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Entry version 179 (11 Dec 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Galactoside 2-alpha-L-fucosyltransferase 2

Gene

FUT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).5 Publications

Miscellaneous

There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=11.5 mM for phenyl-beta-D-galactoside1 Publication
  2. KM=3.6 mM for lacto-N-biose1 Publication
  3. KM=3.8 mM for N-acetyllactosamine1 Publication
  4. KM=197 µM for GDP-fucose1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • fucosyltransferase activity Source: ProtInc
    • galactoside 2-alpha-L-fucosyltransferase activity Source: GO_Central

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionBlood group antigen, Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS11104-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.1.69 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-9033807 ABO blood group biosynthesis
    R-HSA-9037629 Lewis blood group biosynthesis

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q10981

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00378

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT11 Glycosyltransferase Family 11

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2 (EC:2.4.1.3441 Publication, EC:2.4.1.691 Publication)
    Alternative name(s):
    Alpha(1,2)FT 2
    Fucosyltransferase 2
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    SE2
    Secretor blood group alpha-2-fucosyltransferase
    Secretor factor
    Short name:
    Se
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:FUT2
    Synonyms:SEC2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000176920.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:4013 FUT2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    182100 gene+phenotype

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q10981

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST14
    Topological domaini29 – 343LumenalSequence analysisAdd BLAST315

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2524

    MalaCards human disease database

    More...
    MalaCardsi
    FUT2
    MIMi182100 gene+phenotype
    612542 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000176920

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA28429

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q10981 Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4105777

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    FUT2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    1730125

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000121401 – 343Galactoside 2-alpha-L-fucosyltransferase 2Add BLAST343

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q10981

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q10981

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q10981

    PeptideAtlas

    More...
    PeptideAtlasi
    Q10981

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q10981

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q10981

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q10981

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Small intestine, colon and lung.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000176920 Expressed in 137 organ(s), highest expression level in minor salivary gland

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q10981 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q10981 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA014402

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    108800, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    Q10981, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000387498

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q10981 protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 11 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IFKR Eukaryota
    ENOG4111HG3 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000001450

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000261621

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q10981

    KEGG Orthology (KO)

    More...
    KOi
    K00718

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    AFLPEWT

    Database of Orthologous Groups

    More...
    OrthoDBi
    1006406at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q10981

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315810

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002516 Glyco_trans_11

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11927 PTHR11927, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01531 Glyco_transf_11, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q10981-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS
    60 70 80 90 100
    TSKALGPSQL RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH
    110 120 130 140 150
    STLAPIFRIT LPVLHSATAS RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY
    160 170 180 190 200
    PCSWTFYHHL RQEILQEFTL HDHVREEAQK FLRGLQVNGS RPGTFVGVHV
    210 220 230 240 250
    RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV VTSNGMAWCR
    260 270 280 290 300
    ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG
    310 320 330 340
    GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH
    Length:343
    Mass (Da):39,017
    Last modified:October 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12066D9CF175E13A
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA11638 differs from that shown. Reason: Erroneous initiation.Curated

    <p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Three alleles have been identified in the Japanese population: Se1, Se2, and Sej.1 Publication
    Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1 (B12QTL1) [MIMi:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency.1 Publication
    Genetic variation in FUT2 results in the non-secretor phenotype which gives rise to non-functional FUT2, resulting in a lack of the H type-1 oligosaccharide ligand in secretions, and this prevents Norwalk virus binding contributing to resistance to Norwalk virus infection.1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00342225I → V Polymorphism found in Xhosa population. 2 PublicationsCorresponds to variant dbSNP:rs1800021Ensembl.1
    Natural variantiVAR_003423138R → C Polymorphism found in Xhosa population. 2 PublicationsCorresponds to variant dbSNP:rs1800022Ensembl.1
    Natural variantiVAR_003424140I → F in allele Sej; non-secretor phenotype. 3 PublicationsCorresponds to variant dbSNP:rs1047781EnsemblClinVar.1
    Natural variantiVAR_003425172D → N Polymorphism found in Xhosa population. 2 PublicationsCorresponds to variant dbSNP:rs1800025Ensembl.1
    Natural variantiVAR_022187258G → S1 PublicationCorresponds to variant dbSNP:rs602662Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U17894 Genomic DNA Translation: AAC24453.1
    D87942 mRNA Translation: BAA21684.1
    AY937240 Genomic DNA Translation: AAX14047.1
    BC121066 mRNA No translation available.
    D89327 Genomic DNA Translation: BAA13944.1
    D82933 Genomic DNA Translation: BAA11638.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS33069.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A56098

