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Protein

Proteasome chaperone 4

Gene

POC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Involved in maintenance of telomere length.3 Publications

Miscellaneous

Present with 2210 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: SGD
  • proteasome assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-34041-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome chaperone 4
Gene namesi
Name:POC4
Synonyms:DMP1
Ordered Locus Names:YPL144W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

SGDiS000006065 POC4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002386351 – 148Proteasome chaperone 4Add BLAST148

Proteomic databases

MaxQBiQ12245
PaxDbiQ12245
PRIDEiQ12245

Interactioni

Subunit structurei

Component of the 20S proteasome chaperone. Forms a heterodimer with IRC25 that binds to proteasome precursors. Interacts with POP2.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi36039, 331 interactors
DIPiDIP-8930N
IntActiQ12245, 11 interactors
MINTiQ12245
STRINGi4932.YPL144W

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ12245
SMRiQ12245
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12245

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG4 family.Curated

Phylogenomic databases

HOGENOMiHOG000115600
InParanoidiQ12245
KOiK11882
OMAiHMATIIS
OrthoDBiEOG092C5PA4

Family and domain databases

InterProiView protein in InterPro
IPR018854 Psome_chaperone_3/4
PfamiView protein in Pfam
PF10448 POC3_POC4, 1 hit

Sequencei

Sequence statusi: Complete.

Q12245-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVKTISRTI ESESGFLQPT LDVIATLPAD DRSKKIPISL VVGFKQEASL
60 70 80 90 100
NSSSSLSCYY YAIPLMRDRH INLKSGGSNV VGIPLLDTKD DRIRDMARHM
110 120 130 140
ATIISERFNR PCYVTWSSLP SEDPSMLVAN HLYILKKCLD LLKTELGE
Length:148
Mass (Da):16,573
Last modified:November 1, 1996 - v1
Checksum:i1CC7C6074CF4AC08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9T → P in AAS56461 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA Translation: CAA65549.1
U43703 Genomic DNA Translation: AAB68232.1
Z73500 Genomic DNA Translation: CAA97848.1
AY558135 Genomic DNA Translation: AAS56461.1
BK006949 Genomic DNA Translation: DAA11291.1
PIRiS65155
RefSeqiNP_015181.1, NM_001183958.1

Genome annotation databases

EnsemblFungiiYPL144W; YPL144W; YPL144W
GeneIDi855959
KEGGisce:YPL144W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA Translation: CAA65549.1
U43703 Genomic DNA Translation: AAB68232.1
Z73500 Genomic DNA Translation: CAA97848.1
AY558135 Genomic DNA Translation: AAS56461.1
BK006949 Genomic DNA Translation: DAA11291.1
PIRiS65155
RefSeqiNP_015181.1, NM_001183958.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96A1-148[»]
2Z5CX-ray2.90A/D1-148[»]
ProteinModelPortaliQ12245
SMRiQ12245
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36039, 331 interactors
DIPiDIP-8930N
IntActiQ12245, 11 interactors
MINTiQ12245
STRINGi4932.YPL144W

Proteomic databases

MaxQBiQ12245
PaxDbiQ12245
PRIDEiQ12245

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL144W; YPL144W; YPL144W
GeneIDi855959
KEGGisce:YPL144W

Organism-specific databases

SGDiS000006065 POC4

Phylogenomic databases

HOGENOMiHOG000115600
InParanoidiQ12245
KOiK11882
OMAiHMATIIS
OrthoDBiEOG092C5PA4

Enzyme and pathway databases

BioCyciYEAST:G3O-34041-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ12245
PROiPR:Q12245

Family and domain databases

InterProiView protein in InterPro
IPR018854 Psome_chaperone_3/4
PfamiView protein in Pfam
PF10448 POC3_POC4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOC4_YEAST
AccessioniPrimary (citable) accession number: Q12245
Secondary accession number(s): D6W3M5, Q6Q5F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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