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UniProtKB - Q12051 (GGPPS_YEAST)

Entry version 159 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Geranylgeranyl pyrophosphate synthase

Gene

BTS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.2 Publications

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Binds 2 Mg2+ ions per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.2 µM for farnesyl diphosphate
  2. KM=0.8 µM for isopentenyl diphosphate

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: farnesyl diphosphate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
    Proteins known to be involved in this subpathway in this organism are:
    1. Geranylgeranyl pyrophosphate synthase (BTS1), Farnesyl pyrophosphate synthase (ERG20)
    This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

    Pathwayi: geranyl diphosphate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
    Proteins known to be involved in this subpathway in this organism are:
    1. Geranylgeranyl pyrophosphate synthase (BTS1), Farnesyl pyrophosphate synthase (ERG20)
    This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

    Pathwayi: geranylgeranyl diphosphate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate.
    Proteins known to be involved in this subpathway in this organism are:
    1. Geranylgeranyl pyrophosphate synthase (BTS1)
    This subpathway is part of the pathway geranylgeranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate, the pathway geranylgeranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36Isopentenyl diphosphate1 Publication1
    Binding sitei39Isopentenyl diphosphate1 Publication1
    Binding sitei68Isopentenyl diphosphate1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi75Magnesium 12 Publications1
    Metal bindingi75Magnesium 22 Publications1
    Metal bindingi79Magnesium 12 Publications1
    Metal bindingi79Magnesium 22 Publications1
    Binding sitei84Dimethylallyl diphosphate1 Publication1
    Binding sitei85Isopentenyl diphosphate1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei107Important for determining product chain length1
    Binding sitei169Dimethylallyl diphosphate1 Publication1
    Binding sitei170Dimethylallyl diphosphate1 Publication1
    Binding sitei206Dimethylallyl diphosphate1 Publication1
    Binding sitei213Dimethylallyl diphosphate1 Publication1
    Binding sitei223Dimethylallyl diphosphate1 Publication1
    Binding sitei233Dimethylallyl diphosphate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processCarotenoid biosynthesis, Isoprene biosynthesis, Protein transport, Transport
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:YPL069C-MONOMER
    YEAST:YPL069C-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.5.1.29, 984

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-SCE-191273, Cholesterol biosynthesis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q12051

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00259;UER00368
    UPA00260;UER00369
    UPA00389;UER00564

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Geranylgeranyl pyrophosphate synthase (EC:2.5.1.-)
    Short name:
    GGPP synthase
    Short name:
    GGPPSase
    Alternative name(s):
    (2E,6E)-farnesyl diphosphate synthase
    BET2 suppressor protein 1
    Dimethylallyltranstransferase (EC:2.5.1.1)
    Farnesyl diphosphate synthase
    Farnesyltranstransferase (EC:2.5.1.29)
    Geranylgeranyl diphosphate synthase
    Geranyltranstransferase (EC:2.5.1.10)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:BTS1
    Ordered Locus Names:YPL069C
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		FungiDB:YPL069C

    Saccharomyces Genome Database

    More...    SGDi    		S000005990, BTS1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7E → G: No effect. Monomer; when associated with G-8. 1 Publication1
    Mutagenesisi8L → G: Monomer and homodimer. Monomer; when associated with G-7. 1 Publication1
    Mutagenesisi9I → G: Mostly monomer. Exclusively monomer; when associated with G-8. Reduces enzyme activity 1000-fold. 1 Publication1
    Mutagenesisi107Y → A: Reduced affinity for isopentenyl diphosphate (IPP). 1
    Mutagenesisi108F → A: Reduced affinity for isopentenyl diphosphate (IPP). 1
    Mutagenesisi139H → A: Reduced affinity for isopentenyl diphosphate (IPP). 1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL1075251

    DrugCentral

    More...    DrugCentrali    		Q12051

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002281391 – 335Geranylgeranyl pyrophosphate synthaseAdd BLAST335

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q12051

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q12051

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q12051

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		36110, 1025 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-8889N

    Protein interaction database and analysis system

    More...    IntActi    		Q12051, 5 interactors

    STRING: functional protein association networks

    More...    STRINGi    		4932.YPL069C

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q12051

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q12051, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1335
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q12051

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q12051

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0777, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000153498

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_014015_6_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q12051

    KEGG Orthology (KO)

    More...    KOi    		K00804

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		HTKSFDY

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.600.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR008949, Isoprenoid_synthase_dom_sf
    IPR000092, Polyprenyl_synt
    IPR033749, Polyprenyl_synt_CS

