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Entry version 135 (26 Feb 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Endo-1,3(4)-beta-glucanase 2

Gene

ACF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 1420 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3. EC:3.2.1.6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32281-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH81 Glycoside Hydrolase Family 81

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endo-1,3(4)-beta-glucanase 2 (EC:3.2.1.6)
Short name:
Endo-1,3-beta-glucanase 2
Short name:
Endo-1,4-beta-glucanase 2
Alternative name(s):
Laminarinase-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACF2
Synonyms:ENG2, PCA1
Ordered Locus Names:YLR144C
ORF Names:L3180
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YLR144C

Saccharomyces Genome Database

More...
SGDi
S000004134 ACF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002158191 – 779Endo-1,3(4)-beta-glucanase 2Add BLAST779

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12168

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12168

PRoteomics IDEntifications database

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PRIDEi
Q12168

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12168

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31413, 71 interactors

Database of interacting proteins

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DIPi
DIP-2889N

Protein interaction database and analysis system

More...
IntActi
Q12168, 19 interactors

Molecular INTeraction database

More...
MINTi
Q12168

STRING: functional protein association networks

More...
STRINGi
4932.YLR144C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12168 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 81 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005482_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q12168

KEGG Orthology (KO)

More...
KOi
K01180

Identification of Orthologs from Complete Genome Data

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OMAi
FAHGIFA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005200 Endo-beta-glucanase
IPR040720 GH81_C
IPR040451 GH81_N

The PANTHER Classification System

More...
PANTHERi
PTHR31983 PTHR31983, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17652 Glyco_hydro81C, 1 hit
PF03639 Glyco_hydro_81, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12168-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCYSRQAIPP PVPNRPGGTT NRGPPPLPPR ANVQPPVCSS ENSSKPRENR
60 70 80 90 100
VAGESLRTPS SSNPLADSQV NSDNIFQSPV LSNLKAPPSV FNKVQHPVPK
110 120 130 140 150
PNIDDQSVDP LETNKFYTNM LLDDNTQPIW THPYSIWFSR DPELFGLAAN
160 170 180 190 200
HTLASQRVFD TTTNPPRFYF NPTNIKSFVF KAREFVSSND IKLEFRDMKH
210 220 230 240 250
MSMCLLMSLS SSQFIEFPLV QGMGFVTAIY HDLGFELRSA VGFRSLERIS
260 270 280 290 300
VNERYGKYNI QLENNRNWIL YLTSPDYSFP QDFQISLLDS NTIISSHKIN
310 320 330 340 350
GLICQLSADS VPSIDMAAGC YPVYCDLSGQ TVDEHFTNYR FNYTVAGYSQ
360 370 380 390 400
SGTTLMYALP HHKAAFTPEM QEREIASSLD STVKGLMTGY LTNSFDMQVQ
410 420 430 440 450
VPQELGFEPV ALSLNKKADY SQEKLSKIRE AAVQEVQLSD PQQESNIDSM
460 470 480 490 500
YFSGKILAKY AWILYVTHYI LHDENLTKEL LSKLTIAMER FISNQQVLPL
510 520 530 540 550
NYDVSWKGII SSGSSSQDFG NSYYNDHHFH YSYHVITAAI ISLVDSDLSG
560 570 580 590 600
VTNNSWLENN RDWVECLIRD YSGVDNDDPY FPQFRSFDWF NGHSWAKGLF
610 620 630 640 650
PSGDGKDEES TSEDVNSCYA IKLWGLVTGN SKLTDIANLQ LGIMRNVFQS
660 670 680 690 700
YFLYESNNTV QPKEFIGNKV SGILFENKID HATYFGMEPQ YIHMIHAIPI
710 720 730 740 750
TSASSWVRTP NFVKEEWEEK MQPIIDQVND GWKGIIMLNM ALLDPKFSYD
760 770
FFSQPDFNRN FLDNGQSLTW SLAYSGAFS
Length:779
Mass (Da):88,403
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BCC24DF96414FA7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U53879 Genomic DNA Translation: AAB82378.1
Z73316 Genomic DNA Translation: CAA97716.1
X91258 Genomic DNA Translation: CAA62664.1
BK006945 Genomic DNA Translation: DAA09454.1

Protein sequence database of the Protein Information Resource

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PIRi
S64993

NCBI Reference Sequences

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RefSeqi
NP_013245.1, NM_001182031.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR144C_mRNA; YLR144C; YLR144C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR144C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53879 Genomic DNA Translation: AAB82378.1
Z73316 Genomic DNA Translation: CAA97716.1
X91258 Genomic DNA Translation: CAA62664.1
BK006945 Genomic DNA Translation: DAA09454.1
PIRiS64993
RefSeqiNP_013245.1, NM_001182031.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi31413, 71 interactors
DIPiDIP-2889N
IntActiQ12168, 19 interactors
MINTiQ12168
STRINGi4932.YLR144C

Protein family/group databases

CAZyiGH81 Glycoside Hydrolase Family 81

PTM databases

iPTMnetiQ12168

Proteomic databases

MaxQBiQ12168
PaxDbiQ12168
PRIDEiQ12168

Genome annotation databases

EnsemblFungiiYLR144C_mRNA; YLR144C; YLR144C
GeneIDi850836
KEGGisce:YLR144C

Organism-specific databases

EuPathDBiFungiDB:YLR144C
SGDiS000004134 ACF2

Phylogenomic databases

HOGENOMiCLU_005482_2_1_1
InParanoidiQ12168
KOiK01180
OMAiFAHGIFA

Enzyme and pathway databases

BioCyciYEAST:G3O-32281-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12168
RNActiQ12168 protein

Family and domain databases

InterProiView protein in InterPro
IPR005200 Endo-beta-glucanase
IPR040720 GH81_C
IPR040451 GH81_N
PANTHERiPTHR31983 PTHR31983, 1 hit
PfamiView protein in Pfam
PF17652 Glyco_hydro81C, 1 hit
PF03639 Glyco_hydro_81, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENG2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12168
Secondary accession number(s): D6VYD8, Q07268
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1996
Last modified: February 26, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  4. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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