Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High-affinity glucose transporter RGT2

Gene

RGT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Low-affinity glucose transporter. Can function as a sensor that generates an intracellular signal in the presence of high level of glucose. Required for maximal expression of the high glucose-induced HXT1 protein.

GO - Molecular functioni

GO - Biological processi

  • detection of glucose Source: SGD
  • glucose mediated signaling pathway Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29537-MONOMER

Protein family/group databases

TCDBi2.A.1.1.19 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter RGT2
Gene namesi
Name:RGT2
Ordered Locus Names:YDL138W
ORF Names:D2160
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL138W
SGDiS000002297 RGT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 99CytoplasmicSequence analysisAdd BLAST99
Transmembranei100 – 120Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini121 – 144ExtracellularSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini166 – 175CytoplasmicSequence analysis10
Transmembranei176 – 196Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini197ExtracellularSequence analysis1
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini219 – 231CytoplasmicSequence analysisAdd BLAST13
Transmembranei232 – 252Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini253 – 266ExtracellularSequence analysisAdd BLAST14
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini288 – 357CytoplasmicSequence analysisAdd BLAST70
Transmembranei358 – 378Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini379 – 393ExtracellularSequence analysisAdd BLAST15
Transmembranei394 – 414Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini415 – 421CytoplasmicSequence analysis7
Transmembranei422 – 442Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini443 – 452ExtracellularSequence analysis10
Transmembranei453 – 473Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini474 – 491CytoplasmicSequence analysisAdd BLAST18
Transmembranei492 – 512Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini513 – 524ExtracellularSequence analysisAdd BLAST12
Transmembranei525 – 545Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini546 – 763CytoplasmicSequence analysisAdd BLAST218

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi231R → K in RGT2-1; constitutively signaling glucose receptor. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503891 – 763High-affinity glucose transporter RGT2Add BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ12300
PRIDEiQ12300

Interactioni

Protein-protein interaction databases

BioGridi31923, 181 interactors
DIPiDIP-2865N
IntActiQ12300, 20 interactors
MINTiQ12300
STRINGi4932.YDL138W

Structurei

3D structure databases

ProteinModelPortaliQ12300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149265
HOGENOMiHOG000202870
InParanoidiQ12300
KOiK08139
OMAiCSGINFI
OrthoDBiEOG092C1Q5W

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR037792 Rgt2/Snf3
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PANTHERiPTHR23500:SF343 PTHR23500:SF343, 1 hit
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q12300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDSQNCLRQ REENSHLNPG NDFGHHQGAE CTINHNNMPH RNAYTESTND
60 70 80 90 100
TEAKSIVMCD DPNAYQISYT NNEPAGDGAI ETTSILLSQP LPLRSNVMSV
110 120 130 140 150
LVGIFVAVGG FLFGYDTGLI NSITDMPYVK TYIAPNHSYF TTSQIAILVS
160 170 180 190 200
FLSLGTFFGA LIAPYISDSY GRKPTIMFST AVIFSIGNSL QVASGGLVLL
210 220 230 240 250
IVGRVISGIG IGIISAVVPL YQAEAAQKNL RGAIISSYQW AITIGLLVSS
260 270 280 290 300
AVSQGTHSKN GPSSYRIPIG LQYVWSSILA VGMIFLPESP RYYVLKDELN
310 320 330 340 350
KAAKSLSFLR GLPIEDPRLL EELVEIKATY DYEASFGPST LLDCFKTSEN
360 370 380 390 400
RPKQILRIFT GIAIQAFQQA SGINFIFYYG VNFFNNTGVD NSYLVSFISY
410 420 430 440 450
AVNVAFSIPG MYLVDRIGRR PVLLAGGVIM AIANLVIAIV GVSEGKTVVA
460 470 480 490 500
SKIMIAFICL FIAAFSATWG GVVWVVSAEL YPLGVRSKCT AICAAANWLV
510 520 530 540 550
NFTCALITPY IVDVGSHTSS MGPKIFFIWG GLNVVAVIVV YFAVYETRGL
560 570 580 590 600
TLEEIDELFR KAPNSVISSK WNKKIRKRCL AFPISQQIEM KTNIKNAGKL
610 620 630 640 650
DNNNSPIVQD DSHNIIDVDG FLENQIQSND HMIAADKGSG SLVNIIDTAP
660 670 680 690 700
LTSTEFKPVE HPPVNYVDLG NGLGLNTYNR GPPSIISDST DEFYEENDSS
710 720 730 740 750
YYNNNTERNG ANSVNTYMAQ LINSSSTTSN DTSFSPSHNS NARTSSNWTS
760
DLASKHSQYT SPQ
Length:763
Mass (Da):83,159
Last modified:November 1, 1997 - v1
Checksum:iDF6E2F1C337F106E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96876 Genomic DNA Translation: CAA65621.1
Z74186 Genomic DNA Translation: CAA98711.1
BK006938 Genomic DNA Translation: DAA11720.1
PIRiS67684
RefSeqiNP_010143.1, NM_001180198.1

Genome annotation databases

EnsemblFungiiYDL138W; YDL138W; YDL138W
GeneIDi851417
KEGGisce:YDL138W

Similar proteinsi

Entry informationi

Entry nameiRGT2_YEAST
AccessioniPrimary (citable) accession number: Q12300
Secondary accession number(s): D6VRL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again