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Entry version 188 (23 Feb 2022)
Sequence version 1 (01 Nov 1996)
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Protein

Midasin

Gene

MDN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (PubMed:15260980, PubMed:15528184, PubMed:19737519, PubMed:20542003).

At an early stage in 60S maturation, mediates the dissociation of the NOP7 complex (YTM1-ERB1-NOP7) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (PubMed:20542003).

Subsequently recruited to the nucleoplasmic particles through interaction with the RIX1 complex. This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (PubMed:26619264).

After remodeling, removes the ribosome biogenesis factor RSA4 in an ATP hydrolysis-driven step from pre-60S ribosomal subunits, rendering them competent for export from the nucleoplasm to the cytoplasm (PubMed:19737519, PubMed:20542003).

Activates the GTPase activity of NOG2, which disengages from the pre-60S particle upon GTP hydrolysis, thus freeing its binding site for the nuclear export factor NMD3 (PubMed:24240281).

6 Publications

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi315 – 322ATPSequence analysis8
Nucleotide bindingi653 – 660ATPSequence analysis8
Nucleotide bindingi1083 – 1090ATPSequence analysis8
Nucleotide bindingi1368 – 1375ATPSequence analysis8
Nucleotide bindingi1747 – 1754ATPSequence analysis8
Nucleotide bindingi2054 – 2061ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Midasin
Alternative name(s):
Dynein-related AAA-ATPase REA1
MIDAS-containing protein
Ribosome export/assembly protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDN1
Synonyms:REA1
Ordered Locus Names:YLR106C
ORF Names:L2901, L8004.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004096, MDN1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YLR106C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963371 – 4910MidasinAdd BLAST4910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1026PhosphothreonineCombined sources1
Modified residuei2971PhosphoserineCombined sources1
Modified residuei4353PhosphoserineCombined sources1
Modified residuei4388PhosphothreonineCombined sources1
Modified residuei4555PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12019

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12019

PRoteomics IDEntifications database

More...
PRIDEi
Q12019

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12019

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with pre-60S ribosomes in the nucleoplasm (PubMed:11583615, PubMed:12374754, PubMed:15260980, PubMed:19737519).

Interacts (via its hexameric AAA ATPase ring) with the RIX1 complex (via RIX1); this interaction is crucial for recruitment of MDN1 to the pre-ribosomal particle (PubMed:15260980, PubMed:26619264).

Interacts (via VWFA/MIDAS domain) with YTM1 (via UBL domain) (PubMed:20542003).

Interacts (via VWFA/MIDAS domain) with RSA4 (via UBL domain) (PubMed:19737519, PubMed:20542003).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31379, 158 interactors

Database of interacting proteins

More...
DIPi
DIP-6285N

Protein interaction database and analysis system

More...
IntActi
Q12019, 43 interactors

Molecular INTeraction database

More...
MINTi
Q12019

STRING: functional protein association networks

More...
STRINGi
4932.YLR106C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12019, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12019

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4704 – 4899VWFAPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni305 – 528AAA-ATPase protomer 1Sequence analysisAdd BLAST224
Regioni636 – 975AAA-ATPase protomer 2Sequence analysisAdd BLAST340
Regioni695 – 803Interaction with RIX11 PublicationAdd BLAST109
Regioni1054 – 1280AAA-ATPase protomer 3Sequence analysisAdd BLAST227
Regioni1345 – 1624AAA-ATPase protomer 4Sequence analysisAdd BLAST280
Regioni1732 – 1985AAA-ATPase protomer 5Sequence analysisAdd BLAST254
Regioni2036 – 2286AAA-ATPase protomer 6Sequence analysisAdd BLAST251
Regioni2372 – 4075Linker1 PublicationAdd BLAST1704
Regioni4045 – 4600DisorderedSequence analysisAdd BLAST556

