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Entry version 182 (02 Jun 2021)
Sequence version 1 (01 Oct 1996)
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Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Gene

ST3GAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500).

Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500).

Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity).

Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912).

Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity).

In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606).

Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity).

Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.2 mM for Gal-beta-1,3-GalNAc1 Publication
  2. KM=0.3 mM for Gal-beta-1,4-GlcNAc1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    Pathwayi: Glycolipid biosynthesis

    This protein is involved in Glycolipid biosynthesis.1 Publication
    View all proteins of this organism that are known to be involved in Glycolipid biosynthesis.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    Biological processLipid metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS03285-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.99.2, 2681
    2.4.99.6, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q11206

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1912420, Pre-NOTCH Processing in Golgi
    R-HSA-2022854, Keratan sulfate biosynthesis
    R-HSA-4085001, Sialic acid metabolism
    R-HSA-9037629, Lewis blood group biosynthesis
    R-HSA-9683673, Maturation of protein 3a
    R-HSA-9694548, Maturation of spike protein
    R-HSA-9694719, Maturation of protein 3a
    R-HSA-975577, N-Glycan antennae elongation
    R-HSA-977068, Termination of O-glycan biosynthesis

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q11206

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00378

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT29, Glycosyltransferase Family 29

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001384

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC:2.4.99.21 Publication, EC:2.4.99.41 Publication)
    Short name:
    Alpha 2,3-ST 4
    Short name:
    Beta-galactoside alpha-2,3-sialyltransferase 4
    Alternative name(s):
    Alpha 2,3-sialyltransferase IV
    Gal-NAc6S
    Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase1 Publication
    Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase1 Publication
    N-acetyllactosaminide alpha-2,3-sialyltransferase (EC:2.4.99.62 Publications)
    SAT-31 Publication
    ST-4
    ST3Gal IV
    Short name:
    ST3GalIV
    ST3GalA.2
    STZ1 Publication
    Sialyltransferase 4C
    Short name:
    SIAT4-C
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ST3GAL4
    Synonyms:CGS23, NANTA3, SIAT4C, STZ
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10864, ST3GAL4

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    104240, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q11206

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000110080.18

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicSequence analysis8
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
    Topological domaini27 – 333LumenalSequence analysisAdd BLAST307

    Keywords - Cellular componenti

    Golgi apparatus, Membrane, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    6484

    Open Targets

    More...
    OpenTargetsi
    ENSG00000110080

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35766

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q11206, Tbio

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ST3GAL4

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001492621 – 333CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4Add BLAST333

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi120 ↔ 273By similarity
    Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    The soluble form derives from the membrane form by proteolytic processing.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q11206

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q11206

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q11206

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q11206

    PeptideAtlas

    More...
    PeptideAtlasi
    Q11206

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q11206

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    58900 [Q11206-1]
    58901 [Q11206-2]
    58902 [Q11206-3]
    58903 [Q11206-4]
    58904 [Q11206-5]
    72151

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    Q11206, 4 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q11206

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q11206

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in adult placenta, heart and kidney.1 Publication

    <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expressed in fetal tissues, with highest levels in heart, lung, and kidney.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000110080, Expressed in left adrenal gland and 221 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q11206, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q11206, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000110080, Tissue enhanced (placenta)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    112377, 25 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q11206, 13 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000436047

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q11206, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2692, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158893

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_032020_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q11206

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SIHYYEY

    Database of Orthologous Groups

    More...
    OrthoDBi
    891104at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q11206

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF354325

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.1480.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf
    IPR012163, Sialyl_trans

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00777, Glyco_transf_29, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF005557, Sialyl_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 7 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q11206-1) [UniParc]FASTAAdd to basket
    Also known as: B1

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MVSKSRWKLL AMLALVLVVM VWYSISREDR YIELFYFPIP EKKEPCLQGE
    60 70 80 90 100
    AESKASKLFG NYSRDQPIFL RLEDYFWVKT PSAYELPYGT KGSEDLLLRV
    110 120 130 140 150
    LAITSSSIPK NIQSLRCRRC VVVGNGHRLR NSSLGDAINK YDVVIRLNNA
    160 170 180 190 200
    PVAGYEGDVG SKTTMRLFYP ESAHFDPKVE NNPDTLLVLV AFKAMDFHWI
    210 220 230 240 250
    ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA ADKLLSLPMQ
    260 270 280 290 300
    QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT
    310 320 330
    LKSMAGSGHN VSQEALAIKR MLEMGAIKNL TSF
    Length:333
    Mass (Da):38,045
    Last modified:October 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15E4BCE1F4F5B3C3
    GO
    Isoform 2 (identifier: Q11206-2) [UniParc]FASTAAdd to basket
    Also known as: A1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MVSKSR → MCPAG

    Show »
    Length:332
    Mass (Da):37,816
    Checksum:i3FF1B2BBAF273A03
    GO
    Isoform 3 (identifier: Q11206-3) [UniParc]FASTAAdd to basket
    Also known as: A2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.

