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Entry version 175 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Lethal(2) giant larvae protein homolog SRO7

Gene

SRO7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Coordinates the spatial and temporal nature of both Rab-dependent tethering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane. Required for targeting of the sodium pumping ATPase ENA1 to the Cell Surface, thus being involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lethal(2) giant larvae protein homolog SRO7
Alternative name(s):
Polarity protein SRO7
Sodium protection protein 1
Suppressor of RHO3 protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRO7
Synonyms:SNI1, SOP1
Ordered Locus Names:YPR032W
ORF Names:YP9367.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000006236, SRO7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPR032W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720081 – 1033Lethal(2) giant larvae protein homolog SRO7Add BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei591PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12038

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12038

PRoteomics IDEntifications database

More...
PRIDEi
Q12038

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12038

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYO2 and SEC9.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36210, 651 interactors

Database of interacting proteins

More...
DIPi
DIP-2581N

Protein interaction database and analysis system

More...
IntActi
Q12038, 8 interactors

Molecular INTeraction database

More...
MINTi
Q12038

STRING: functional protein association networks

More...
STRINGi
4932.YPR032W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12038, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11033
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12038

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q12038

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati81 – 114WD 11 PublicationAdd BLAST34
Repeati121 – 156WD 21 PublicationAdd BLAST36
Repeati161 – 197WD 31 PublicationAdd BLAST37
Repeati216 – 249WD 41 PublicationAdd BLAST34
Repeati274 – 309WD 51 PublicationAdd BLAST36
Repeati333 – 397WD 61 PublicationAdd BLAST65
Repeati405 – 440WD 71 PublicationAdd BLAST36
Repeati464 – 538WD 81 PublicationAdd BLAST75
Repeati552 – 631WD 91 PublicationAdd BLAST80
Repeati638 – 673WD 101 PublicationAdd BLAST36
Repeati685 – 736WD 111 PublicationAdd BLAST52
Repeati745 – 799WD 121 PublicationAdd BLAST55
Repeati804 – 851WD 131 PublicationAdd BLAST48
Repeati865 – 888WD 141 PublicationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 52Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1983, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182906

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006030_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12038

Identification of Orthologs from Complete Genome Data

More...
OMAi
YVFGQRR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013905, Lgl_C_dom
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08596, Lgl_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGSKRLKNV KEAFKSLKGQ NSETPIENSK ASFKSKNSKT STISKDAKSS
60 70 80 90 100
SSLKIPISSN NKNKIFSLAE TNKYGMSSKP IAAAFDFTQN LLAIATVTGE
110 120 130 140 150
VHIYGQQQVE VVIKLEDRSA IKEMRFVKGI YLVVINAKDT VYVLSLYSQK
160 170 180 190 200
VLTTVFVPGK ITSIDTDASL DWMLIGLQNG SMIVYDIDRD QLSSFKLDNL
210 220 230 240 250
QKSSFFPAAR LSPIVSIQWN PRDIGTVLIS YEYVTLTYSL VENEIKQSFI
260 270 280 290 300
YELPPFAPGG DFSEKTNEKR TPKVIQSLYH PNSLHIITIH EDNSLVFWDA
310 320 330 340 350
NSGHMIMART VFETEINVPQ PDYIRDSSTN AAKISKVYWM CENNPEYTSL
360 370 380 390 400
LISHKSISRG DNQSLTMIDL GYTPRYSITS YEGMKNYYAN PKQMKIFPLP
410 420 430 440 450
TNVPIVNILP IPRQSPYFAG CHNPGLILLI LGNGEIETML YPSGIFTDKA
460 470 480 490 500
SLFPQNLSWL RPLATTSMAA SVPNKLWLGA LSAAQNKDYL LKGGVRTKRQ
510 520 530 540 550
KLPAEYGTAF ITGHSNGSVR IYDASHGDIQ DNASFEVNLS RTLNKAKELA
560 570 580 590 600
VDKISFAAET LELAVSIETG DVVLFKYEVN QFYSVENRPE SGDLEMNFRR
610 620 630 640 650
FSLNNTNGVL VDVRDRAPTG VRQGFMPSTA VHANKGKTSA INNSNIGFVG
660 670 680 690 700
IAYAAGSLML IDRRGPAIIY MENIREISGA QSACVTCIEF VIMEYGDDGY
710 720 730 740 750
SSILMVCGTD MGEVITYKIL PASGGKFDVQ LMDITNVTSK GPIHKIDAFS
760 770 780 790 800
KETKSSCLAT IPKMQNLSKG LCIPGIVLIT GFDDIRLITL GKSKSTHKGF
810 820 830 840 850
KYPLAATGLS YISTVEKNND RKNLTVIITL EINGHLRVFT IPDFKEQMSE
860 870 880 890 900
HIPFPIAAKY ITESSVLRNG DIAIRVSEFQ ASLFSTVKEQ DTLAPVSDTL
910 920 930 940 950
YINGIRIPYR PQVNSLQWAR GTVYCTPAQL NELLGGVNRP ASKYKESIIA
960 970 980 990 1000
EGSFSERSSD DNNANHPEHQ YTKPTRKGRN SSYGVLRNVS RAVETRWDAV
1010 1020 1030
EDRFNDYATA MGETMNEAVE QTGKDVMKGA LGF
Length:1,033
Mass (Da):114,513
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFB0901883009815
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95028.1
Z49274 Genomic DNA Translation: CAA89286.1
BK006949 Genomic DNA Translation: DAA11458.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54506

NCBI Reference Sequences

More...
RefSeqi
NP_015357.1, NM_001184129.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR032W_mRNA; YPR032W; YPR032W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR032W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95028.1
Z49274 Genomic DNA Translation: CAA89286.1
BK006949 Genomic DNA Translation: DAA11458.1
PIRiS54506
RefSeqiNP_015357.1, NM_001184129.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OAJX-ray2.40A61-962[»]
SMRiQ12038
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36210, 651 interactors
DIPiDIP-2581N
IntActiQ12038, 8 interactors
MINTiQ12038
STRINGi4932.YPR032W

PTM databases

iPTMnetiQ12038

Proteomic databases

MaxQBiQ12038
PaxDbiQ12038
PRIDEiQ12038

Genome annotation databases

EnsemblFungiiYPR032W_mRNA; YPR032W; YPR032W
GeneIDi856144
KEGGisce:YPR032W

Organism-specific databases

SGDiS000006236, SRO7
VEuPathDBiFungiDB:YPR032W

Phylogenomic databases

eggNOGiKOG1983, Eukaryota
GeneTreeiENSGT00950000182906
HOGENOMiCLU_006030_0_0_1
InParanoidiQ12038
OMAiYVFGQRR

Miscellaneous databases

EvolutionaryTraceiQ12038

Protein Ontology

More...
PROi
PR:Q12038
RNActiQ12038, protein

Family and domain databases

InterProiView protein in InterPro
IPR013905, Lgl_C_dom
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08596, Lgl_C, 1 hit
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRO7_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12038
Secondary accession number(s): D6W442
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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