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4099 – 4152Acidic residuesSequence analysisAdd BLAST54
Compositional biasi4153 – 4205Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi4206 – 4248Acidic residuesSequence analysisAdd BLAST43
Compositional biasi4255 – 4276Acidic residuesSequence analysisAdd BLAST22
Compositional biasi4277 – 4302Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi4303 – 4351Acidic residuesSequence analysisAdd BLAST49
Compositional biasi4352 – 4382Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi4395 – 4430Polar residuesSequence analysisAdd BLAST36
Compositional biasi4431 – 4449Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi4456 – 4497Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi4498 – 4517Polar residuesSequence analysisAdd BLAST20
Compositional biasi4518 – 4556Acidic residuesSequence analysisAdd BLAST39
Compositional biasi4557 – 4598Basic and acidic residuesSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein has several distinct domains, an N-terminal extension (35 kDa), followed by an ATPase domain containing a hexameric ring of six tandem AAA protomers (between 28 and 40 kDa each), a linker domain (260 kDa), an Asp/Glu-rich domain (approximately 70 kDa) and a C-terminal VWFA domain (30 kDa) that possesses a MIDAS (metal ion-dependent adhesion site). The ring-like ATPase head domain associates with the RIX1 complex on the pre-ribosome, while the flexible tail protrudes from the molecule.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the midasin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1808, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000050_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12019

