UniProtKB - Q12233 (ATPN_YEAST)
ATP synthase subunit g, mitochondrial
ATP20
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
GO - Molecular functioni
- proton transmembrane transporter activity Source: InterPro
GO - Biological processi
- ATP synthesis coupled proton transport Source: SGD
- cristae formation Source: SGD
- protein-containing complex assembly Source: SGD
Keywordsi
Biological process | ATP synthesis, Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-163210, Formation of ATP by chemiosmotic coupling R-SCE-8949613, Cristae formation |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit g, mitochondrialShort name: ATPase subunit g |
Gene namesi | Name:ATP20 Ordered Locus Names:YPR020W ORF Names:YP9531.14 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006224, ATP20 |
VEuPathDBi | FungiDB:YPR020W |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane By similarity
Mitochondrion
- mitochondrial inner membrane Source: ComplexPortal
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: SGD
- mitochondrion Source: SGD
Keywords - Cellular componenti
CF(0), Membrane, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 62 | S → A: No effect on ATP synthase dimerization. | 1 | |
Mutagenesisi | 62 | S → E: Inhibits ATP synthase dimerization. | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071696 | 1 – 115 | ATP synthase subunit g, mitochondrialAdd BLAST | 115 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Modified residuei | 62 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | Q12233 |
PaxDbi | Q12233 |
PRIDEi | Q12233 |
TopDownProteomicsi | Q12233 |
PTM databases
iPTMneti | Q12233 |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
Protein-protein interaction databases
BioGRIDi | 36197, 130 interactors |
ComplexPortali | CPX-3281, Mitochondrial proton-transporting ATP synthase complex |
DIPi | DIP-1207N |
IntActi | Q12233, 3 interactors |
MINTi | Q12233 |
STRINGi | 4932.YPR020W |
Miscellaneous databases
RNActi | Q12233, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4103, Eukaryota |
GeneTreei | ENSGT00390000009724 |
HOGENOMi | CLU_083674_1_0_1 |
InParanoidi | Q12233 |
OMAi | NIWTAKT |
Family and domain databases
InterProi | View protein in InterPro IPR006808, ATP_synth_F0_gsu_mt |
PANTHERi | PTHR12386, PTHR12386, 1 hit |
Pfami | View protein in Pfam PF04718, ATP-synt_G, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MLSRIQNYTS GLVSKANLLS SKALYYGKVG AEISKQIYLK EGLQPPTVAQ
60 70 80 90 100
FKSVYSNLYK QSLNFALKPT EVLSCLKNIQ KNELLKYGAY GIQLIGFYSV
110
GEIIGRRKLV GYKHH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71255 Genomic DNA Translation: CAA95016.1 Z49919 Genomic DNA Translation: CAA90165.1 AY692980 Genomic DNA Translation: AAT92999.1 BK006949 Genomic DNA Translation: DAA11446.1 |
PIRi | S57554 |
RefSeqi | NP_015345.1, NM_001184117.1 |
Genome annotation databases
EnsemblFungii | YPR020W_mRNA; YPR020W; YPR020W |
GeneIDi | 856131 |
KEGGi | sce:YPR020W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71255 Genomic DNA Translation: CAA95016.1 Z49919 Genomic DNA Translation: CAA90165.1 AY692980 Genomic DNA Translation: AAT92999.1 BK006949 Genomic DNA Translation: DAA11446.1 |
PIRi | S57554 |
RefSeqi | NP_015345.1, NM_001184117.1 |
3D structure databases
SMRi | Q12233 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36197, 130 interactors |
ComplexPortali | CPX-3281, Mitochondrial proton-transporting ATP synthase complex |
DIPi | DIP-1207N |
IntActi | Q12233, 3 interactors |
MINTi | Q12233 |
STRINGi | 4932.YPR020W |
PTM databases
iPTMneti | Q12233 |
Proteomic databases
MaxQBi | Q12233 |
PaxDbi | Q12233 |
PRIDEi | Q12233 |
TopDownProteomicsi | Q12233 |
Genome annotation databases
EnsemblFungii | YPR020W_mRNA; YPR020W; YPR020W |
GeneIDi | 856131 |
KEGGi | sce:YPR020W |
Organism-specific databases
SGDi | S000006224, ATP20 |
VEuPathDBi | FungiDB:YPR020W |
Phylogenomic databases
eggNOGi | KOG4103, Eukaryota |
GeneTreei | ENSGT00390000009724 |
HOGENOMi | CLU_083674_1_0_1 |
InParanoidi | Q12233 |
OMAi | NIWTAKT |
Enzyme and pathway databases
Reactomei | R-SCE-163210, Formation of ATP by chemiosmotic coupling R-SCE-8949613, Cristae formation |
Miscellaneous databases
PROi | PR:Q12233 |
RNActi | Q12233, protein |
Family and domain databases
InterProi | View protein in InterPro IPR006808, ATP_synth_F0_gsu_mt |
PANTHERi | PTHR12386, PTHR12386, 1 hit |
Pfami | View protein in Pfam PF04718, ATP-synt_G, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATPN_YEAST | |
Accessioni | Q12233Primary (citable) accession number: Q12233 Secondary accession number(s): D6W430 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families