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Entry version 177 (12 Aug 2020)
Sequence version 1 (01 Oct 1996)
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Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Gene

ST3GAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03285-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.99.4, 2681
2.4.99.6, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q11206

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1912420, Pre-NOTCH Processing in Golgi
R-HSA-2022854, Keratan sulfate biosynthesis
R-HSA-4085001, Sialic acid metabolism
R-HSA-9037629, Lewis blood group biosynthesis
R-HSA-975577, N-Glycan antennae elongation
R-HSA-977068, Termination of O-glycan biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q11206

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT29, Glycosyltransferase Family 29

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001384

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC:2.4.99.2By similarity, EC:2.4.99.4By similarity)
Short name:
Alpha 2,3-ST 4
Short name:
Beta-galactoside alpha-2,3-sialyltransferase 4
Alternative name(s):
Alpha 2,3-sialyltransferase IV
Gal-NAc6S
Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
SAT-3
ST-4
ST3Gal IV
Short name:
ST3GalIV
ST3GalA.2
STZ
Sialyltransferase 4C
Short name:
SIAT4-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ST3GAL4
Synonyms:CGS23, NANTA3, SIAT4C, STZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110080.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10864, ST3GAL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104240, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q11206

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini27 – 333LumenalSequence analysisAdd BLAST307

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6484

Open Targets

More...
OpenTargetsi
ENSG00000110080

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35766

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q11206, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ST3GAL4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001492621 – 333CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi120 ↔ 273By similarity
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q11206

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q11206

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q11206

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q11206

PeptideAtlas

More...
PeptideAtlasi
Q11206

PRoteomics IDEntifications database

More...
PRIDEi
Q11206

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58900 [Q11206-1]
58901 [Q11206-2]
58902 [Q11206-3]
58903 [Q11206-4]
58904 [Q11206-5]
72151

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q11206, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q11206

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q11206

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult placenta, ovary and testes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110080, Expressed in left adrenal gland and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q11206, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q11206, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110080, Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112377, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q11206, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000436047

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q11206, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2692, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158893

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032020_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q11206

KEGG Orthology (KO)

More...
KOi
K03494

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIHYYEY

Database of Orthologous Groups

More...
OrthoDBi
891104at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q11206

TreeFam database of animal gene trees

More...
TreeFami
TF354325

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1480.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001675, Glyco_trans_29
IPR038578, GT29-like_sf
IPR012163, Sialyl_trans

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00777, Glyco_transf_29, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005557, Sialyl_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q11206-1) [UniParc]FASTAAdd to basket
Also known as: B1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSKSRWKLL AMLALVLVVM VWYSISREDR YIELFYFPIP EKKEPCLQGE
60 70 80 90 100
AESKASKLFG NYSRDQPIFL RLEDYFWVKT PSAYELPYGT KGSEDLLLRV
110 120 130 140 150
LAITSSSIPK NIQSLRCRRC VVVGNGHRLR NSSLGDAINK YDVVIRLNNA
160 170 180 190 200
PVAGYEGDVG SKTTMRLFYP ESAHFDPKVE NNPDTLLVLV AFKAMDFHWI
210 220 230 240 250
ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA ADKLLSLPMQ
260 270 280 290 300
QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT
310 320 330
LKSMAGSGHN VSQEALAIKR MLEMGAIKNL TSF
Length:333
Mass (Da):38,045
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15E4BCE1F4F5B3C3
GO
Isoform 2 (identifier: Q11206-2) [UniParc]FASTAAdd to basket
Also known as: A1

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MVSKSR → MCPAG

Show »
Length:332
Mass (Da):37,816
Checksum:i3FF1B2BBAF273A03
GO
Isoform 3 (identifier: Q11206-3) [UniParc]FASTAAdd to basket
Also known as: A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:322
Mass (Da):36,745
Checksum:i3AA7031A765DF2BD
GO
Isoform 4 (identifier: Q11206-4) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: N → KLSPLCS

Show »
Length:339
Mass (Da):38,660
Checksum:iF48917FF5E9CAF87
GO
Isoform 5 (identifier: Q11206-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-34: RYIEL → S

Show »
Length:329
Mass (Da):37,458
Checksum:i3A1C52816B5BE9E8
GO
Isoform 6 (identifier: Q11206-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MVSKSR → MCPAG
     30-34: RYIEL → S

