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Protein

Argininosuccinate synthase

Gene

argG

Organism
Trichodesmium erythraeum (strain IMS101)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei89CitrullineUniRule annotation1
Binding sitei119ATP; via amide nitrogenUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei125AspartateUniRule annotation1
Binding sitei125CitrullineUniRule annotation1
Binding sitei126AspartateUniRule annotation1
Binding sitei129CitrullineUniRule annotation1
Binding sitei177CitrullineUniRule annotation1
Binding sitei262CitrullineUniRule annotation1
Binding sitei274CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTERY203124:G1G6S-882-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Tery_0882
OrganismiTrichodesmium erythraeum (strain IMS101)
Taxonomic identifieri203124 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesMicrocoleaceaeTrichodesmium
Proteomesi
  • UP000008878 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002639921 – 400Argininosuccinate synthaseAdd BLAST400

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi203124.Tery_0882

Structurei

3D structure databases

ProteinModelPortaliQ117P0
SMRiQ117P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q117P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRATKVVLA YSGGVDTSVC IPYLKNEWGV KEVITLAADL GQGDELEGVR
60 70 80 90 100
KKALDSGAVE SLVIDVIEPL IKEYAFPAIQ ANALYENRYP LATALARPLI
110 120 130 140 150
AKILVEAAEK YGADAIAHGC TGKGNDQVRF DVAIAALNPQ IKILAPAREW
160 170 180 190 200
GMSREETIAY GEEYGIPAPV KKSSPYSIDK NLLGMAIEAG ELEDPWVEPP
210 220 230 240 250
EEVYGMTKAI ADTPNEPEYI EIGFERGIPV SLNGQEMGGI ELITKLNQIA
260 270 280 290 300
GNHGIGRIDM IENRLVGIKS REIYESPAMW VLIQGHRDLE SLTLTADVTR
310 320 330 340 350
YKRGIEETYS QLVYNGLWFS PLKGALDAFI QQTQERVTGV VRVKLFKGNA
360 370 380 390 400
MVVGRKSDNS LYSFDLATYG AEDEFDHKAA EGFIYVWGLP TRVWSEKLRG
Length:400
Mass (Da):44,032
Last modified:August 22, 2006 - v1
Checksum:i5C22B10E1AC3959F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000393 Genomic DNA Translation: ABG50284.1
RefSeqiWP_011610675.1, NC_008312.1

Genome annotation databases

EnsemblBacteriaiABG50284; ABG50284; Tery_0882
KEGGiter:Tery_0882

Similar proteinsi

Entry informationi

Entry nameiASSY_TRIEI
AccessioniPrimary (citable) accession number: Q117P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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