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Entry version 116 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

UV-damage endonuclease

Gene

uve1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway. Functions also in oxidative damage repair in vivo. Provides back-up AP endonuclease activity to apn2 together with apn1.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA excision, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UV-damage endonuclease (EC:3.-.-.-)
Short name:
UVDE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uve1
Synonyms:uvde
ORF Names:SPBC19C7.09c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

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PomBasei
SPBC19C7.09c, uve1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC19C7.09c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002150291 – 599UV-damage endonucleaseAdd BLAST599

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10988

PRoteomics IDEntifications database

More...
PRIDEi
Q10988

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q10988

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q10988

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By UV light.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
276874, 26 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC19C7.09c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q10988

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni89 – 224DisorderedSequence analysisAdd BLAST136
Regioni561 – 599DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi145 – 159Polar residuesSequence analysisAdd BLAST15
Compositional biasi160 – 191Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi205 – 224Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi580 – 599Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the uve1/UvsE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QTMI, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017168_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10988

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRETWTR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10988

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004601, UvdE
IPR036237, Xyl_isomerase-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR31290, PTHR31290, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03851, UvdE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51658, SSF51658, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00629, uvde, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10988-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLLKRNIQ ISKRIVFTIL KQKAFKGNHP CVPSVCTITY SRFHCLPDTL
60 70 80 90 100
KSLLPMSSKT TLSMLPQVNI GANSFSAETP VDLKKENETE LANISGPHKK
110 120 130 140 150
STSTSTRKRA RSSKKKATDS VSDKIDESVA SYDSSTHLRR SSRSKKPVNY
160 170 180 190 200
NSSSESESEE QISKATKKVK QKEEEEYVEE VDEKSLKNES SSDEFEPVVP
210 220 230 240 250
EQLETPISKR RRSRSSAKNL EKESTMNLDD HAPREMFDCL DKPIPWRGRL
260 270 280 290 300
GYACLNTILR SMKERVFCSR TCRITTIQRD GLESVKQLGT QNVLDLIKLV
310 320 330 340 350
EWNHNFGIHF MRVSSDLFPF ASHAKYGYTL EFAQSHLEEV GKLANKYNHR
360 370 380 390 400
LTMHPGQYTQ IASPREVVVD SAIRDLAYHD EILSRMKLNE QLNKDAVLII
410 420 430 440 450
HLGGTFEGKK ETLDRFRKNY QRLSDSVKAR LVLENDDVSW SVQDLLPLCQ
460 470 480 490 500
ELNIPLVLDW HHHNIVPGTL REGSLDLMPL IPTIRETWTR KGITQKQHYS
510 520 530 540 550
ESADPTAISG MKRRAHSDRV FDFPPCDPTM DLMIEAKEKE QAVFELCRRY
560 570 580 590
ELQNPPCPLE IMGPEYDQTR DGYYPPGAEK RLTARKRRSR KEEVEEDEK
Length:599
Mass (Da):68,816
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC09ED7219D5895BE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78571 mRNA Translation: BAA11415.1
U78487 Genomic DNA Translation: AAC49664.1
CU329671 Genomic DNA Translation: CAA19577.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S71134

NCBI Reference Sequences

More...
RefSeqi
NP_596165.1, NM_001022085.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC19C7.09c.1; SPBC19C7.09c.1:pep; SPBC19C7.09c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC19C7.09c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78571 mRNA Translation: BAA11415.1
U78487 Genomic DNA Translation: AAC49664.1
CU329671 Genomic DNA Translation: CAA19577.1
PIRiS71134
RefSeqiNP_596165.1, NM_001022085.2

3D structure databases

SMRiQ10988
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276874, 26 interactors
STRINGi4896.SPBC19C7.09c.1

PTM databases

iPTMnetiQ10988
SwissPalmiQ10988

Proteomic databases

PaxDbiQ10988
PRIDEiQ10988

Genome annotation databases

EnsemblFungiiSPBC19C7.09c.1; SPBC19C7.09c.1:pep; SPBC19C7.09c
GeneIDi2540345
KEGGispo:SPBC19C7.09c

Organism-specific databases

PomBaseiSPBC19C7.09c, uve1
VEuPathDBiFungiDB:SPBC19C7.09c

Phylogenomic databases

eggNOGiENOG502QTMI, Eukaryota
HOGENOMiCLU_017168_3_0_1
InParanoidiQ10988
OMAiIRETWTR
PhylomeDBiQ10988

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10988

Family and domain databases

InterProiView protein in InterPro
IPR004601, UvdE
IPR036237, Xyl_isomerase-like_sf
PANTHERiPTHR31290, PTHR31290, 1 hit
PfamiView protein in Pfam
PF03851, UvdE, 1 hit
SUPFAMiSSF51658, SSF51658, 1 hit
TIGRFAMsiTIGR00629, uvde, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUVE1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10988
Secondary accession number(s): P87339
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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