAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUL2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12325
Secondary accession number(s): D6VY92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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