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELGPPNI

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR040848, AAA_lid_7
IPR011704, ATPase_dyneun-rel_AAA
IPR012099, Midasin
IPR041190, Midasin_AAA_lid_5
IPR027417, P-loop_NTPase
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07728, AAA_5, 8 hits
PF17865, AAA_lid_5, 1 hit
PF17867, AAA_lid_7, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010340, Midasin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 6 hits
SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDRILLDL DVVNQRLILF NSAFPSDAIE APFHFSNKES TSENLDNLAG
60 70 80 90 100
TILHSRSITG HVFLYKHIFL EIVARWIKDS KKKDYVLVIE KLASIITIFP
110 120 130 140 150
VAMPLIEDYL DKENDHFITI LQNPSTQKDS DMFKILLAYY RLLYHNKEVF
160 170 180 190 200
ARFIQPDILY QLVDLLTKEQ ENQVVIFLAL KVLSLYLDMG EKTLNDMLDT
210 220 230 240 250
YIKSRDSLLG HFEGDSGIDY SFLELNEAKR CANFSKLPSV PECFTIEKKS
260 270 280 290 300
SYFIIEPQDL STKVASICGV IVPKVHTIHD KVFYPLTFVP THKTVSSLRQ
310 320 330 340 350
LGRKIQNSTP IMLIGKAGSG KTFLINELSK YMGCHDSIVK IHLGEQTDAK
360 370 380 390 400
LLIGTYTSGD KPGTFEWRAG VLATAVKEGR WVLIEDIDKA PTDVLSILLS
410 420 430 440 450
LLEKRELTIP SRGETVKAAN GFQLISTVRI NEDHQKDSSN KIYNLNMIGM
460 470 480 490 500
RIWNVIELEE PSEEDLTHIL AQKFPILTNL IPKLIDSYKN VKSIYMNTKF
510 520 530 540 550
ISLNKGAHTR VVSVRDLIKL CERLDILFKN NGINKPDQLI QSSVYDSIFS
560 570 580 590 600
EAADCFAGAI GEFKALEPII QAIGESLDIA SSRISLFLTQ HVPTLENLDD
610 620 630 640 650
SIKIGRAVLL KEKLNIQKKS MNSTLFAFTN HSLRLMEQIS VCIQMTEPVL
660 670 680 690 700
LVGETGTGKT TVVQQLAKML AKKLTVINVS QQTETGDLLG GYKPVNSKTV
710 720 730 740 750
AVPIQENFET LFNATFSLKK NEKFHKMLHR CFNKNQWKNV VKLWNEAYKM
760 770 780 790 800
AQSILKITNT ENENENAKKK KRRLNTHEKK LLLDKWADFN DSVKKFEAQS
810 820 830 840 850
SSIENSFVFN FVEGSLVKTI RAGEWLLLDE VNLATADTLE SISDLLTEPD
860 870 880 890 900
SRSILLSEKG DAEPIKAHPD FRIFACMNPA TDVGKRDLPM GIRSRFTEIY
910 920 930 940 950
VHSPERDITD LLSIIDKYIG KYSVSDEWVG NDIAELYLEA KKLSDNNTIV
960 970 980 990 1000
DGSNQKPHFS IRTLTRTLLY VTDIIHIYGL RRSLYDGFCM SFLTLLDQKS
1010 1020 1030 1040 1050
EAILKPVIEK FTLGRLKNVK SIMSQTPPSP GPDYVQFKHY WMKKGPNTIQ
1060 1070 1080 1090 1100
EQAHYIITPF VEKNMMNLVR ATSGKRFPVL IQGPTSSGKT SMIKYLADIT
1110 1120 1130 1140 1150
GHKFVRINNH EHTDLQEYLG TYVTDDTGKL SFKEGVLVEA LRKGYWIVLD
1160 1170 1180 1190 1200
ELNLAPTDVL EALNRLLDDN RELFIPETQE VVHPHPDFLL FATQNPPGIY
1210 1220 1230 1240 1250
GGRKILSRAF RNRFLELHFD DIPQDELEII LRERCQIAPS YAKKIVEVYR
1260 1270 1280 1290 1300
QLSIERSASR LFEQKNSFAT LRDLFRWALR DAVGYEQLAA SGYMLLAERC
1310 1320 1330 1340 1350
RTPQEKVTVK KTLEKVMKVK LDMDQYYASL EDKSLEAIGS VTWTKGMRRL
1360 1370 1380 1390 1400
SVLVSSCLKN KEPVLLVGET GCGKTTICQL LAQFMGRELI TLNAHQNTET
1410 1420 1430 1440 1450
GDILGAQRPV RNRSEIQYKL IKSLKTALNI ANDQDVDLKE LLQLYSKSDN
1460 1470 1480 1490 1500
KNIAEDVQLE IQKLRDSLNV LFEWSDGPLI QAMRTGNFFL LDEISLADDS
1510 1520 1530 1540 1550
VLERLNSVLE PERSLLLAEQ GSSDSLVTAS ENFQFFATMN PGGDYGKKEL
