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Protein

Ubiquitin-like protein SMT3

Gene

SMT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not known; suppressor of MIF2 mutations.

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein tag Source: SGD

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-30030-MONOMER
ReactomeiR-SCE-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-SCE-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-SCE-3065679 SUMO is proteolytically processed
R-SCE-3108214 SUMOylation of DNA damage response and repair proteins
R-SCE-3899300 SUMOylation of transcription cofactors
R-SCE-4085377 SUMOylation of SUMOylation proteins
R-SCE-4551638 SUMOylation of chromatin organization proteins
R-SCE-4570464 SUMOylation of RNA binding proteins
R-SCE-4615885 SUMOylation of DNA replication proteins
R-SCE-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SCE-5696395 Formation of Incision Complex in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein SMT3
Gene namesi
Name:SMT3
Ordered Locus Names:YDR510W
ORF Names:D9719.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002918 SMT3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000359632 – 98Ubiquitin-like protein SMT3Add BLAST97
PropeptideiPRO_000003596499 – 1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Cross-linki98Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein

Proteomic databases

MaxQBiQ12306
PaxDbiQ12306
PRIDEiQ12306

PTM databases

iPTMnetiQ12306

Miscellaneous databases

PMAP-CutDBiQ12306

Interactioni

Subunit structurei

Activated by a E1 ligase composed of AOS1 and UBA2.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32561, 709 interactors
DIPiDIP-1364N
IntActiQ12306, 79 interactors
MINTiQ12306
STRINGi4932.YDR510W

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ12306
SMRiQ12306
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12306

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 98Ubiquitin-likePROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000018808
HOGENOMiHOG000207495
InParanoidiQ12306
KOiK12160
OMAiNDTIDVM
OrthoDBiEOG092C5C59

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12306-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSEVNQEA KPEVKPEVKP ETHINLKVSD GSSEIFFKIK KTTPLRRLME
60 70 80 90 100
AFAKRQGKEM DSLRFLYDGI RIQADQTPED LDMEDNDIIE AHREQIGGAT

Y
Length:101
Mass (Da):11,597
Last modified:November 1, 1996 - v1
Checksum:iA2790DE7F315E1A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27233 Genomic DNA Translation: AAB01675.1
U33057 Genomic DNA Translation: AAB64951.1
AY558174 Genomic DNA Translation: AAS56500.1
BK006938 Genomic DNA Translation: DAA12341.1
PIRiS63999
RefSeqiNP_010798.1, NM_001180818.1

Genome annotation databases

EnsemblFungiiYDR510W; YDR510W; YDR510W
GeneIDi852122
KEGGisce:YDR510W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27233 Genomic DNA Translation: AAB01675.1
U33057 Genomic DNA Translation: AAB64951.1
AY558174 Genomic DNA Translation: AAS56500.1
BK006938 Genomic DNA Translation: DAA12341.1
PIRiS63999
RefSeqiNP_010798.1, NM_001180818.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EUVX-ray1.60B13-98[»]
1L2NNMR-A1-101[»]
2EKEX-ray1.90C/D13-98[»]
3PGEX-ray2.80A1-98[»]
3QHTX-ray2.40A/B2-98[»]
3TIXX-ray2.90A/C1-98[»]
3UF8X-ray1.50A13-98[»]
3UQAX-ray1.55A13-98[»]
3UQBX-ray1.90A13-98[»]
3V60X-ray2.60A20-98[»]
3V61X-ray2.80A20-98[»]
3V62X-ray2.90A/D20-98[»]
3VAWX-ray1.55A13-98[»]
4FN2X-ray1.95A/B13-98[»]
4G50X-ray1.75A/B13-98[»]
4GGQX-ray1.95A/B/C/D13-98[»]
4GIVX-ray2.45A/B13-98[»]
5D6JX-ray2.25B21-94[»]
5JNEX-ray2.85A/E20-98[»]
C/G19-98[»]
5KLXX-ray2.45A/B/C/D13-98[»]
5V8TX-ray2.10A/B13-97[»]
6CFPX-ray2.45A13-98[»]
ProteinModelPortaliQ12306
SMRiQ12306
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32561, 709 interactors
DIPiDIP-1364N
IntActiQ12306, 79 interactors
MINTiQ12306
STRINGi4932.YDR510W

PTM databases

iPTMnetiQ12306

Proteomic databases

MaxQBiQ12306
PaxDbiQ12306
PRIDEiQ12306

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR510W; YDR510W; YDR510W
GeneIDi852122
KEGGisce:YDR510W

Organism-specific databases

SGDiS000002918 SMT3

Phylogenomic databases

GeneTreeiENSGT00390000018808
HOGENOMiHOG000207495
InParanoidiQ12306
KOiK12160
OMAiNDTIDVM
OrthoDBiEOG092C5C59

Enzyme and pathway databases

BioCyciYEAST:G3O-30030-MONOMER
ReactomeiR-SCE-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-SCE-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-SCE-3065679 SUMO is proteolytically processed
R-SCE-3108214 SUMOylation of DNA damage response and repair proteins
R-SCE-3899300 SUMOylation of transcription cofactors
R-SCE-4085377 SUMOylation of SUMOylation proteins
R-SCE-4551638 SUMOylation of chromatin organization proteins
R-SCE-4570464 SUMOylation of RNA binding proteins
R-SCE-4615885 SUMOylation of DNA replication proteins
R-SCE-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SCE-5696395 Formation of Incision Complex in GG-NER

Miscellaneous databases

EvolutionaryTraceiQ12306
PMAP-CutDBiQ12306
PROiPR:Q12306

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMT3_YEAST
AccessioniPrimary (citable) accession number: Q12306
Secondary accession number(s): D6VTD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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