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Entry version 156 (05 Jun 2019)
Sequence version 1 (01 Nov 1996)
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Protein

AP-1 complex subunit gamma-1

Gene

APL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin.1 Publication

Miscellaneous

Present with 4850 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • clathrin binding Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-34188-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-432720 Lysosome Vesicle Biogenesis
R-SCE-432722 Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-1 complex subunit gamma-1
Alternative name(s):
Clathrin assembly protein complex 1 gamma large chain
Clathrin assembly protein large gamma chain
Gamma-adaptin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APL4
Ordered Locus Names:YPR029C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YPR029C

Saccharomyces Genome Database

More...
SGDi
S000006233 APL4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937641 – 832AP-1 complex subunit gamma-1Add BLAST832

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12028

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12028

PRoteomics IDEntifications database

More...
PRIDEi
Q12028

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12028

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
36207, 180 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-532 Adapter complex AP-1
CPX-533 Adapter complex AP-1R

Database of interacting proteins

More...
DIPi
DIP-3913N

Protein interaction database and analysis system

More...
IntActi
Q12028, 30 interactors

Molecular INTeraction database

More...
MINTi
Q12028

STRING: functional protein association networks

More...
STRINGi
4932.YPR029C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12028

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini733 – 832GAEAdd BLAST100

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182838

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000210271

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12028

KEGG Orthology (KO)

More...
KOi
K12391

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRHRNII

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037094 AP1_complex_gamma, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00809 Alpha_adaptinC2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12028-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSLRSFIK DVRGAKTLAD ERAIITKQSA KIRTKLRDDH LPHEKRRVNI
60 70 80 90 100
QKLLYLYILG EKTHFGQVES INLIASDDFV DKRLGYLAAT LLLDESEDLL
110 120 130 140 150
TLLTNMLNND LHHPNKYAVS LALTSLGFLS SPELARDLYP DVENIIKNSR
160 170 180 190 200
DPFLLKKALQ CAAKLIFKDV SLLEIFNIED ITKILSSHSI CTHGVLLGVT
210 220 230 240 250
KIIQSILLIG LNRKKDEDED EDGIDYSNDI LSPLSLLLRD FFIRLENMNS
260 270 280 290 300
KNIEPGYDVQ GICDPFLQCE IIYTLKLYFQ VGELLNSNNV LDYKDNFCDL
310 320 330 340 350
LTRIATNTDS TKNSGQAILY ETVKTIFSLD LNQPLRVLGI NILAKFLAGK
360 370 380 390 400
DNNTKYVSLN TLLKVVPQEP TAVQRHRKFI SHCLQDTDVS IRMRALELSF
410 420 430 440 450
AILDDSNLVE LVNELMKFLA KQDEDSKDLI IYTIDHLIDT FDTRVVKDES
460 470 480 490 500
WKLDVFFNIL KLVGSFINYE KINDILIIIN NTSQLSDKSE FLRKMLTISL
510 520 530 540 550
NGTSAEISEE NIGWQLVLIW CIGEYGDLVL NEGNKNGADI INESSITDYL
560 570 580 590 600
LTLQELYTAT NLKIINYILT AALKLSVRFH DAKNIEKLRQ LILSYTDSTD
610 620 630 640 650
LSLQMKSNQY EIFFNQSISV KKIILETMPK FEKITEEQDN GKALSKNLIS
660 670 680 690 700
NEPVDLLSDL LGEDSKAESK ASTGDNVKPI DILEEIFGEK NDIAQVPKNA
710 720 730 740 750
NKEESINHSS AVEANSGVTL PLDANKIYDS SSLNVYASLL SANSGLAHLD
760 770 780 790 800
LYFQAKSLIS DLKTFCAVPK AQKLTLGQLY PSSTINASQI CKQSLKISGS
810 820 830
GKLKLRVKLD FHLNGSSSIT NEQFDHKFDE TL
Length:832
Mass (Da):93,624
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABB619E9DC4F565C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95025.1
Z49274 Genomic DNA Translation: CAA89283.1
BK006949 Genomic DNA Translation: DAA11455.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54503

NCBI Reference Sequences

More...
RefSeqi
NP_015354.1, NM_001184126.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR029C_mRNA; YPR029C_mRNA; YPR029C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR029C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95025.1
Z49274 Genomic DNA Translation: CAA89283.1
BK006949 Genomic DNA Translation: DAA11455.1
PIRiS54503
RefSeqiNP_015354.1, NM_001184126.1

3D structure databases

SMRiQ12028
ModBaseiSearch...

Protein-protein interaction databases

BioGridi36207, 180 interactors
ComplexPortaliCPX-532 Adapter complex AP-1
CPX-533 Adapter complex AP-1R
DIPiDIP-3913N
IntActiQ12028, 30 interactors
MINTiQ12028
STRINGi4932.YPR029C

PTM databases

iPTMnetiQ12028

Proteomic databases

MaxQBiQ12028
PaxDbiQ12028
PRIDEiQ12028

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR029C_mRNA; YPR029C_mRNA; YPR029C
GeneIDi856141
KEGGisce:YPR029C

Organism-specific databases

EuPathDBiFungiDB:YPR029C
SGDiS000006233 APL4

Phylogenomic databases

GeneTreeiENSGT00950000182838
HOGENOMiHOG000210271
InParanoidiQ12028
KOiK12391
OMAiQRHRNII

Enzyme and pathway databases

BioCyciYEAST:G3O-34188-MONOMER
ReactomeiR-SCE-432720 Lysosome Vesicle Biogenesis
R-SCE-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12028

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094 AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP1G1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12028
Secondary accession number(s): D6W439
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: June 5, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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