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Protein

Galactoside 2-alpha-L-fucosyltransferase 1

Gene

Fut1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.By similarity

Miscellaneous

There are two genes (Fut1 and Fut2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.69 5301
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT11 Glycosyltransferase Family 11

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1 (EC:2.4.1.344By similarity)
Alternative name(s):
Alpha 1,2-fucosyltransferase A
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
Gene namesi
Name:Fut1
Synonyms:Fta
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2638 Fut1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini30 – 376LumenalSequence analysisAdd BLAST347

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491021 – 376Galactoside 2-alpha-L-fucosyltransferase 1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ10980
PRIDEiQ10980

PTM databases

iPTMnetiQ10980
PhosphoSitePlusiQ10980

Expressioni

Gene expression databases

BgeeiENSRNOG00000020995 Expressed in 9 organ(s), highest expression level in colon
GenevisibleiQ10980 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028494

Structurei

3D structure databases

SMRiQ10980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKR Eukaryota
ENOG4111HG3 LUCA
GeneTreeiENSGT00390000001450
HOGENOMiHOG000261621
HOVERGENiHBG004338
InParanoidiQ10980
KOiK00718
OMAiFLHIHQD
OrthoDBiEOG091G0X2P
PhylomeDBiQ10980
TreeFamiTF315810

Family and domain databases

InterProiView protein in InterPro
IPR002516 Glyco_trans_11
PANTHERiPTHR11927 PTHR11927, 1 hit
PfamiView protein in Pfam
PF01531 Glyco_transf_11, 1 hit

Sequencei

Sequence statusi: Complete.

Q10980-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTPSRKQLC LAFLSVCVLS AGSFFFHLNG GNFFQNALTF SVLCPDYHLL
60 70 80 90 100
KSPVAMVCLP YPSNASSGSP SCPEQSLLSG TWTITPGGRF GNQMGQYATL
110 120 130 140 150
LALAQLNGRR AFIQPEMHTT LAPVFRISLP VLDPEVDSLT PWQHLVLHDW
160 170 180 190 200
MSEEYSHLED PFLKLSGFPC SWTFFHHLRE QIRREFTLHD HLREDAQRLL
210 220 230 240 250
SGLRIGPAGI RPRTYVGVHV RRGDYLEVMP NRWKGVVGDR AYLQKAMDWF
260 270 280 290 300
RARHKDPIFV VTSNGMRWCL ENIDTSHGDV VFAGNGQEGT PGKDFALLTQ
310 320 330 340 350
CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF RPKAAFLPEW
360 370
VGINADLSPL QAQFDPWETD SLFRLA
Length:376
Mass (Da):42,417
Last modified:July 15, 1999 - v2
Checksum:iC350C737C758B7F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015637 Genomic DNA Translation: BAA31130.1
AB006137 mRNA Translation: BAA21741.1
AF131237 Genomic DNA Translation: AAD24468.1
L26009 mRNA Translation: AAB41514.1
PIRiS51582
RefSeqiNP_112515.1, NM_031236.1
XP_008757642.1, XM_008759420.2
UniGeneiRn.11382

Genome annotation databases

EnsembliENSRNOT00000028494; ENSRNOP00000028494; ENSRNOG00000020995
GeneIDi81919
KEGGirno:81919
UCSCiRGD:2638 rat

Similar proteinsi

Entry informationi

Entry nameiFUT1_RAT
AccessioniPrimary (citable) accession number: Q10980
Secondary accession number(s): Q549F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: September 12, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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