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Protein

Alpha-(1,3)-fucosyltransferase 5

Gene

FUT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
  • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  • fucosyltransferase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS05379-MONOMER
BRENDAi2.4.1.152 2681
2.4.1.65 2681
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Chemistry databases

SwissLipidsiSLP:000001430

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 5 (EC:2.4.1.65)
Alternative name(s):
Fucosyltransferase 5
Fucosyltransferase V
Short name:
Fuc-TV
Short name:
FucT-V
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130383.7
HGNCiHGNC:4016 FUT5
MIMi136835 gene
neXtProtiNX_Q11128

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
Topological domaini35 – 374LumenalSequence analysisAdd BLAST340

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2527
PharmGKBiPA28432

Chemistry databases

ChEMBLiCHEMBL3146

Polymorphism and mutation databases

BioMutaiFUT5
DMDMi1730135

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211051 – 374Alpha-(1,3)-fucosyltransferase 5Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ11128
PaxDbiQ11128
PeptideAtlasiQ11128
PRIDEiQ11128
ProteomicsDBi58871

PTM databases

iPTMnetiQ11128
PhosphoSitePlusiQ11128

Expressioni

Tissue specificityi

Liver, colon and testis and trace amounts in T-cells and brain.

Gene expression databases

BgeeiENSG00000130383 Expressed in 8 organ(s), highest expression level in testis
CleanExiHS_FUT5
ExpressionAtlasiQ11128 baseline and differential
GenevisibleiQ11128 HS

Organism-specific databases

HPAiHPA046966

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252675

Chemistry databases

BindingDBiQ11128

Structurei

3D structure databases

ProteinModelPortaliQ11128
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiQ11128
KOiK07633
OrthoDBiEOG091G0846
PhylomeDBiQ11128

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q11128-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLGPAKPQ WLWRRCLAGL LFQLLVAVCF FSYLRVSRDD ATGSPRPGLM
60 70 80 90 100
AVEPVTGAPN GSRCQDSMAT PAHPTLLILL WTWPFNTPVA LPRCSEMVPG
110 120 130 140 150
AADCNITADS SVYPQADAVI VHHWDIMYNP SANLPPPTRP QGQRWIWFSM
160 170 180 190 200
ESPSNCRHLE ALDGYFNLTM SYRSDSDIFT PYGWLEPWSG QPAHPPLNLS
210 220 230 240 250
AKTELVAWAV SNWKPDSARV RYYQSLQAHL KVDVYGRSHK PLPKGTMMET
260 270 280 290 300
LSRYKFYLAF ENSLHPDYIT EKLWRNALEA WAVPVVLGPS RSNYERFLPP
310 320 330 340 350
DAFIHVDDFQ SPKDLARYLQ ELDKDHARYL SYFRWRETLR PRSFSWALAF
360 370
CKACWKLQQE SRYQTVRSIA AWFT
Length:374
Mass (Da):43,008
Last modified:October 1, 1996 - v1
Checksum:iB825281521B57939
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENC0K7ENC0_HUMAN
Alpha-(1,3)-fucosyltransferase 5
FUT5
374Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022122187P → L. Corresponds to variant dbSNP:rs778970Ensembl.1
Natural variantiVAR_055845338T → M. Corresponds to variant dbSNP:rs4807054Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81485 Genomic DNA Translation: AAA98117.1
U27329 mRNA Translation: AAC50188.1
U27330 mRNA Translation: AAC50189.1
AK291087 mRNA Translation: BAF83776.1
AC024592 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69134.1
BC140905 mRNA Translation: AAI40906.1
CCDSiCCDS12154.1
PIRiA42270
RefSeqiNP_002025.2, NM_002034.2
UniGeneiHs.631843

Genome annotation databases

EnsembliENST00000252675; ENSP00000252675; ENSG00000130383
GeneIDi2527
KEGGihsa:2527
UCSCiuc060sei.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81485 Genomic DNA Translation: AAA98117.1
U27329 mRNA Translation: AAC50188.1
U27330 mRNA Translation: AAC50189.1
AK291087 mRNA Translation: BAF83776.1
AC024592 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69134.1
BC140905 mRNA Translation: AAI40906.1
CCDSiCCDS12154.1
PIRiA42270
RefSeqiNP_002025.2, NM_002034.2
UniGeneiHs.631843

3D structure databases

ProteinModelPortaliQ11128
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000252675

Chemistry databases

BindingDBiQ11128
ChEMBLiCHEMBL3146
SwissLipidsiSLP:000001430

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

PTM databases

iPTMnetiQ11128
PhosphoSitePlusiQ11128

Polymorphism and mutation databases

BioMutaiFUT5
DMDMi1730135

Proteomic databases

MaxQBiQ11128
PaxDbiQ11128
PeptideAtlasiQ11128
PRIDEiQ11128
ProteomicsDBi58871

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252675; ENSP00000252675; ENSG00000130383
GeneIDi2527
KEGGihsa:2527
UCSCiuc060sei.1 human

Organism-specific databases

CTDi2527
DisGeNETi2527
EuPathDBiHostDB:ENSG00000130383.7
GeneCardsiFUT5
H-InvDBiHIX0213024
HGNCiHGNC:4016 FUT5
HPAiHPA046966
MIMi136835 gene
neXtProtiNX_Q11128
PharmGKBiPA28432
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiQ11128
KOiK07633
OrthoDBiEOG091G0846
PhylomeDBiQ11128

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS05379-MONOMER
BRENDAi2.4.1.152 2681
2.4.1.65 2681

Miscellaneous databases

ChiTaRSiFUT5 human
GeneWikiiFUT5
GenomeRNAii2527
PROiPR:Q11128
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130383 Expressed in 8 organ(s), highest expression level in testis
CleanExiHS_FUT5
ExpressionAtlasiQ11128 baseline and differential
GenevisibleiQ11128 HS

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFUT5_HUMAN
AccessioniPrimary (citable) accession number: Q11128
Secondary accession number(s): A8K4X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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