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00348, polyprenyl_synt, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48576, SSF48576, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00723, POLYPRENYL_SYNTHASE_1, 1 hit
    PS00444, POLYPRENYL_SYNTHASE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q12051-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEAKIDELIN NDPVWSSQNE SLISKPYNHI LLKPGKNFRL NLIVQINRVM 
            60         70         80         90        100
    NLPKDQLAIV SQIVELLHNS SLLIDDIEDN APLRRGQTTS HLIFGVPSTI 
           110        120        130        140        150
    NTANYMYFRA MQLVSQLTTK EPLYHNLITI FNEELINLHR GQGLDIYWRD 
           160        170        180        190        200
    FLPEIIPTQE MYLNMVMNKT GGLFRLTLRL MEALSPSSHH GHSLVPFINL 
           210        220        230        240        250
    LGIIYQIRDD YLNLKDFQMS SEKGFAEDIT EGKLSFPIVH ALNFTKTKGQ 
           260        270        280        290        300
    TEQHNEILRI LLLRTSDKDI KLKLIQILEF DTNSLAYTKN FINQLVNMIK 
           310        320        330 
    NDNENKYLPD LASHSDTATN LHDELLYIID HLSEL
    Length:335
    Mass (Da):38,651
    Last modified:November 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C7D6527FF29F157
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U39205 Genomic DNA Translation: AAB68296.1
    U31632 Genomic DNA Translation: AAA83262.1
    AY692852 Genomic DNA Translation: AAT92871.1
    BK006949 Genomic DNA Translation: DAA11362.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		S60921

    NCBI Reference Sequences

    More...    RefSeqi    		NP_015256.1, NM_001183883.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...    EnsemblFungii    		YPL069C_mRNA; YPL069C; YPL069C

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		856036

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		sce:YPL069C

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U39205 Genomic DNA Translation: AAB68296.1
    U31632 Genomic DNA Translation: AAA83262.1
    AY692852 Genomic DNA Translation: AAT92871.1
    BK006949 Genomic DNA Translation: DAA11362.1
    PIRiS60921
    RefSeqiNP_015256.1, NM_001183883.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2DH4X-ray1.98A/B1-335[»]
    2E8TX-ray2.13A/B1-335[»]
    2E8UX-ray2.08A/B1-335[»]
    2E8VX-ray1.80A/B1-335[»]
    2E8WX-ray2.35A/B1-335[»]
    2E8XX-ray2.04A/B1-335[»]
    2E90X-ray2.55A/B1-335[»]
    2E91X-ray2.14A/B1-335[»]
    2E92X-ray2.31A/B1-335[»]
    2E93X-ray2.12A/B1-335[»]
    2E94X-ray2.18A/B1-335[»]
    2E95X-ray2.20A/B1-335[»]
    2Z4VX-ray1.86A/B1-335[»]
    2Z4WX-ray2.45A/B1-335[»]
    2Z4XX-ray1.90A/B1-335[»]
    2Z4YX-ray2.10A/B1-335[»]
    2Z4ZX-ray2.09A/B1-335[»]
    2Z50X-ray2.01A/B1-335[»]
    2Z52X-ray2.13A/B1-335[»]
    2Z78X-ray2.10A/B1-335[»]
    2Z7HX-ray2.08A/B1-335[»]
    2Z7IX-ray2.10A/B1-335[»]
    2ZEUX-ray2.00A/B1-335[»]
    2ZEVX-ray2.23A/B1-335[»]
    SMRiQ12051
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi36110, 1025 interactors
    DIPiDIP-8889N
    IntActiQ12051, 5 interactors
    STRINGi4932.YPL069C

    Chemistry databases

    BindingDBiQ12051
    ChEMBLiCHEMBL1075251
    DrugCentraliQ12051

    Proteomic databases

    MaxQBiQ12051
    PaxDbiQ12051
    PRIDEiQ12051

    Genome annotation databases

    EnsemblFungiiYPL069C_mRNA; YPL069C; YPL069C
    GeneIDi856036
    KEGGisce:YPL069C

    Organism-specific databases

    EuPathDBiFungiDB:YPL069C
    SGDiS000005990, BTS1

    Phylogenomic databases

    eggNOGiKOG0777, Eukaryota
    GeneTreeiENSGT00940000153498
    HOGENOMiCLU_014015_6_0_1
    InParanoidiQ12051
    KOiK00804
    OMAiHTKSFDY

    Enzyme and pathway databases

    UniPathwayiUPA00259;UER00368
    UPA00260;UER00369
    UPA00389;UER00564
    BioCyciMetaCyc:YPL069C-MONOMER
    YEAST:YPL069C-MONOMER
    BRENDAi2.5.1.29, 984
    ReactomeiR-SCE-191273, Cholesterol biosynthesis
    SABIO-RKiQ12051

    Miscellaneous databases

    EvolutionaryTraceiQ12051

    Protein Ontology

    More...    PROi    		PR:Q12051
    RNActiQ12051, protein

    Family and domain databases

    Gene3Di1.10.600.10, 1 hit
    InterProiView protein in InterPro
    IPR008949, Isoprenoid_synthase_dom_sf
    IPR000092, Polyprenyl_synt
    IPR033749, Polyprenyl_synt_CS
    PfamiView protein in Pfam
    PF00348, polyprenyl_synt, 1 hit
    SUPFAMiSSF48576, SSF48576, 1 hit
    PROSITEiView protein in PROSITE
    PS00723, POLYPRENYL_SYNTHASE_1, 1 hit
    PS00444, POLYPRENYL_SYNTHASE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGPPS_YEAST
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12051
    Secondary accession number(s): D6W3U6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: November 1, 1996
    Last modified: August 12, 2020
    This is version 159 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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