1560 1570 1580 1590 1600
SPALRNRFTE IWVPSMEDFN DVNMIVSSRL LEDLKDLANP IVKFSEWFGK
1610 1620 1630 1640 1650
KLGGGNATSG VISLRDILAW VEFINKVFPK IQNKSTALIQ GASMVFIDAL
1660 1670 1680 1690 1700
GTNNTAYLAE NENDLKSLRT ECIIQLLKLC GDDLELQQIE TNEIIVTQDE
1710 1720 1730 1740 1750
LQVGMFKIPR FPDAQSSSFN LTAPTTASNL VRVVRAMQVH KPILLEGSPG
1760 1770 1780 1790 1800
VGKTSLITAL ANITGNKLTR INLSEQTDLV DLFGADAPGE RSGEFLWHDA
1810 1820 1830 1840 1850
PFLRAMKKGE WVLLDEMNLA SQSVLEGLNA CLDHRGEAYI PELDISFSCH
1860 1870 1880 1890 1900
PNFLVFAAQN PQYQGGGRKG LPKSFVNRFS VVFIDMLTSD DLLLIAKHLY
1910 1920 1930 1940 1950
PSIEPDIIAK MIKLMSTLED QVCKRKLWGN SGSPWEFNLR DTLRWLKLLN
1960 1970 1980 1990 2000
QYSICEDVDV FDFVDIIVKQ RFRTISDKNK AQLLIEDIFG KFSTKENFFK
2010 2020 2030 2040 2050
LTEDYVQINN EVALRNPHYR YPITQNLFPL ECNVAVYESV LKAINNNWPL
2060 2070 2080 2090 2100
VLVGPSNSGK TETIRFLASI LGPRVDVFSM NSDIDSMDIL GGYEQVDLTR
2110 2120 2130 2140 2150
QISYITEELT NIVREIISMN MKLSPNATAI MEGLNLLKYL LNNIVTPEKF
2160 2170 2180 2190 2200
QDFRNRFNRF FSHLEGHPLL KTMSMNIEKM TEIITKEASV KFEWFDGMLV
2210 2220 2230 2240 2250
KAVEKGHWLI LDNANLCSPS VLDRLNSLLE IDGSLLINEC SQEDGQPRVL
2260 2270 2280 2290 2300
KPHPNFRLFL TMDPKYGELS RAMRNRGVEI YIDELHSRST AFDRLTLGFE
2310 2320 2330 2340 2350
LGENIDFVSI DDGIKKIKLN EPDMSIPLKH YVPSYLSRPC IFAQVHDILL
2360 2370 2380 2390 2400
LSDEEPIEES LAAVIPISHL GEVGKWANNV LNCTEYSEKK IAERLYVFIT
2410 2420 2430 2440 2450
FLTDMGVLEK INNLYKPANL KFQKALGLHD KQLTEETVSL TLNEYVLPTV
2460 2470 2480 2490 2500
SKYSDKIKSP ESLYLLSSLR LLLNSLNALK LINEKSTHGK IDELTYIELS
2510 2520 2530 2540 2550
AAAFNGRHLK NIPRIPIFCI LYNILTVMSE NLKTESLFCG SNQYQYYWDL
2560 2570 2580 2590 2600
LVIVIAALET AVTKDEARLR VYKELIDSWI ASVKSKSDIE ITPFLNINLE
2610 2620 2630 2640 2650
FTDVLQLSRG HSITLLWDIF RKNYPTTSNS WLAFEKLINL SEKFDKVRLL
2660 2670 2680 2690 2700
QFSESYNSIK DLMDVFRLLN DDVLNNKLSE FNLLLSKLED GINELELISN
2710 2720 2730 2740 2750
KFLNKRKHYF ADEFDNLIRY TFSVDTAELI KELAPASSLA TQKLTKLITN
2760 2770 2780 2790 2800
KYNYPPIFDV LWTEKNAKLT SFTSTIFSSQ FLEDVVRKSN NLKSFSGNQI
2810 2820 2830 2840 2850
KQSISDAELL LSSTIKCSPN LLKSQMEYYK NMLLSWLRKV IDIHVGGDCL
2860 2870 2880 2890 2900
KLTLKELCSL IEEKTASETR VTFAEYIFPA LDLAESSKSL EELGEAWITF
2910 2920 2930 2940 2950
GTGLLLLFVP DSPYDPAIHD YVLYDLFLKT KTFSQNLMKS WRNVRKVISG
2960 2970 2980 2990 3000
DEEIFTEKLI NTISDDDAPQ SPRVYRTGMS IDSLFDEWMA FLSSTMSSRQ
3010 3020 3030 3040 3050
IKELVSSYKC NSDQSDRRLE MLQQNSAHFL NRLESGYSKF ADLNDILAGY
3060 3070 3080 3090 3100
IYSINFGFDL LKLQKSKDRA SFQISPLWSM DPINISCAEN VLSAYHELSR
3110 3120 3130 3140 3150
FFKKGDMEDT SIEKVLMYFL TLFKFHKRDT NLLEIFEAAL YTLYSRWSVR
3160 3170 3180 3190 3200
RFRQEQEENE KSNMFKFNDN SDDYEADFRK LFPDYEDTAL VTNEKDISSP
3210 3220 3230 3240 3250
ENLDDIYFKL ADTYISVFDK DHDANFSSEL KSGAIITTIL SEDLKNTRIE
3260 3270 3280 3290 3300
ELKSGSLSAV INTLDAETQS FKNTEVFGNI DFYHDFSIPE FQKAGDIIET
3310 3320 3330 3340 3350
VLKSVLKLLK QWPEHATLKE LYRVSQEFLN YPIKTPLARQ LQKIEQIYTY