Show »
Length:328
Mass (Da):37,228
Checksum:i11CEDB415E141CDD
GO
Isoform 7 (identifier: Q11206-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.
     30-34: RYIEL → S

Show »
Length:318
Mass (Da):36,157
Checksum:iB8B413FF58A693F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQZ2E9PQZ2_HUMAN
CMP-N-acetylneuraminate-beta-galact...
ST3GAL4
209Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMC7E9PMC7_HUMAN
CMP-N-acetylneuraminate-beta-galact...
ST3GAL4
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNJ9E9PNJ9_HUMAN
CMP-N-acetylneuraminate-beta-galact...
ST3GAL4
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPJ6E9PPJ6_HUMAN
CMP-N-acetylneuraminate-beta-galact...
ST3GAL4
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN64E9PN64_HUMAN
CMP-N-acetylneuraminate-beta-galact...
ST3GAL4
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKJ2E9PKJ2_HUMAN
CMP-N-acetylneuraminate-beta-galact...
ST3GAL4
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182 – 183NP → KG in AAC14162 (PubMed:8611500).Curated2
Sequence conflicti200I → T in AAC14162 (PubMed:8611500).Curated1
Sequence conflicti304M → I in AAC14162 (PubMed:8611500).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0017851 – 11Missing in isoform 3 and isoform 7. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0017841 – 6MVSKSR → MCPAG in isoform 2 and isoform 6. 2 Publications6
Alternative sequenceiVSP_02110430 – 34RYIEL → S in isoform 5, isoform 6 and isoform 7. 2 Publications5
Alternative sequenceiVSP_00178661N → KLSPLCS in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L23767 mRNA Translation: AAA16460.1
X74570 mRNA Translation: CAA52662.1
AF516603 mRNA Translation: AAM66432.1
AF516604 mRNA Translation: AAM66433.1
AY040826 mRNA Translation: AAK93790.1
AK291577 mRNA Translation: BAF84266.1
AP000806 Genomic DNA No translation available.
AP001318 Genomic DNA No translation available.
BC010645 mRNA Translation: AAH10645.1
AF035249 mRNA Translation: AAC14162.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS58193.1 [Q11206-1]
CCDS58194.1 [Q11206-2]
CCDS8474.1 [Q11206-5]

Protein sequence database of the Protein Information Resource

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PIRi
A48715
A49879

NCBI Reference Sequences

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RefSeqi
NP_001241686.1, NM_001254757.1 [Q11206-1]
NP_001241687.1, NM_001254758.1 [Q11206-1]
NP_001241688.1, NM_001254759.1 [Q11206-2]
NP_001335328.1, NM_001348399.1 [Q11206-1]
NP_001335329.1, NM_001348400.1 [Q11206-5]
NP_006269.1, NM_006278.2 [Q11206-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000227495; ENSP00000227495; ENSG00000110080 [Q11206-5]
ENST00000356132; ENSP00000348451; ENSG00000110080 [Q11206-4]
ENST00000392669; ENSP00000376437; ENSG00000110080 [Q11206-1]
ENST00000444328; ENSP00000394354; ENSG00000110080 [Q11206-1]
ENST00000449406; ENSP00000399444; ENSG00000110080 [Q11206-3]
ENST00000526727; ENSP00000436047; ENSG00000110080 [Q11206-1]
ENST00000530591; ENSP00000433989; ENSG00000110080 [Q11206-5]
ENST00000532243; ENSP00000434349; ENSG00000110080 [Q11206-2]
ENST00000534083; ENSP00000433318; ENSG00000110080 [Q11206-1]
ENST00000534457; ENSP00000434668; ENSG00000110080 [Q11206-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6484

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6484

UCSC genome browser

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UCSCi
uc001qds.4, human [Q11206-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal IV

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23767 mRNA Translation: AAA16460.1
X74570 mRNA Translation: CAA52662.1
AF516603 mRNA Translation: AAM66432.1
AF516604 mRNA Translation: AAM66433.1
AY040826 mRNA Translation: AAK93790.1
AK291577 mRNA Translation: BAF84266.1
AP000806 Genomic DNA No translation available.
AP001318 Genomic DNA No translation available.
BC010645 mRNA Translation: AAH10645.1
AF035249 mRNA Translation: AAC14162.1
CCDSiCCDS58193.1 [Q11206-1]
CCDS58194.1 [Q11206-2]
CCDS8474.1 [Q11206-5]
PIRiA48715
A49879
RefSeqiNP_001241686.1, NM_001254757.1 [Q11206-1]
NP_001241687.1, NM_001254758.1 [Q11206-1]
NP_001241688.1, NM_001254759.1 [Q11206-2]
NP_001335328.1, NM_001348399.1 [Q11206-1]
NP_001335329.1, NM_001348400.1 [Q11206-5]
NP_006269.1, NM_006278.2 [Q11206-5]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112377, 24 interactors
IntActiQ11206, 13 interactors
STRINGi9606.ENSP00000436047

