UniProtKB - Q12184 (ADRX_YEAST)
Protein
Adrenodoxin homolog, mitochondrial
Gene
YAH1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins. May be part of a novel electron transport chain.1 Publication
Miscellaneous
Present with 14800 molecules/cell in log phase SD medium.1 Publication
Cofactori
[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 98 | Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 104 | Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 107 | Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 144 | Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: InterPro
- electron transfer activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Source: SGD
GO - Biological processi
- heme A biosynthetic process Source: SGD
- iron-sulfur cluster assembly Source: UniProtKB
- ubiquinone biosynthetic process Source: SGD
Keywordsi
Biological process | Electron transport, Transport |
Ligand | Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:G3O-34137-MONOMER |
Reactomei | R-SCE-1362409, Mitochondrial iron-sulfur cluster biogenesis R-SCE-2395516, Electron transport from NADPH to Ferredoxin |
Names & Taxonomyi
Protein namesi | Recommended name: Adrenodoxin homolog, mitochondrialAlternative name(s): Mitochondrial ferredoxin |
Gene namesi | Name:YAH1 Ordered Locus Names:YPL252C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YPL252C |
SGDi | S000006173, YAH1 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 2 Publications
Mitochondrion
- mitochondrial matrix Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | Mitochondrion | ||
ChainiPRO_0000000994 | ? – 172 | Adrenodoxin homolog, mitochondrial |
Proteomic databases
MaxQBi | Q12184 |
PaxDbi | Q12184 |
PRIDEi | Q12184 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35911, 7 interactors |
DIPi | DIP-5027N |
IntActi | Q12184, 2 interactors |
STRINGi | 4932.YPL252C |
Miscellaneous databases
RNActi | Q12184, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q12184 |
SMRi | Q12184 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 163 | 2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST | 103 |
Sequence similaritiesi
Belongs to the adrenodoxin/putidaredoxin family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3309, Eukaryota |
GeneTreei | ENSGT00940000161143 |
HOGENOMi | CLU_082632_0_2_1 |
InParanoidi | Q12184 |
OMAi | WQDPKSP |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
Gene3Di | 3.10.20.30, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR001055, Adrenodoxin IPR018298, Adrenodoxin_Fe-S_BS IPR012675, Beta-grasp_dom_sf |
Pfami | View protein in Pfam PF00111, Fer2, 1 hit |
PRINTSi | PR00355, ADRENODOXIN |
SUPFAMi | SSF54292, SSF54292, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS00814, ADX, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q12184-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKIVTRAGH TARISNIAAH LLRTSPSLLT RTTTTTRFLP FSTSSFLNHG
60 70 80 90 100
HLKKPKPGEE LKITFILKDG SQKTYEVCEG ETILDIAQGH NLDMEGACGG
110 120 130 140 150
SCACSTCHVI VDPDYYDALP EPEDDENDML DLAYGLTETS RLGCQIKMSK
160 170
DIDGIRVALP QMTRNVNNND FS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73608 Genomic DNA Translation: CAA97975.1 Z67751 Genomic DNA Translation: CAA91592.1 BK006949 Genomic DNA Translation: DAA11185.1 |
PIRi | S61012 |
RefSeqi | NP_015071.1, NM_001184066.1 |
Genome annotation databases
EnsemblFungii | YPL252C_mRNA; YPL252C; YPL252C |
GeneIDi | 855824 |
KEGGi | sce:YPL252C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73608 Genomic DNA Translation: CAA97975.1 Z67751 Genomic DNA Translation: CAA91592.1 BK006949 Genomic DNA Translation: DAA11185.1 |
PIRi | S61012 |
RefSeqi | NP_015071.1, NM_001184066.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MJD | NMR | - | A | 58-172 | [»] | |
2MJE | NMR | - | A | 58-172 | [»] | |
BMRBi | Q12184 | |||||
SMRi | Q12184 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35911, 7 interactors |
DIPi | DIP-5027N |
IntActi | Q12184, 2 interactors |
STRINGi | 4932.YPL252C |
Proteomic databases
MaxQBi | Q12184 |
PaxDbi | Q12184 |
PRIDEi | Q12184 |
Genome annotation databases
EnsemblFungii | YPL252C_mRNA; YPL252C; YPL252C |
GeneIDi | 855824 |
KEGGi | sce:YPL252C |
Organism-specific databases
EuPathDBi | FungiDB:YPL252C |
SGDi | S000006173, YAH1 |
Phylogenomic databases
eggNOGi | KOG3309, Eukaryota |
GeneTreei | ENSGT00940000161143 |
HOGENOMi | CLU_082632_0_2_1 |
InParanoidi | Q12184 |
OMAi | WQDPKSP |
Enzyme and pathway databases
BioCyci | MetaCyc:G3O-34137-MONOMER |
Reactomei | R-SCE-1362409, Mitochondrial iron-sulfur cluster biogenesis R-SCE-2395516, Electron transport from NADPH to Ferredoxin |
Miscellaneous databases
PROi | PR:Q12184 |
RNActi | Q12184, protein |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
Gene3Di | 3.10.20.30, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR001055, Adrenodoxin IPR018298, Adrenodoxin_Fe-S_BS IPR012675, Beta-grasp_dom_sf |
Pfami | View protein in Pfam PF00111, Fer2, 1 hit |
PRINTSi | PR00355, ADRENODOXIN |
SUPFAMi | SSF54292, SSF54292, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS00814, ADX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADRX_YEAST | |
Accessioni | Q12184Primary (citable) accession number: Q12184 Secondary accession number(s): D6W3B9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD