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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi261Manganese 2UniRule annotation1
Metal bindingi266Manganese 1UniRule annotation1
Metal bindingi266Manganese 2UniRule annotation1
Active sitei273UniRule annotation1
Metal bindingi284Manganese 2UniRule annotation1
Metal bindingi343Manganese 1UniRule annotation1
Metal bindingi345Manganese 1UniRule annotation1
Metal bindingi345Manganese 2UniRule annotation1
Active sitei347UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:Meso_1756
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
Proteomesi
  • UP000001820 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000199331 – 495Probable cytosol aminopeptidaseAdd BLAST495

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_1756

Structurei

3D structure databases

ProteinModelPortaliQ11HH5
SMRiQ11HH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ6 Bacteria
COG0260 LUCA
HOGENOMiHOG000243129
KOiK01255
OMAiMKNTGPR
OrthoDBiPOG091H01BT

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00181 Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept
IPR008283 Peptidase_M17_N
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PF02789 Peptidase_M17_N, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

Sequencei

Sequence statusi: Complete.

Q11HH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEKPTIAFA KFAAPKKGSV ILLVPEGGNL GQAATAADPA GVMPKVFAAA
60 70 80 90 100
EFKGKLAATV EALAPQGTAY DRVAVIGTGN PSALTEQSWL QIGGAAAAAA
110 120 130 140 150
KNAGEVTVIA DVAGLELSAR EAANIGLGIL LRSYVFDKYK TRRDENGIKA
160 170 180 190 200
RDKKFTIQCA DPNAAKKAFA EASALGDGVY LARDLVNEPA NVLGPVEFAA
210 220 230 240 250
QAKALESLGV KVDVLTEREM KKLGMGALLG VAQGSVRPPR LVVMQWNGGK
260 270 280 290 300
PKQKPVAFVG KGVVFDTGGI SIKPAASMED MKGDMAGAAA VVGLMHALAA
310 320 330 340 350
RKAKTNAVGI IGLVENMPDG NAQRPGDIVT SMSGQTIEII NTDAEGRLVL
360 370 380 390 400
ADALWYCKEQ FKPQFMVNLA TLTGAIIVAL GNSHAGLFSN DDTLSERLTA
410 420 430 440 450
AGQATGEKVW RMPLGSEYDK LIDTKNADMK NTGGRQAGSI TAAQFLKRFV
460 470 480 490
DDTPWAHLDV AGTAMGSPSS EINQSWASGF GVRLLDRLVA DHYEG
Length:495
Mass (Da):51,693
Last modified:August 22, 2006 - v1
Checksum:iC015EB1A9A525EC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA Translation: ABG63150.1
RefSeqiWP_011581093.1, NC_008254.1

Genome annotation databases

EnsemblBacteriaiABG63150; ABG63150; Meso_1756
KEGGimes:Meso_1756

Similar proteinsi

Entry informationi

Entry nameiAMPA_CHESB
AccessioniPrimary (citable) accession number: Q11HH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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