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Protein

25S rRNA (uridine(2843)-N(3))-methyltransferase

Gene

BMT6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N3 position of uridine 2843 (m3U2843) in 25S rRNA.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + uracil(2843) in 25S rRNA = S-adenosyl-L-homocysteine + N3-methyluracil(2843) in 25S rRNA.1 Publication

GO - Molecular functioni

  • rRNA (uridine-N3-)-methyltransferase activity Source: SGD
  • S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  • rRNA base methylation Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32216-MONOMER
YEAST:G3O-32216-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
25S rRNA (uridine(2843)-N(3))-methyltransferase (EC:2.1.1.3121 Publication)
Alternative name(s):
Base methyltransferase of 25S RNA 6
Gene namesi
Name:BMT6
Ordered Locus Names:YLR063W
ORF Names:L2174
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR063W
SGDiS000004053 BMT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi294G → R: Abolishes methyltransferase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472301 – 36525S rRNA (uridine(2843)-N(3))-methyltransferaseAdd BLAST365

Proteomic databases

MaxQBiQ12291
PaxDbiQ12291
PRIDEiQ12291

Interactioni

Protein-protein interaction databases

BioGridi31337, 56 interactors
DIPiDIP-4828N
IntActiQ12291, 5 interactors
STRINGi4932.YLR063W

Structurei

3D structure databases

ProteinModelPortaliQ12291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000001109
InParanoidiQ12291
KOiK19308
OMAiENMRFFY
OrthoDBiEOG092C2HUZ

Family and domain databases

InterProiView protein in InterPro
IPR021463 Methyltransf_34
PfamiView protein in Pfam
PF11312 Methyltransf_34, 1 hit

Sequencei

Sequence statusi: Complete.

Q12291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLMRRFAFL TSSVYFKYIP IYSQYHYSSQ FPINMNPKKV AQLPVHNKST
60 70 80 90 100
LPPQEIIDLF KITFLEELYP KDQDNEKSPL TEQIQAVKSD LYNRDYNAAF
110 120 130 140 150
NNDSKRIAYC CRWSPSRATS YASVFAHFPE LLKIIRCEID DKDSNVLCIG
160 170 180 190 200
GGAGGELVAL ASIFTLSRDF SSKFASALKI DNEVNKKPRN LNIQLVDIAD
210 220 230 240 250
WSTVVEKLTA TIKSKWLYGD SEAESFNVNF THKDCLQMTE PQDIKIYQGL
260 270 280 290 300
DLITLLFTTN ELFTQKKVES IKFLQRLNEN CAPGCHLLIL ESAGSYSHIT
310 320 330 340 350
INNKKFPIQF LIDTILVGNR KDKGTTGPWS LVSENDSIWY RMDPKLDYSI
360
PLENMRFFYR LYVKN
Length:365
Mass (Da):42,041
Last modified:November 1, 1996 - v1
Checksum:iA072FB00FD3A110C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94607 Genomic DNA Translation: CAA64309.1
Z73235 Genomic DNA Translation: CAA97619.1
BK006945 Genomic DNA Translation: DAA09380.1
PIRiS61636
RefSeqiNP_013164.1, NM_001181950.1

Genome annotation databases

EnsemblFungiiYLR063W; YLR063W; YLR063W
GeneIDi850752
KEGGisce:YLR063W

Similar proteinsi

Entry informationi

Entry nameiBMT6_YEAST
AccessioniPrimary (citable) accession number: Q12291
Secondary accession number(s): D6VY64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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