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Entry version 138 (08 May 2019)
Sequence version 2 (01 Jun 2001)
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Protein

Armadillo repeat-containing protein wrm-1

Gene

wrm-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1-dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning and can activation transcription in yeast. Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (PubMed:17476329).10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5218920 VEGFR2 mediated vascular permeability
R-CEL-6798695 Neutrophil degranulation
R-CEL-6809371 Formation of the cornified envelope

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q10953

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Armadillo repeat-containing protein wrm-1
Alternative name(s):
Worm armadillo protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wrm-1Imported
ORF Names:B0336.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
B0336.1 ; CE26743 ; WBGene00006943 ; wrm-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit premature cell cleavage during embryogenesis, symmetrical cell division during gonadogenesis and undifferentiated intestines. Embryos show a defect in centrosome positioning that delays ABar spindle alignment and appear to lack endoderm.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003427011 – 796Armadillo repeat-containing protein wrm-1Add BLAST796

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q10953

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10953

PeptideAtlas

More...
PeptideAtlasi
Q10953

PRoteomics IDEntifications database

More...
PRIDEi
Q10953

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing cells of the embryo including hypodermal cells, neuroblasts, and mesodermal cells (PubMed:15572126). Expressed in seam cells in hermaphrodites at the L2 stage of larval development (PubMed:25569233).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006943 Expressed in 5 organ(s), highest expression level in adult organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q10953 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (independently of ARM repeat) with nhr-25. Interacts (via N-terminus) with lit-1; activates lit-1 kinase activity and the wrm-1/lit-1 dimer phosphorylates pop-1 which promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
41028, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1130 Beta-catenin-lit-1 complex

Protein interaction database and analysis system

More...
IntActi
Q10953, 22 interactors

Molecular INTeraction database

More...
MINTi
Q10953

STRING: functional protein association networks

More...
STRINGi
6239.B0336.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10953

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati462 – 504ARMSequence analysisAdd BLAST43

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410K88M Eukaryota
ENOG4110KM8 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154864

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10953

KEGG Orthology (KO)

More...
KOi
K02105

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIYENCL

Database of Orthologous Groups

More...
OrthoDBi
642513at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q10953-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVDCAETFS QPCTPLNFNP MTPSTSRVST PVRPSSTMSA RQYSGSPFKA
60 70 80 90 100
QPQNMEPSNS RVQELREAAV GKRSYTNAWM QGTYAPPQMA GQQQRFSRPP
110 120 130 140 150
SVIGSTMSHM TNMSEMTAYS YGGLSMLSVN TEMGEFNNFV NQAPYQRALT
160 170 180 190 200
RVSQVSENQD PTNRQYPMTA PEIIENLEST ELINQAAAIR ALEPIVKAGG
210 220 230 240 250
MLQTWGPKGA EPIIRALFQV LIPRPVENEN VIRKAFEILH HSILLSNKEI
260 270 280 290 300
RRIDRMFFRL NAALMDPNGP PVFNVPKPYS IYEIVMTRAI QLDTKFESSA
310 320 330 340 350
MVLLVHLCCK PHFMKIFFGE DETQQSPAHR RLHKIVIEFA IGNLRRPETK
360 370 380 390 400
SKNKGLCVSI IKNLSNKNAT IKDMSERLGV VSLFHQIMQN EVIHEDLLWS
410 420 430 440 450
TMQALTVFCG DVKNGTHFVQ MGGAQVLCGL LSHGSTRLLH ELLKCLRRVS
460 470 480 490 500
DLPAIQEQDM KESIHCIVQL IGCSDVTIVE LATGTLRNIG LHNKMNKAFM
510 520 530 540 550
VQDGVTSHAI AVLRTSEQFT YQPHANIDLY RKQILSIYEN CLSVLNNVTS
560 570 580 590 600
MAPQDIKESA VSACRMISEN ADSAYVLLHY FNVGNRKCRK LAVTVMKRVI
610 620 630 640 650
ETVPAFADPF VDLLGTTNEP LPILLLQRAF QSLDEWRKTS VEMMNCDGRS
660 670 680 690 700
AEQRRELDDR RKDHEDIVKR SVGLLTNLCS QANPRFFHSL KLVLTNGTLN
710 720 730 740 750
PFQWLTHEMS DGILQEWLAF ILSICSRDES LQTFMMYRFL EQAKMTEAFF
760 770 780 790
AELKARRQNS NIQTMLSKII DLGRHQQRIV SQQHQQHQMQ HHRQLM
Length:796
Mass (Da):90,349
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB517C7A804A7DEA8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3AUT2A0A0K3AUT2_CAEEL
Armadillo repeat-containing protein...
wrm-1 B0336.1, CELE_B0336.1
742Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF013951 mRNA Translation: AAC47748.1
FO080138 Genomic DNA Translation: CCD61515.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T03746

NCBI Reference Sequences

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RefSeqi
NP_498236.1, NM_065835.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0336.1a.1; B0336.1a.1; WBGene00006943
B0336.1a.2; B0336.1a.2; WBGene00006943

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175802

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_B0336.1

UCSC genome browser

More...
UCSCi
B0336.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013951 mRNA Translation: AAC47748.1
FO080138 Genomic DNA Translation: CCD61515.1
PIRiT03746
RefSeqiNP_498236.1, NM_065835.6

3D structure databases

SMRiQ10953
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41028, 4 interactors
ComplexPortaliCPX-1130 Beta-catenin-lit-1 complex
IntActiQ10953, 22 interactors
MINTiQ10953
STRINGi6239.B0336.1

Proteomic databases

EPDiQ10953
PaxDbiQ10953
PeptideAtlasiQ10953
PRIDEiQ10953

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0336.1a.1; B0336.1a.1; WBGene00006943
B0336.1a.2; B0336.1a.2; WBGene00006943
GeneIDi175802
KEGGicel:CELE_B0336.1
UCSCiB0336.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175802
WormBaseiB0336.1 ; CE26743 ; WBGene00006943 ; wrm-1

Phylogenomic databases

eggNOGiENOG410K88M Eukaryota
ENOG4110KM8 LUCA
HOGENOMiHOG000154864
InParanoidiQ10953
KOiK02105
OMAiSIYENCL
OrthoDBi642513at2759

Enzyme and pathway databases

ReactomeiR-CEL-5218920 VEGFR2 mediated vascular permeability
R-CEL-6798695 Neutrophil degranulation
R-CEL-6809371 Formation of the cornified envelope
SignaLinkiQ10953

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10953

Gene expression databases

BgeeiWBGene00006943 Expressed in 5 organ(s), highest expression level in adult organism
ExpressionAtlasiQ10953 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
SMARTiView protein in SMART
SM00185 ARM, 3 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWRM1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10953
Secondary accession number(s): O16145
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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