3360 3370 3380 3390 3400
LAEWEKYASS EVSLNNTVKL ITDLIVSWRK LELRTWKGLF NSEDAKTRKS
3410 3420 3430 3440 3450
IGKWWFYLYE SIVISNFVSE KKETAPNATL LVSSLNLFFS KSTLGEFNAR
3460 3470 3480 3490 3500
LDLVKAFYKH IQLIGLRSSK IAGLLHNTIK FYYQFKPLID ERITNGKKSL
3510 3520 3530 3540 3550
EKEIDDIILL ASWKDVNVDA LKQSSRKSHN NLYKIVRKYR DLLNGDAKTI
3560 3570 3580 3590 3600
IEAGLLYSNE NKLKLPTLKQ HFYEDPNLEA SKNLVKEIST WSMRAAPLRN
3610 3620 3630 3640 3650
IDTVASNMDS YLEKISSQEF PNFADLASDF YAEAERLRKE TPNVYTKENK
3660 3670 3680 3690 3700
KRLAYLKTQK SKLLGDALKE LRRIGLKVNF REDIQKVQSS TTTILANIAP
3710 3720 3730 3740 3750
FNNEYLNSSD AFFFKILDLL PKLRSAASNP SDDIPVAAIE RGMALAQSLM
3760 3770 3780 3790 3800
FSLITVRHPL SEFTNDYCKI NGMMLDLEHF TCLKGDIVHS SLKANVDNVR
3810 3820 3830 3840 3850
LFEKWLPSLL DYAAQTLSVI SKYSATSEQQ KILLDAKSTL SSFFVHFNSS
3860 3870 3880 3890 3900
RIFDSSFIES YSRFELFINE LLKKLENAKE TGNAFVFDII IEWIKANKGG
3910 3920 3930 3940 3950
PIKKEQKRGP SVEDVEQAFR RTFTSIILSF QKVIGDGIES ISETDDNWLS
3960 3970 3980 3990 4000
ASFKKVMVNV KLLRSSVVSK NIETALSLLK DFDFTTTESI YVKSVISFTL
4010 4020 4030 4040 4050
PVITRYYNAM TVVLERSRIY YTNTSRGMYI LSTILHSLAK NGFCSPQPPS
4060 4070 4080 4090 4100
EEVDDKNLQE GTGLGDGEGA QNNNKDVEQD EDLTEDAQNE NKEQQDKDER
4110 4120 4130 4140 4150
DDENEDDAVE MEGDMAGELE DLSNGEENDD EDTDSEEEEL DEEIDDLNED
4160 4170 4180 4190 4200
DPNAIDDKMW DDKASDNSKE KDTDQNLDGK NQEEDVQAAE NDEQQRDNKE
4210 4220 4230 4240 4250
GGDEDPNAPE DGDEEIENDE NAEEENDVGE QEDEVKDEEG EDLEANVPEI
4260 4270 4280 4290 4300
ETLDLPEDMN LDSEHEESDE DVDMSDGMPD DLNKEEVGNE DEEVKQESGI
4310 4320 4330 4340 4350
ESDNENDEPG PEEDAGETET ALDEEEGAEE DVDMTNDEGK EDEENGPEEQ
4360 4370 4380 4390 4400
AMSDEEELKQ DAAMEENKEK GGEQNTEGLD GVEEKADTED IDQEAAVQQD
4410 4420 4430 4440 4450
SGSKGAGADA TDTQEQDDVG GSGTTQNTYE EDQEDVTKNN EESREEATAA
4460 4470 4480 4490 4500
LKQLGDSMKE YHRRRQDIKE AQTNGEEDEN LEKNNERPDE FEHVEGANTE
4510 4520 4530 4540 4550
TDTQALGSAT QDQLQTIDED MAIDDDREEQ EVDQKELVED ADDEKMDIDE
4560 4570 4580 4590 4600
EEMLSDIDAH DANNDVDSKK SGFIGKRKSE EDFENELSNE HFSADQEDDS
4610 4620 4630 4640 4650
EIQSLIENIE DNPPDASASL TPERSLEESR ELWHKSEIST ADLVSRLGEQ
4660 4670 4680 4690 4700
LRLILEPTLA TKLKGDYKTG KRLNMKRIIP YIASQFRKDK IWLRRTKPSK
4710 4720 4730 4740 4750
RQYQIMIALD DSKSMSESKC VKLAFDSLCL VSKTLTQLEA GGLSIVKFGE
4760 4770 4780 4790 4800
NIKEVHSFDQ QFSNESGARA FQWFGFQETK TDVKKLVAES TKIFERARAM
4810 4820 4830 4840 4850
VHNDQWQLEI VISDGICEDH ETIQKLVRRA RENKIMLVFV IIDGITSNES
4860 4870 4880 4890 4900
ILDMSQVNYI PDQYGNPQLK ITKYLDTFPF EFYVVVHDIS ELPEMLSLIL
4910
RQYFTDLASS
Length:4,910
Mass (Da):559,308
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4E873BEDF6E1E5B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U53876 Genomic DNA Translation: AAB67548.1
Z73278 Genomic DNA Translation: CAA97671.1
X89514 Genomic DNA Translation: CAA61684.1
Z73279 Genomic DNA Translation: CAA97673.1
BK006945 Genomic DNA Translation: DAA09422.1

