The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q12125 (GET4_YEAST)
Protein
Golgi to ER traffic protein 4
Gene
GET4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
1 PublicationMiscellaneous
Present with 5350 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- posttranslational protein targeting to endoplasmic reticulum membrane Source: SGD
- protein insertion into ER membrane Source: SGD
- vesicle-mediated transport Source: UniProtKB-KW
Keywordsi
Biological process | ER-Golgi transport, Transport |
Protein family/group databases
TCDBi | 3.A.21.1.1, the c-terminal tail-anchored membrane protein biogenesis/ insertion complex (tamp-b) family |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi to ER traffic protein 4Alternative name(s): Guided entry of tail-anchored proteins 4 |
Gene namesi | Name:GET4 Ordered Locus Names:YOR164C ORF Names:O3580 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005690, GET4 |
VEuPathDBi | FungiDB:YOR164C |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: GO_Central
- TRC complex Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000228107 | 1 – 312 | Golgi to ER traffic protein 4Add BLAST | 312 |
Proteomic databases
MaxQBi | Q12125 |
PaxDbi | Q12125 |
PRIDEi | Q12125 |
PTM databases
iPTMneti | Q12125 |
Interactioni
Subunit structurei
Interacts with MDY2/GET5.
1 PublicationBinary interactionsi
Q12125
With | #Exp. | IntAct |
---|---|---|
GET3 [Q12154] | 11 | EBI-36940,EBI-2989 |
MDY2 [Q12285] | 17 | EBI-36940,EBI-34904 |
SEC22 [P22214] | 2 | EBI-36940,EBI-16577 |
SGT2 [Q12118] | 5 | EBI-36940,EBI-31784 |
Protein-protein interaction databases
BioGRIDi | 34560, 267 interactors |
ComplexPortali | CPX-1861, GET4-GET5 transmembrane domain recognition complex |
DIPi | DIP-2005N |
IntActi | Q12125, 13 interactors |
MINTi | Q12125 |
STRINGi | 4932.YOR164C |
Miscellaneous databases
RNActi | Q12125, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q12125 |
SMRi | Q12125 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q12125 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GET4 family.Curated
Phylogenomic databases
eggNOGi | KOG3024, Eukaryota |
GeneTreei | ENSGT00390000015750 |
HOGENOMi | CLU_046061_0_2_1 |
InParanoidi | Q12125 |
OMAi | QIGEMYF |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR007317, GET4 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12875, PTHR12875, 1 hit |
Pfami | View protein in Pfam PF04190, GET4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q12125-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVPAESNAVQ AKLAKTLQRF ENKIKAGDYY EAHQTLRTIA NRYVRSKSYE
60 70 80 90 100
HAIELISQGA LSFLKAKQGG SGTDLIFYLL EVYDLAEVKV DDISVARLVR
110 120 130 140 150
LIAELDPSEP NLKDVITGMN NWSIKFSEYK FGDPYLHNTI GSKLLEGDFV
160 170 180 190 200
YEAERYFMLG THDSMIKYVD LLWDWLCQVD DIEDSTVAEF FSRLVFNYLF
210 220 230 240 250
ISNISFAHES KDIFLERFIE KFHPKYEKID KNGYEIVFFE DYSDLNFLQL
260 270 280 290 300
LLITCQTKDK SYFLNLKNHY LDFSQAYKSE LEFLGQEYFN IVAPKQTNFL
310
QDMMSGFLGG SK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U55021 Genomic DNA Translation: AAB47411.1 Z75072 Genomic DNA Translation: CAA99370.1 AY558036 Genomic DNA Translation: AAS56362.1 BK006948 Genomic DNA Translation: DAA10938.1 |
PIRi | S67052 |
RefSeqi | NP_014807.3, NM_001183583.3 |
Genome annotation databases
EnsemblFungii | YOR164C_mRNA; YOR164C; YOR164C |
GeneIDi | 854335 |
KEGGi | sce:YOR164C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U55021 Genomic DNA Translation: AAB47411.1 Z75072 Genomic DNA Translation: CAA99370.1 AY558036 Genomic DNA Translation: AAS56362.1 BK006948 Genomic DNA Translation: DAA10938.1 |
PIRi | S67052 |
RefSeqi | NP_014807.3, NM_001183583.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WPV | X-ray | 1.99 | A/C/E/G | 1-312 | [»] | |
3LKU | X-ray | 2.80 | A/C/E | 11-300 | [»] | |
4PWX | X-ray | 5.40 | C/E | 11-290 | [»] | |
5BW8 | X-ray | 2.80 | C | 1-290 | [»] | |
5BWK | X-ray | 6.00 | E/G/I/K/Q/S/U/W | 11-311 | [»] | |
AlphaFoldDBi | Q12125 | |||||
SMRi | Q12125 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34560, 267 interactors |
ComplexPortali | CPX-1861, GET4-GET5 transmembrane domain recognition complex |
DIPi | DIP-2005N |
IntActi | Q12125, 13 interactors |
MINTi | Q12125 |
STRINGi | 4932.YOR164C |
Protein family/group databases
TCDBi | 3.A.21.1.1, the c-terminal tail-anchored membrane protein biogenesis/ insertion complex (tamp-b) family |
PTM databases
iPTMneti | Q12125 |
Proteomic databases
MaxQBi | Q12125 |
PaxDbi | Q12125 |
PRIDEi | Q12125 |
Genome annotation databases
EnsemblFungii | YOR164C_mRNA; YOR164C; YOR164C |
GeneIDi | 854335 |
KEGGi | sce:YOR164C |
Organism-specific databases
SGDi | S000005690, GET4 |
VEuPathDBi | FungiDB:YOR164C |
Phylogenomic databases
eggNOGi | KOG3024, Eukaryota |
GeneTreei | ENSGT00390000015750 |
HOGENOMi | CLU_046061_0_2_1 |
InParanoidi | Q12125 |
OMAi | QIGEMYF |
Miscellaneous databases
EvolutionaryTracei | Q12125 |
PROi | PR:Q12125 |
RNActi | Q12125, protein |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR007317, GET4 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12875, PTHR12875, 1 hit |
Pfami | View protein in Pfam PF04190, GET4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GET4_YEAST | |
Accessioni | Q12125Primary (citable) accession number: Q12125 Secondary accession number(s): D6W2M2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families