UniProtKB - Q12119 (FCY22_YEAST)
Protein
Purine-cytosine permease FCY22
Gene
FCY22
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Probable purine-cytosine permease.By similarity
GO - Molecular functioni
- nucleobase transmembrane transporter activity Source: SGD
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cytosine transport Source: SGD
- purine-containing compound transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Purine-cytosine permease FCY22Short name: PCP FCY22 Alternative name(s): Cytosine/purine transport protein FCY22 Fluorocytosine resistance protein 22 |
Gene namesi | Name:FCY22 Synonyms:FCYX Ordered Locus Names:YER060W-A |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YER060W-A |
SGDi | S000002958, FCY22 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: SGD
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 217 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 220 – 240 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 263 – 283 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 298 – 318 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 372 – 392 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 396 – 416 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 418 – 438 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 463 – 483 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197922 | 1 – 530 | Purine-cytosine permease FCY22Add BLAST | 530 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 46 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q12119 |
PRIDEi | Q12119 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36802, 104 interactors |
DIPi | DIP-8900N |
STRINGi | 4932.YER060W-A |
Miscellaneous databases
RNActi | Q12119, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the purine-cytosine permease (2.A.39) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQ8Y, Eukaryota |
GeneTreei | ENSGT00940000176331 |
HOGENOMi | CLU_026016_2_2_1 |
InParanoidi | Q12119 |
OMAi | ISCIGWN |
Family and domain databases
Gene3Di | 1.10.4160.10, 1 hit |
InterProi | View protein in InterPro IPR012681, NCS1 IPR001248, Pur-cyt_permease IPR026030, Pur-cyt_permease_Fcy2/21/22 IPR038271, Pur-cyt_permease_sf |
PANTHERi | PTHR31806, PTHR31806, 1 hit |
Pfami | View protein in Pfam PF02133, Transp_cyt_pur, 1 hit |
PIRSFi | PIRSF002744, Pur-cyt_permease, 1 hit |
TIGRFAMsi | TIGR00800, ncs1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q12119-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEKLAMSMV DIKDAGSELR DLESGALDTK SSAADVYYEG VELHRTNEFI
60 70 80 90 100
DNKPSFFNRI AAALNAETKG IEPVTEDEKN DDSILNAATI WFSANMVIVA
110 120 130 140 150
YSVGALGPLV FGLNFGQSVL VIIFFNILGL IPVALFSLFG VELGLRQMIL
160 170 180 190 200
SRYLAGNITA RFFSLVNVIA CVGWCVLNIS VSAQLLNMVN EGSGHNCPIW
210 220 230 240 250
AGCLIIAGGT VLVTFFGYSV VHAYEKWSWV PNFAAFLVII AQLSRSGKFK
260 270 280 290 300
GGEWVGGATT AGGVLSFGSS VFGSAAGWAT YAADYTVYMP KTTSKYKIFF
310 320 330 340 350
SVVAGLAFPL FFTMILGAAC GMAALNDPTW KSYYDKNAMG GVIYAILVPN
360 370 380 390 400
SLNGFGQFCC VLLALSTVAN NVPGMYTVAL SAQALWAPLA KIPRVVWTMA
410 420 430 440 450
GNAATLGISI PATYYFDGFM ENFMDSIGYY LAIYIAIACS EHFIYRRSFS
460 470 480 490 500
AYNIDDWDNW EHLPIGIAGT AALIAGAFGV ALGMCQTYWV GEISRLIGEY
510 520 530
GGDIGFELGG SWAFIIYNIV RPLELKYFGR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97346 Genomic DNA Translation: CAA66033.1 U18813 Genomic DNA Translation: AAB64610.1 BK006939 Genomic DNA Translation: DAA07719.1 |
RefSeqi | NP_010982.1, NM_001180858.1 |
Genome annotation databases
EnsemblFungii | YER060W-A_mRNA; YER060W-A; YER060W-A |
GeneIDi | 856789 |
KEGGi | sce:YER060W-A |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97346 Genomic DNA Translation: CAA66033.1 U18813 Genomic DNA Translation: AAB64610.1 BK006939 Genomic DNA Translation: DAA07719.1 |
RefSeqi | NP_010982.1, NM_001180858.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36802, 104 interactors |
DIPi | DIP-8900N |
STRINGi | 4932.YER060W-A |
Proteomic databases
PaxDbi | Q12119 |
PRIDEi | Q12119 |
Genome annotation databases
EnsemblFungii | YER060W-A_mRNA; YER060W-A; YER060W-A |
GeneIDi | 856789 |
KEGGi | sce:YER060W-A |
Organism-specific databases
EuPathDBi | FungiDB:YER060W-A |
SGDi | S000002958, FCY22 |
Phylogenomic databases
eggNOGi | ENOG502QQ8Y, Eukaryota |
GeneTreei | ENSGT00940000176331 |
HOGENOMi | CLU_026016_2_2_1 |
InParanoidi | Q12119 |
OMAi | ISCIGWN |
Miscellaneous databases
PROi | PR:Q12119 |
RNActi | Q12119, protein |
Family and domain databases
Gene3Di | 1.10.4160.10, 1 hit |
InterProi | View protein in InterPro IPR012681, NCS1 IPR001248, Pur-cyt_permease IPR026030, Pur-cyt_permease_Fcy2/21/22 IPR038271, Pur-cyt_permease_sf |
PANTHERi | PTHR31806, PTHR31806, 1 hit |
Pfami | View protein in Pfam PF02133, Transp_cyt_pur, 1 hit |
PIRSFi | PIRSF002744, Pur-cyt_permease, 1 hit |
TIGRFAMsi | TIGR00800, ncs1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FCY22_YEAST | |
Accessioni | Q12119Primary (citable) accession number: Q12119 Secondary accession number(s): D3DLW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD