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Protein

Probable endochitinase

Gene

cht-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • chitin catabolic process Source: GO_Central
  • polysaccharide catabolic process Source: UniProtKB-KW
  • response to fungus Source: WormBase

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Enzyme and pathway databases

ReactomeiR-CEL-189085 Digestion of dietary carbohydrate
R-CEL-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiCBM14 Carbohydrate-Binding Module Family 14
GH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endochitinase (EC:3.2.1.14)
Gene namesi
Name:cht-1
ORF Names:C04F6.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC04F6.3 ; CE03923 ; WBGene00000503 ; cht-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000770491 – 617Probable endochitinaseAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi310N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi511 ↔ 524PROSITE-ProRule annotation
Disulfide bondi594 ↔ 607PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ11174
PaxDbiQ11174
PeptideAtlasiQ11174
PRIDEiQ11174

PTM databases

iPTMnetiQ11174

Expressioni

Gene expression databases

BgeeiWBGene00000503

Interactioni

Protein-protein interaction databases

STRINGi6239.C04F6.3.1

Structurei

3D structure databases

ProteinModelPortaliQ11174
SMRiQ11174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini478 – 534Chitin-binding type-2 1PROSITE-ProRule annotationAdd BLAST57
Domaini563 – 617Chitin-binding type-2 2PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi435 – 478Thr-richAdd BLAST44

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
HOGENOMiHOG000111109
InParanoidiQ11174
KOiK01183
OMAiVCYQGTW
OrthoDBiEOG091G014W
PhylomeDBiQ11174

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01607 CBM_14, 2 hits
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00494 ChtBD2, 2 hits
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
SSF54556 SSF54556, 1 hit
SSF57625 SSF57625, 2 hits
PROSITEiView protein in PROSITE
PS50940 CHIT_BIND_II, 2 hits
PS01095 CHITINASE_18, 1 hit

Sequencei

Sequence statusi: Complete.

Q11174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGKFLLVA SFILPIAYTW TGATIRNHPA DVVAARNKIT SRSVARSEPT
60 70 80 90 100
NSYIRPCYFT NWAQYRQGRA KFVPEDYTPG LCTHILFAFG WMNADYTVRA
110 120 130 140 150
YDPADLPNDW AGEGMYRRVN KLKVTDTQLK TLLSFGGWSF GTALFQGMAA
160 170 180 190 200
SSASRKVFID SAITFVRTWG FDGIDIDWEY PSGATDMANY VALVKELKAA
210 220 230 240 250
CESEAGSTGK DRLLVTAAVA AGPATIDAGY DIPNLAPNFD FILLMSYDFF
260 270 280 290 300
GAWASLVGFN SPLYATTELP AEWNGWNVDS SARYWNQKGM PKEKIIVGMP
310 320 330 340 350
TYGRGWTLNN ASAINPGTSG SPAKITQYVQ EAGVGAYFEF CEMLANGATR
360 370 380 390 400
YWDSQSQVPY LVQGNQWWSY DDEESFANKM AYVKREGYGG AFVWTLDFDD
410 420 430 440 450
FNAGCSNSNG QLYPLISVIA KELGGVIIPK KGGVTTAPTT VATTVTTGRP
460 470 480 490 500
PMTSAVTTTT AATTTTTRAA TTTTASNTNV CSGKSDGFYP NSNNCGLFVL
510 520 530 540 550
CLSSKSYSMS CPSGLQYSAS LKYCTTSTAS GCSVTTTRAP TTTTKSAPTV
560 570 580 590 600
TTTTRAPTTT TPAFKCTKDG FFGVPSDCLK FIRCVNGISY NFECPNGLSF
610
HADTMMCDRP DPSKCAK
Length:617
Mass (Da):66,857
Last modified:November 1, 1997 - v1
Checksum:iDDA1D2AAAC0E54DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138W → C in AAB81847 (PubMed:9662472).Curated1
Sequence conflicti163 – 165ITF → TTS in AAB81847 (PubMed:9662472).Curated3
Sequence conflicti176I → L in AAB81847 (PubMed:9662472).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080344 Genomic DNA Translation: CCD63028.1
AF026152 Genomic DNA Translation: AAB81847.1
PIRiT15408
T37249
RefSeqiNP_508588.1, NM_076187.4
UniGeneiCel.17326

Genome annotation databases

EnsemblMetazoaiC04F6.3; C04F6.3; WBGene00000503
GeneIDi180628
KEGGicel:CELE_C04F6.3
UCSCiC04F6.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCHIT_CAEEL
AccessioniPrimary (citable) accession number: Q11174
Secondary accession number(s): O17321
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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