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UniProtKB - Q11PP7 (KMO_CYTH3)
Protein
Kynurenine 3-monooxygenase
Gene
kmo
Organism
Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465)
Status
Functioni
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
UniRule annotation1 PublicationCatalytic activityi
- H+ + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+UniRule annotation1 PublicationEC:1.14.13.9UniRule annotation1 Publication
Cofactori
FADUniRule annotation
Kineticsi
- KM=76 µM for L-kynurenine1 Publication
- KM=89 µM for NADPH1 Publication
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- FAD binding Source: InterPro
- kynurenine 3-monooxygenase activity Source: UniProtKB-UniRule
GO - Biological processi
- 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-UniRule
- anthranilate metabolic process Source: UniProtKB-UniRule
- quinolinate biosynthetic process Source: UniProtKB-UniRule
- tryptophan catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Pyridine nucleotide biosynthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
BRENDAi | 1.14.13.9, 7214 |
SABIO-RKi | Q11PP7 |
UniPathwayi | UPA00253;UER00328 |
Names & Taxonomyi
Protein namesi | Recommended name: Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)Alternative name(s): Kynurenine 3-hydroxylaseUniRule annotation |
Gene namesi | Name:kmoUniRule annotation Ordered Locus Names:CHU_3380 |
Organismi | Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) |
Taxonomic identifieri | 269798 [NCBI] |
Taxonomic lineagei | Bacteria › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Cytophaga › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000361935 | 1 – 449 | Kynurenine 3-monooxygenaseAdd BLAST | 449 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0654, Bacteria |
HOGENOMi | CLU_023210_0_1_10 |
OMAi | REFMFIA |
OrthoDBi | 504558at2 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
HAMAPi | MF_01971, Kynurenine_monooxygenase, 1 hit |
InterProi | View protein in InterPro IPR002938, FAD-bd IPR036188, FAD/NAD-bd_sf IPR027545, Kynurenine_monooxygenase |
Pfami | View protein in Pfam PF01494, FAD_binding_3, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
i Sequence
Sequence statusi: Complete.
Q11PP7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEQITICGA GLVGSLLAVY LIERGFSVRV FEKRKDPRKN EADAGRSINL
60 70 80 90 100
AISHRGIHAL KDAQTGLEKE ALKLAVPMYG RAIHDLHGHV SFQAYGEASQ
110 120 130 140 150
HINSIGRGAL NKLLITTAEN LGVHFLFEHT CTDYHAAGEQ WLFSDITGNT
160 170 180 190 200
VATQSKEIVI GADGAFSIVR SFLSKQQQPQ PQIETLEYGY KELEIASAHT
210 220 230 240 250
ETITNNQALH IWPRERFMLI ALPNEDGSYT ATLFLPLKGE ISFEALQSDQ
260 270 280 290 300
DIQLFFKKYF PDTENLFPDL TEQFYRHPTS KLFTIHSSNW FNAHTLLIGD
310 320 330 340 350
AAHALVPFYG QGMNAGFEDC RILAEIIDGK SKTNWSEIFA EFYNQRKENA
360 370 380 390 400
DAISDLALQN FIEMRDHVAD ASFLLRKKIE KHLHQELEDA FIPQYTMVSF
410 420 430 440
TDISYKEAME TGLLHQKILD EIMAIPDIEA AWPTEELKNK VITVTKKYI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000383 Genomic DNA Translation: ABG60616.1 |
RefSeqi | WP_011586724.1, NZ_FPJX01000012.1 |
Genome annotation databases
EnsemblBacteriai | ABG60616; ABG60616; CHU_3380 |
KEGGi | chu:CHU_3380 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000383 Genomic DNA Translation: ABG60616.1 |
RefSeqi | WP_011586724.1, NZ_FPJX01000012.1 |
3D structure databases
AlphaFoldDBi | Q11PP7 |
SMRi | Q11PP7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 269798.CHU_3380 |
Protocols and materials databases
DNASUi | 4187169 |
Genome annotation databases
EnsemblBacteriai | ABG60616; ABG60616; CHU_3380 |
KEGGi | chu:CHU_3380 |
Phylogenomic databases
eggNOGi | COG0654, Bacteria |
HOGENOMi | CLU_023210_0_1_10 |
OMAi | REFMFIA |
OrthoDBi | 504558at2 |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00328 |
BRENDAi | 1.14.13.9, 7214 |
SABIO-RKi | Q11PP7 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
HAMAPi | MF_01971, Kynurenine_monooxygenase, 1 hit |
InterProi | View protein in InterPro IPR002938, FAD-bd IPR036188, FAD/NAD-bd_sf IPR027545, Kynurenine_monooxygenase |
Pfami | View protein in Pfam PF01494, FAD_binding_3, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KMO_CYTH3 | |
Accessioni | Q11PP7Primary (citable) accession number: Q11PP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 10, 2009 |
Last sequence update: | August 22, 2006 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families