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Entry version 154 (07 Oct 2020)
Sequence version 2 (17 Oct 2006)
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Protein

Vacuolar v-SNARE NYV1

Gene

NYV1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Vacuolar v-SNARE required for docking. Only involved in homotypic vacuole fusion. Required for Ca2+ efflux from the vacuolar lumen, a required signal for subsequent membrane fusion events, by inhibiting vacuolar Ca2+-ATPase PMC1 and promoting Ca2+ release when forming trans-SNARE assemblies during the docking step.4 Publications

Miscellaneous

Present with 1885 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-199992, trans-Golgi Network Vesicle Budding
R-SCE-432722, Golgi Associated Vesicle Biogenesis

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.1.1.2, the synaptosomal vesicle fusion pore (svf-pore) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar v-SNARE NYV1
Short name:
R-SNARE NYV1
Alternative name(s):
New v-SNARE 1
Synaptobrevin NYV1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NYV1
Synonyms:MAM2
Ordered Locus Names:YLR093C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YLR093C

Saccharomyces Genome Database

More...
SGDi
S000004083, NYV1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 231CytoplasmicSequence analysisAdd BLAST231
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei232 – 252Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini253VacuolarSequence analysis1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002067801 – 253Vacuolar v-SNARE NYV1Add BLAST253

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12255

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12255

PRoteomics IDEntifications database

More...
PRIDEi
Q12255

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q12255

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12255

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present in a pentameric cis-SNARE complex composed of the v-SNAREs NYV1, VTI1 and YKT6, and the t-SNAREs VAM3 and VAM7 on vacuolar membranes.

Interacts in trans with the cognate t-SNARE VAM3 during the docking step of homotypic vacuolar fusion.

Interacts with the vacuolar transporter chaperone (VTC) complex and the vacuolar Ca2+-ATPase PMC1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31366, 80 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5401, Vacuolar SNARE complex VAM3-VTI1-VAM7-NYV1
CPX-5521, Vacuolar SNARE complex SSO1-SEC9-NYV1

Database of interacting proteins

More...
DIPi
DIP-2248N

Protein interaction database and analysis system

More...
IntActi
Q12255, 16 interactors

Molecular INTeraction database

More...
MINTi
Q12255

STRING: functional protein association networks

More...
STRINGi
4932.YLR093C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12255, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1253
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12255

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q12255

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 227v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0860, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1107824_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12255

KEGG Orthology (KO)

More...
KOi
K08564

Identification of Orthologs from Complete Genome Data

More...
OMAi
IDGYDCY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.450.230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038426, Nyv1_N
IPR001388, Synaptobrevin
IPR042855, V_SNARE_CC
IPR019005, Vacuolar_R-SNAR_Nyv1_N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09426, Nyv1_N, 1 hit
PF00957, Synaptobrevin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00219, SYNAPTOBREVN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50892, V_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12255-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRFNVSYVE VIKNGETISS CFQPFQKNEN YGTITSANEQ ITPVIFHNLI
60 70 80 90 100
MDMVLPKVVP IKGNKVTKMS MNLIDGFDCF YSTDDHDPKT VYVCFTLVDM
110 120 130 140 150
PKILPIRILS GLQEYESNAT NELLSSHVGQ ILDSFHEELV EYRNQTLNSS
160 170 180 190 200
GNGQSSNGNG QNTISDIGDA TEDQIKDVIQ IMNDNIDKFL ERQERVSLLV
210 220 230 240 250
DKTSQLNSSS NKFRRKAVNI KEIMWWQKVK NITLLTFTII LFVSAAFMFF

YLW
Length:253
Mass (Da):28,964
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i494B587CF0F85997
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB67537 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAT92805 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA97654 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z73265 Genomic DNA Translation: CAA97654.1 Sequence problems.
U53876 Genomic DNA Translation: AAB67537.1 Sequence problems.
AY692786 Genomic DNA Translation: AAT92805.1 Sequence problems.
BK006945 Genomic DNA Translation: DAA09409.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64927

NCBI Reference Sequences

More...
RefSeqi
NP_013194.2, NM_001181980.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR093C_mRNA; YLR093C; YLR093C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR093C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73265 Genomic DNA Translation: CAA97654.1 Sequence problems.
U53876 Genomic DNA Translation: AAB67537.1 Sequence problems.
AY692786 Genomic DNA Translation: AAT92805.1 Sequence problems.
BK006945 Genomic DNA Translation: DAA09409.1
PIRiS64927
RefSeqiNP_013194.2, NM_001181980.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FZ0NMR-A1-149[»]
SMRiQ12255
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31366, 80 interactors
ComplexPortaliCPX-5401, Vacuolar SNARE complex VAM3-VTI1-VAM7-NYV1
CPX-5521, Vacuolar SNARE complex SSO1-SEC9-NYV1
DIPiDIP-2248N
IntActiQ12255, 16 interactors
MINTiQ12255
STRINGi4932.YLR093C

Protein family/group databases

TCDBi1.F.1.1.2, the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetiQ12255

Proteomic databases

MaxQBiQ12255
PaxDbiQ12255
PRIDEiQ12255
TopDownProteomicsiQ12255

Genome annotation databases

EnsemblFungiiYLR093C_mRNA; YLR093C; YLR093C
GeneIDi850782
KEGGisce:YLR093C

Organism-specific databases

EuPathDBiFungiDB:YLR093C
SGDiS000004083, NYV1

Phylogenomic databases

eggNOGiKOG0860, Eukaryota
HOGENOMiCLU_1107824_0_0_1
InParanoidiQ12255
KOiK08564
OMAiIDGYDCY

Enzyme and pathway databases

ReactomeiR-SCE-199992, trans-Golgi Network Vesicle Budding
R-SCE-432722, Golgi Associated Vesicle Biogenesis

Miscellaneous databases

EvolutionaryTraceiQ12255

Protein Ontology

More...
PROi
PR:Q12255
RNActiQ12255, protein

Family and domain databases

Gene3Di3.30.450.230, 1 hit
InterProiView protein in InterPro
IPR038426, Nyv1_N
IPR001388, Synaptobrevin
IPR042855, V_SNARE_CC
IPR019005, Vacuolar_R-SNAR_Nyv1_N_dom
PfamiView protein in Pfam
PF09426, Nyv1_N, 1 hit
PF00957, Synaptobrevin, 1 hit
PRINTSiPR00219, SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS50892, V_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNYV1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12255
Secondary accession number(s): D6VY93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 17, 2006
Last modified: October 7, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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