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000502.4, NM_000511.5
    NP_001091107.1, NM_001097638.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000391876; ENSP00000375748; ENSG00000176920
    ENST00000425340; ENSP00000387498; ENSG00000176920
    ENST00000522966; ENSP00000430227; ENSG00000176920

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2524

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2524

    UCSC genome browser

    More...
    UCSCi
    uc010emc.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    SeattleSNPs
    Functional Glycomics Gateway - GTase

    Fucosyltransferase 2

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U17894 Genomic DNA Translation: AAC24453.1
    D87942 mRNA Translation: BAA21684.1
    AY937240 Genomic DNA Translation: AAX14047.1
    BC121066 mRNA No translation available.
    D89327 Genomic DNA Translation: BAA13944.1
    D82933 Genomic DNA Translation: BAA11638.1 Different initiation.
    CCDSiCCDS33069.1
    PIRiA56098
    RefSeqiNP_000502.4, NM_000511.5
    NP_001091107.1, NM_001097638.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi108800, 1 interactor
    IntActiQ10981, 1 interactor
    STRINGi9606.ENSP00000387498

    Chemistry databases

    ChEMBLiCHEMBL4105777

    Protein family/group databases

    CAZyiGT11 Glycosyltransferase Family 11

    PTM databases

    iPTMnetiQ10981
    PhosphoSitePlusiQ10981

    Polymorphism and mutation databases

    BioMutaiFUT2
    DMDMi1730125

    Proteomic databases

    jPOSTiQ10981
    MassIVEiQ10981
    PaxDbiQ10981
    PeptideAtlasiQ10981
    PRIDEiQ10981

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    2524

    Genome annotation databases

    EnsembliENST00000391876; ENSP00000375748; ENSG00000176920
    ENST00000425340; ENSP00000387498; ENSG00000176920
    ENST00000522966; ENSP00000430227; ENSG00000176920
    GeneIDi2524
    KEGGihsa:2524
    UCSCiuc010emc.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2524
    DisGeNETi2524
    EuPathDBiHostDB:ENSG00000176920.11

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    FUT2
    HGNCiHGNC:4013 FUT2
    HPAiHPA014402
    MalaCardsiFUT2
    MIMi182100 gene+phenotype
    612542 phenotype
    neXtProtiNX_Q10981
    OpenTargetsiENSG00000176920
    PharmGKBiPA28429

    GenAtlas: human gene database

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    GenAtlasi
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    Phylogenomic databases

    eggNOGiENOG410IFKR Eukaryota
    ENOG4111HG3 LUCA
    GeneTreeiENSGT00390000001450
    HOGENOMiHOG000261621
    InParanoidiQ10981
    KOiK00718
    OMAiAFLPEWT
    OrthoDBi1006406at2759
    PhylomeDBiQ10981
    TreeFamiTF315810

    Enzyme and pathway databases

    UniPathwayiUPA00378
    BioCyciMetaCyc:HS11104-MONOMER
    BRENDAi2.4.1.69 2681
    ReactomeiR-HSA-9033807 ABO blood group biosynthesis
    R-HSA-9037629 Lewis blood group biosynthesis
    SIGNORiQ10981

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    FUT2 human

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    FUT2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    2524
    PharosiQ10981 Tbio

    Protein Ontology

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    PROi
    PR:Q10981
    RNActiQ10981 protein

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
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    Gene expression databases

    BgeeiENSG00000176920 Expressed in 137 organ(s), highest expression level in minor salivary gland
    ExpressionAtlasiQ10981 baseline and differential
    GenevisibleiQ10981 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002516 Glyco_trans_11
    PANTHERiPTHR11927 PTHR11927, 1 hit
    PfamiView protein in Pfam
    PF01531 Glyco_transf_11, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUT2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10981
    Secondary accession number(s): Q0VAG5, Q14338, Q5D0G2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: December 11, 2019
    This is version 179 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    7. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
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