    Show »
    Length:322
    Mass (Da):36,745
    Checksum:i3AA7031A765DF2BD
    GO
    Isoform 4 (identifier: Q11206-4) [UniParc]FASTAAdd to basket
    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         61-61: N → KLSPLCS

    Show »
    Length:339
    Mass (Da):38,660
    Checksum:iF48917FF5E9CAF87
    GO
    Isoform 5 (identifier: Q11206-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         30-34: RYIEL → S

    Show »
    Length:329
    Mass (Da):37,458
    Checksum:i3A1C52816B5BE9E8
    GO
    Isoform 6 (identifier: Q11206-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MVSKSR → MCPAG
         30-34: RYIEL → S

    Show »
    Length:328
    Mass (Da):37,228
    Checksum:i11CEDB415E141CDD
    GO
    Isoform 7 (identifier: Q11206-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.
         30-34: RYIEL → S

    Show »
    Length:318
    Mass (Da):36,157
    Checksum:iB8B413FF58A693F8
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PQZ2E9PQZ2_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    209Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PMC7E9PMC7_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    153Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V5F3A0A7I2V5F3_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    350Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V4V4A0A7I2V4V4_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    354Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V4R4A0A7I2V4R4_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    264Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V2H5A0A7I2V2H5_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    181Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V4F4A0A7I2V4F4_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    331Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PNJ9E9PNJ9_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    93Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PN64E9PN64_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    126Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PPJ6E9PPJ6_HUMAN
    CMP-N-acetylneuraminate-beta-galact...
    ST3GAL4
    111Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182 – 183NP → KG in AAC14162 (PubMed:8611500).Curated2
    Sequence conflicti200I → T in AAC14162 (PubMed:8611500).Curated1
    Sequence conflicti304M → I in AAC14162 (PubMed:8611500).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0017851 – 11Missing in isoform 3 and isoform 7. 1 PublicationAdd BLAST11
    Alternative sequenceiVSP_0017841 – 6MVSKSR → MCPAG in isoform 2 and isoform 6. 2 Publications6
    Alternative sequenceiVSP_02110430 – 34RYIEL → S in isoform 5, isoform 6 and isoform 7. 2 Publications5
    Alternative sequenceiVSP_00178661N → KLSPLCS in isoform 4. 2 Publications1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L23767 mRNA Translation: AAA16460.1
    X74570 mRNA Translation: CAA52662.1
    AF516603 mRNA Translation: AAM66432.1
    AF516604 mRNA Translation: AAM66433.1
    AY040826 mRNA Translation: AAK93790.1
    AK291577 mRNA Translation: BAF84266.1
    AP000806 Genomic DNA No translation available.
    AP001318 Genomic DNA No translation available.
    BC010645 mRNA Translation: AAH10645.1
    AF035249 mRNA Translation: AAC14162.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS58193.1 [Q11206-1]
    CCDS58194.1 [Q11206-2]
    CCDS8474.1 [Q11206-5]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A48715
    A49879

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001241686.1, NM_001254757.1 [Q11206-1]
    NP_001241687.1, NM_001254758.1 [Q11206-1]
    NP_001241688.1, NM_001254759.1 [Q11206-2]
    NP_001335328.1, NM_001348399.1 [Q11206-1]
    NP_001335329.1, NM_001348400.1 [Q11206-5]
    NP_006269.1, NM_006278.2 [Q11206-5]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000227495; ENSP00000227495; ENSG00000110080 [Q11206-5]
    ENST00000392669; ENSP00000376437; ENSG00000110080 [Q11206-1]
    ENST00000444328; ENSP00000394354; ENSG00000110080 [Q11206-1]
    ENST00000449406; ENSP00000399444; ENSG00000110080 [Q11206-3]
    ENST00000526727; ENSP00000436047; ENSG00000110080 [Q11206-1]
    ENST00000530591; ENSP00000433989; ENSG00000110080 [Q11206-5]
    ENST00000532243; ENSP00000434349; ENSG00000110080 [Q11206-2]
    ENST00000534083; ENSP00000433318; ENSG00000110080 [Q11206-1]
    ENST00000534457; ENSP00000434668; ENSG00000110080 [Q11206-6]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    6484

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:6484

    UCSC genome browser

    More...
    UCSCi
    uc001qds.4, human [Q11206-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Functional Glycomics Gateway - GTase