Protein sequence database of the Protein Information Resource

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PIRi
S64942

NCBI Reference Sequences

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RefSeqi
NP_013207.1, NM_001181993.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YLR106C_mRNA; YLR106C; YLR106C

Database of genes from NCBI RefSeq genomes

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GeneIDi
850796

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR106C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53876 Genomic DNA Translation: AAB67548.1
Z73278 Genomic DNA Translation: CAA97671.1
X89514 Genomic DNA Translation: CAA61684.1
Z73279 Genomic DNA Translation: CAA97673.1
BK006945 Genomic DNA Translation: DAA09422.1
PIRiS64942
RefSeqiNP_013207.1, NM_001181993.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FL8electron microscopy9.50s1-4910[»]
5JCSelectron microscopy9.50s1-4910[»]
6HYDelectron microscopy3.90A2356-4041[»]
6HYPelectron microscopy4.40A238-4910[»]
6I26electron microscopy4.30A238-4910[»]
6I27electron microscopy7.80A238-4910[»]
6YLFelectron microscopy4.20AP11-4910[»]
6YLHelectron microscopy3.10v1-4910[»]
SMRiQ12019
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31379, 158 interactors
DIPiDIP-6285N
IntActiQ12019, 43 interactors
MINTiQ12019
STRINGi4932.YLR106C

PTM databases

iPTMnetiQ12019

Proteomic databases

MaxQBiQ12019
PaxDbiQ12019
PRIDEiQ12019

Genome annotation databases

EnsemblFungiiYLR106C_mRNA; YLR106C; YLR106C
GeneIDi850796
KEGGisce:YLR106C

Organism-specific databases

SGDiS000004096, MDN1
VEuPathDBiFungiDB:YLR106C

Phylogenomic databases

eggNOGiKOG1808, Eukaryota
GeneTreeiENSGT00550000074802
HOGENOMiCLU_000050_0_2_1
InParanoidiQ12019
OMAiELGPPNI

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q12019
RNActiQ12019, protein

Family and domain databases

Gene3Di3.40.50.300, 6 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR040848, AAA_lid_7
IPR011704, ATPase_dyneun-rel_AAA
IPR012099, Midasin
IPR041190, Midasin_AAA_lid_5
IPR027417, P-loop_NTPase
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF07728, AAA_5, 8 hits
PF17865, AAA_lid_5, 1 hit
PF17867, AAA_lid_7, 3 hits
PIRSFiPIRSF010340, Midasin, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 6 hits
SUPFAMiSSF52540, SSF52540, 6 hits
SSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234, VWFA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDN1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12019
Secondary accession number(s): D6VYA6, Q7LGX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1996
Last modified: February 23, 2022
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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