Chemistry databases

SwissLipidsiSLP:000001384

Protein family/group databases

CAZyiGT29, Glycosyltransferase Family 29

PTM databases

GlyGeniQ11206, 4 sites
iPTMnetiQ11206
PhosphoSitePlusiQ11206

Polymorphism and mutation databases

BioMutaiST3GAL4

Proteomic databases

jPOSTiQ11206
MassIVEiQ11206
MaxQBiQ11206
PaxDbiQ11206
PeptideAtlasiQ11206
PRIDEiQ11206
ProteomicsDBi58900 [Q11206-1]
58901 [Q11206-2]
58902 [Q11206-3]
58903 [Q11206-4]
58904 [Q11206-5]
72151

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33000, 156 antibodies

The DNASU plasmid repository

More...
DNASUi
6484

Genome annotation databases

EnsembliENST00000227495; ENSP00000227495; ENSG00000110080 [Q11206-5]
ENST00000356132; ENSP00000348451; ENSG00000110080 [Q11206-4]
ENST00000392669; ENSP00000376437; ENSG00000110080 [Q11206-1]
ENST00000444328; ENSP00000394354; ENSG00000110080 [Q11206-1]
ENST00000449406; ENSP00000399444; ENSG00000110080 [Q11206-3]
ENST00000526727; ENSP00000436047; ENSG00000110080 [Q11206-1]
ENST00000530591; ENSP00000433989; ENSG00000110080 [Q11206-5]
ENST00000532243; ENSP00000434349; ENSG00000110080 [Q11206-2]
ENST00000534083; ENSP00000433318; ENSG00000110080 [Q11206-1]
ENST00000534457; ENSP00000434668; ENSG00000110080 [Q11206-6]
GeneIDi6484
KEGGihsa:6484
UCSCiuc001qds.4, human [Q11206-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6484
DisGeNETi6484
EuPathDBiHostDB:ENSG00000110080.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ST3GAL4
HGNCiHGNC:10864, ST3GAL4
HPAiENSG00000110080, Tissue enhanced (placenta)
MIMi104240, gene
neXtProtiNX_Q11206
OpenTargetsiENSG00000110080
PharmGKBiPA35766

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2692, Eukaryota
GeneTreeiENSGT00940000158893
HOGENOMiCLU_032020_1_0_1
InParanoidiQ11206
KOiK03494
OMAiSIHYYEY
OrthoDBi891104at2759
PhylomeDBiQ11206
TreeFamiTF354325

Enzyme and pathway databases

UniPathwayiUPA00378
BioCyciMetaCyc:HS03285-MONOMER
BRENDAi2.4.99.4, 2681
2.4.99.6, 2681
PathwayCommonsiQ11206
ReactomeiR-HSA-1912420, Pre-NOTCH Processing in Golgi
R-HSA-2022854, Keratan sulfate biosynthesis
R-HSA-4085001, Sialic acid metabolism
R-HSA-9037629, Lewis blood group biosynthesis
R-HSA-975577, N-Glycan antennae elongation
R-HSA-977068, Termination of O-glycan biosynthesis
SIGNORiQ11206

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6484, 6 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ST3GAL4, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ST3GAL4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6484
PharosiQ11206, Tbio

Protein Ontology

More...
PROi
PR:Q11206
RNActiQ11206, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110080, Expressed in left adrenal gland and 220 other tissues
ExpressionAtlasiQ11206, baseline and differential
GenevisibleiQ11206, HS

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675, Glyco_trans_29
IPR038578, GT29-like_sf
IPR012163, Sialyl_trans
PfamiView protein in Pfam
PF00777, Glyco_transf_29, 1 hit
PIRSFiPIRSF005557, Sialyl_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIA4C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q11206
Secondary accession number(s): A8K6B2
, O60497, Q8N6A6, Q8NFG7, Q96QQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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