    ST3Gal IV

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L23767 mRNA Translation: AAA16460.1
    X74570 mRNA Translation: CAA52662.1
    AF516603 mRNA Translation: AAM66432.1
    AF516604 mRNA Translation: AAM66433.1
    AY040826 mRNA Translation: AAK93790.1
    AK291577 mRNA Translation: BAF84266.1
    AP000806 Genomic DNA No translation available.
    AP001318 Genomic DNA No translation available.
    BC010645 mRNA Translation: AAH10645.1
    AF035249 mRNA Translation: AAC14162.1
    CCDSiCCDS58193.1 [Q11206-1]
    CCDS58194.1 [Q11206-2]
    CCDS8474.1 [Q11206-5]
    PIRiA48715
    A49879
    RefSeqiNP_001241686.1, NM_001254757.1 [Q11206-1]
    NP_001241687.1, NM_001254758.1 [Q11206-1]
    NP_001241688.1, NM_001254759.1 [Q11206-2]
    NP_001335328.1, NM_001348399.1 [Q11206-1]
    NP_001335329.1, NM_001348400.1 [Q11206-5]
    NP_006269.1, NM_006278.2 [Q11206-5]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi112377, 25 interactors
    IntActiQ11206, 13 interactors
    STRINGi9606.ENSP00000436047

    Chemistry databases

    SwissLipidsiSLP:000001384

    Protein family/group databases

    CAZyiGT29, Glycosyltransferase Family 29

    PTM databases

    GlyGeniQ11206, 4 sites
    iPTMnetiQ11206
    PhosphoSitePlusiQ11206

    Genetic variation databases

    BioMutaiST3GAL4

    Proteomic databases

    jPOSTiQ11206
    MassIVEiQ11206
    MaxQBiQ11206
    PaxDbiQ11206
    PeptideAtlasiQ11206
    PRIDEiQ11206
    ProteomicsDBi58900 [Q11206-1]
    58901 [Q11206-2]
    58902 [Q11206-3]
    58903 [Q11206-4]
    58904 [Q11206-5]
    72151

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    33000, 161 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    6484

    Genome annotation databases

    EnsembliENST00000227495; ENSP00000227495; ENSG00000110080 [Q11206-5]
    ENST00000392669; ENSP00000376437; ENSG00000110080 [Q11206-1]
    ENST00000444328; ENSP00000394354; ENSG00000110080 [Q11206-1]
    ENST00000449406; ENSP00000399444; ENSG00000110080 [Q11206-3]
    ENST00000526727; ENSP00000436047; ENSG00000110080 [Q11206-1]
    ENST00000530591; ENSP00000433989; ENSG00000110080 [Q11206-5]
    ENST00000532243; ENSP00000434349; ENSG00000110080 [Q11206-2]
    ENST00000534083; ENSP00000433318; ENSG00000110080 [Q11206-1]
    ENST00000534457; ENSP00000434668; ENSG00000110080 [Q11206-6]
    GeneIDi6484
    KEGGihsa:6484
    UCSCiuc001qds.4, human [Q11206-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6484
    DisGeNETi6484

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ST3GAL4
    HGNCiHGNC:10864, ST3GAL4
    HPAiENSG00000110080, Tissue enhanced (placenta)
    MIMi104240, gene
    neXtProtiNX_Q11206
    OpenTargetsiENSG00000110080
    PharmGKBiPA35766
    VEuPathDBiHostDB:ENSG00000110080.18

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2692, Eukaryota
    GeneTreeiENSGT00940000158893
    HOGENOMiCLU_032020_1_0_1
    InParanoidiQ11206
    OMAiSIHYYEY
    OrthoDBi891104at2759
    PhylomeDBiQ11206
    TreeFamiTF354325

    Enzyme and pathway databases

    UniPathwayiUPA00378
    BioCyciMetaCyc:HS03285-MONOMER
    BRENDAi2.4.99.2, 2681
    2.4.99.6, 2681
    PathwayCommonsiQ11206
    ReactomeiR-HSA-1912420, Pre-NOTCH Processing in Golgi
    R-HSA-2022854, Keratan sulfate biosynthesis
    R-HSA-4085001, Sialic acid metabolism
    R-HSA-9037629, Lewis blood group biosynthesis
    R-HSA-9683673, Maturation of protein 3a
    R-HSA-9694548, Maturation of spike protein
    R-HSA-9694719, Maturation of protein 3a
    R-HSA-975577, N-Glycan antennae elongation
    R-HSA-977068, Termination of O-glycan biosynthesis
    SIGNORiQ11206

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    6484, 7 hits in 993 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ST3GAL4, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ST3GAL4

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    6484
    PharosiQ11206, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q11206
    RNActiQ11206, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000110080, Expressed in left adrenal gland and 221 other tissues
    ExpressionAtlasiQ11206, baseline and differential
    GenevisibleiQ11206, HS

    Family and domain databases

    Gene3Di3.90.1480.20, 1 hit
    InterProiView protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf
    IPR012163, Sialyl_trans
    PfamiView protein in Pfam
    PF00777, Glyco_transf_29, 1 hit
    PIRSFiPIRSF005557, Sialyl_trans, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIA4C_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q11206
    Secondary accession number(s): A8K6B2
    , O60497, Q8N6A6, Q8NFG7, Q96QQ9
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: June 2, 2021
    This is version 182 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families
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