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UniProtKB - Q12270 (RBD2_YEAST)
Protein
Rhomboid protein 2
Gene
RBD2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Probable serine protease.
By similarityMiscellaneous
Present with 7850 molecules/cell in log phase SD medium.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 124 | NucleophileBy similarity | 1 | |
Active sitei | 179 | By similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RBD2 Ordered Locus Names:YPL246C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006167, RBD2 |
VEuPathDBi | FungiDB:YPL246C |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
- cis-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus Source: SGD
- Golgi membrane Source: UniProtKB-SubCell
Nucleus
- nuclear periphery Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 38 – 57 | LumenalSequence analysisAdd BLAST | 20 | |
Transmembranei | 58 – 78 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 89 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 112 | LumenalSequence analysis | 2 | |
Transmembranei | 113 – 133 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 151 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 152 – 168 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 169 – 174 | LumenalSequence analysis | 6 | |
Transmembranei | 175 – 191 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 192 – 262 | CytoplasmicSequence analysisAdd BLAST | 71 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206193 | 1 – 262 | Rhomboid protein 2Add BLAST | 262 |
Proteomic databases
MaxQBi | Q12270 |
PaxDbi | Q12270 |
PRIDEi | Q12270 |
TopDownProteomicsi | Q12270 |
Interactioni
Subunit structurei
Interacts with SNX3.
1 PublicationBinary interactionsi
Q12270
With | #Exp. | IntAct |
---|---|---|
VAM7 [P32912] | 3 | EBI-31471,EBI-20232 |
Protein-protein interaction databases
BioGRIDi | 35917, 124 interactors |
DIPi | DIP-1734N |
IntActi | Q12270, 47 interactors |
MINTi | Q12270 |
STRINGi | 4932.YPL246C |
Miscellaneous databases
RNActi | Q12270, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 243 – 262 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 247 – 262 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the peptidase S54 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2632, Eukaryota |
HOGENOMi | CLU_071084_0_0_1 |
InParanoidi | Q12270 |
OMAi | TFPLIHL |
Family and domain databases
Gene3Di | 1.20.1540.10, 1 hit |
InterProi | View protein in InterPro IPR022764, Peptidase_S54_rhomboid_dom IPR035952, Rhomboid-like_sf |
Pfami | View protein in Pfam PF01694, Rhomboid, 1 hit |
SUPFAMi | SSF144091, SSF144091, 1 hit |
i Sequence
Sequence statusi: Complete.
Q12270-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNWKSYVFPG GHPPAALTTG LVVFLTAIYL LSFIFALRED LSLAPESLFK
60 70 80 90 100
LQMSRLSLYP LIHLSLPHLL FNVLAIWAPL NLFEETHGTV YTGVFLNLSA
110 120 130 140 150
LFAGILYCLL GKLLYPEALV AGASGWCFTL FAYYSFKESQ IRPRTRIFRT
160 170 180 190 200
DYSIPTLYTP LVLLVAIAVV IPGSSFWGHF FGLCVGYAIG YKESWFNKIT
210 220 230 240 250
PPGWIITKIE KSLDGLIRLI PWGIKYYRDE DIDRTKDYEP LMSTETPLPL
260
HNDNSGTVLG TA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73602 Genomic DNA Translation: CAA97967.1 Z67751 Genomic DNA Translation: CAA91598.1 BK006949 Genomic DNA Translation: DAA11191.1 |
PIRi | S61018 |
RefSeqi | NP_015078.1, NM_001184060.1 |
Genome annotation databases
EnsemblFungii | YPL246C_mRNA; YPL246C; YPL246C |
GeneIDi | 855830 |
KEGGi | sce:YPL246C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73602 Genomic DNA Translation: CAA97967.1 Z67751 Genomic DNA Translation: CAA91598.1 BK006949 Genomic DNA Translation: DAA11191.1 |
PIRi | S61018 |
RefSeqi | NP_015078.1, NM_001184060.1 |
3D structure databases
SMRi | Q12270 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35917, 124 interactors |
DIPi | DIP-1734N |
IntActi | Q12270, 47 interactors |
MINTi | Q12270 |
STRINGi | 4932.YPL246C |
Proteomic databases
MaxQBi | Q12270 |
PaxDbi | Q12270 |
PRIDEi | Q12270 |
TopDownProteomicsi | Q12270 |
Genome annotation databases
EnsemblFungii | YPL246C_mRNA; YPL246C; YPL246C |
GeneIDi | 855830 |
KEGGi | sce:YPL246C |
Organism-specific databases
SGDi | S000006167, RBD2 |
VEuPathDBi | FungiDB:YPL246C |
Phylogenomic databases
eggNOGi | KOG2632, Eukaryota |
HOGENOMi | CLU_071084_0_0_1 |
InParanoidi | Q12270 |
OMAi | TFPLIHL |
Miscellaneous databases
PROi | PR:Q12270 |
RNActi | Q12270, protein |
Family and domain databases
Gene3Di | 1.20.1540.10, 1 hit |
InterProi | View protein in InterPro IPR022764, Peptidase_S54_rhomboid_dom IPR035952, Rhomboid-like_sf |
Pfami | View protein in Pfam PF01694, Rhomboid, 1 hit |
SUPFAMi | SSF144091, SSF144091, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RBD2_YEAST | |
Accessioni | Q12270Primary (citable) accession number: Q12270 Secondary accession number(s): D6W3C5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families